Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men

Pischon, Tobias

doi:10.1001/jama.291.14.1730

Cited by 1,535 publications

(589 citation statements)

References 62 publications

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“…In humans, plasma adiponectin levels appear to be inversely related to insulin resistance and the severity of coronary artery disease (Cesari et al 2006). Interestingly, increased plasma adiponectin correlates with a reduced risk of MI in men (Pischon et al 2004) and a lower risk of coronary heart disease in diabetics (Schulze et al 2005). Oddly, adiponectin levels appear to decrease post-MI (Kojima et al 2003).…”

Section: Adiponectinmentioning

confidence: 99%

Role of adipokines in cardiovascular disease

Mattu¹,

Randeva²

2012

Journal of Endocrinology

240

196

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The discovery of leptin in 1994 sparked dramatic new interest in the study of white adipose tissue. It is now recognised to be a metabolically active endocrine organ, producing important chemical messengers -adipokines and cytokines (adipocytokines). The search for new adipocytokines or adipokines gained added fervour with the prospect of the reconciliation between cardiovascular diseases (CVDs), obesity and metabolic syndrome. The role these new chemical messengers play in inflammation, satiety, metabolism and cardiac function has paved the way for new research and theories examining the effects they have on (in this case) CVD. Adipokines are involved in a 'good-bad', yin-yang homoeostatic balance whereby there are substantial benefits: cardioprotection, promoting endothelial function, angiogenesis and reducing hypertension, atherosclerosis and inflammation. The flip side may show contrasting, detrimental effects in aggravating these cardiac parameters.

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Section: Adiponectinmentioning

confidence: 99%

Role of adipokines in cardiovascular disease

Mattu¹,

Randeva²

2012

Journal of Endocrinology

240

196

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show abstract

“…The beneficial effects of the MedDiet on health have basically been attributed to its high content of antioxidants, dietary fiber [45], MUFA and PUFA [46] and low glycemic load and glycemic index [47]. In particular, antioxidants and polyphenols have been shown to exert a protective role against ischemic CVD mainly due to their antiinflammatory properties [48].…”

Section: Inflammation and Dietary Patternsmentioning

confidence: 99%

Dietary Patterns, Foods, Nutrients and Chronic Inflammatory Disorders

Casas¹,

Estruch²

2016

Immunome Res

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The World Health Organization (WHO) recognizes that diet plays an important role in the prevention of several non-infectious diseases. Unhealthy diets that include high intake of red and processed meat, sweets and desserts, potatoes, French fries, and refined grains) is associated with high plasma inflammatory biomarkers and a greater risk of cardiovascular disease (CVD), type 2 diabetes (T2D), cancer and other chronic diseases. On the other hand, prudent dietary patterns such as Mediterranean diet as well as intake of fruit, vegetables, extra virgin olive oil, walnuts, legumes, whole grains, fish, cocoa, coffee, tea and wine is associated with a reduced plasma inflammatory biomarkers and a lower risk of CVD, T2D and other chronic diseases. In respect to nutrients, excessive intake of carbohydrates, saturated fat, trans-fatty acids, and omega-6 polyunsaturated fatty acids (PUFA) may activate the innate immune system, leading to an excessive production of pro inflammatory cytokines associated with a reduced synthesis of anti-inflammatory cytokines. On the other hand, omega-3 PUFA, vitamin E and polyphenols could counter the effects of several inflammatory markers, decreasing, for example, the secretion of circulating and cellular factors involved in the atherosclerotic process.This review explains how healthy dietary patterns, foods and nutrients can reduce chronic inflammatory processes related to CVD, T2D, obesity or cancer and therefore be a good tool to prevent the development of these disorders.

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“…Adiponectin, the most abundant protein secreted by the adipose tissue (Arita et al 1999) and circulating in human plasma as multimeric forms (Liu & Liu 2012), has been associated with endothelial improvement and vascular protection (Beltowski et al 2008, Zhu et al 2008 through the activation of an endothelial isoform of nitric oxide (eNOS)-related signaling, with antiinflammatory (Ouchi & Walsh 2007) and antiatherogenic properties (Barseghian et al 2011). It is also of interest that numerous epidemiological studies have correlated decreased adiponectin levels with an increased risk of cardiovascular disease in obesity and diabetes (Kumada et al 2003, Pischon et al 2004, Frystyk et al 2007) and with coronary artery disease (Hara et al 2007). As such, adiponectin deficiency has been reported to be predictive of future adverse cardiac events (Kojima et al 2006) and has been associated with increased oxidative stress and inferior recovery in cardiac function (Shibata et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Effect of monomeric adiponectin on cardiac function and perfusion in anesthetized pig

Grossini¹,

Prodam²,

Walker³

et al. 2014

Journal of Endocrinology

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Adiponectin, the most abundant adipokine released by adipose tissue, appears to play an important role in the regulation of vascular endothelial and cardiac function. To date, however, the physiological effects of human monomeric adiponectin on the coronary vasculature and myocardial systo-diastolic function, as well as on parasympathetic/sympathetic involvement and nitric oxide (NO) release, have not yet been investigated. Thus, we planned to determine the primary in vivo effects of human monomeric adiponectin on coronary blood flow and cardiac contractility/relaxation and the related role of autonomic nervous system, adiponectin receptors, and NO. In 30 anesthetized pigs, human monomeric adiponectin was infused into the left anterior descending coronary artery at constant heart rate and arterial blood pressure, and the effects on coronary blood flow, left ventricular systo-diastolic function, myocardial oxygen metabolism, and NO release were examined. The mechanisms of the observed hemodynamic responses were also analyzed by repeating the highest dose of human monomeric adiponectin infusion after autonomic nervous system and NO blockade, and after specific adiponectin 1 receptor antagonist administration. Intracoronary human monomeric adiponectin caused dose-related increases of coronary blood flow and cardiac function. Those effects were accompanied by increased coronary NO release and coronary adiponectin levels. Moreover, the vascular effects of the peptide were prevented by blockade of b 2 -adrenoceptors and NO synthase, whereas all effects of human monomeric adiponectin were prevented by adiponectin 1 receptor inhibitor. In conclusion, human monomeric adiponectin primarily increased coronary blood flow and cardiac systo-diastolic function through the involvement of specific receptors, b 2 -adrenoceptors, and NO release.

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Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men

Cited by 1,535 publications

References 62 publications

Role of adipokines in cardiovascular disease

Role of adipokines in cardiovascular disease

Dietary Patterns, Foods, Nutrients and Chronic Inflammatory Disorders

Effect of monomeric adiponectin on cardiac function and perfusion in anesthetized pig

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