2014
DOI: 10.1016/j.numecd.2013.04.015
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Plasma adiponectin in heart failure with and without cachexia: Catabolic signal linking catabolism, symptomatic status, and prognosis

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Cited by 58 publications
(56 citation statements)
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“…Generally, in contrast to the effects of leptin, the best characterized effects of adiponectin in humans include enhancement of insulin sensitivity, anti‐inflammatory properties, and inhibition of atherosclerosis . In particular, a stepwise increase of adiponectin with increasing HF severity has been described in humans, and recent studies also demonstrated an association between an increased serum adiponectin concentration and increased risk of mortality in HF patients . However, the mechanisms underlying the increase in serum adiponectin concentration in severe HF in humans remain undetermined.…”
Section: Discussionmentioning
confidence: 99%
“…Generally, in contrast to the effects of leptin, the best characterized effects of adiponectin in humans include enhancement of insulin sensitivity, anti‐inflammatory properties, and inhibition of atherosclerosis . In particular, a stepwise increase of adiponectin with increasing HF severity has been described in humans, and recent studies also demonstrated an association between an increased serum adiponectin concentration and increased risk of mortality in HF patients . However, the mechanisms underlying the increase in serum adiponectin concentration in severe HF in humans remain undetermined.…”
Section: Discussionmentioning
confidence: 99%
“…In this regard, Liao and his colleagues reported energetic defects in a mice model of transverse aortic constriction in relation to adiponectin deficiency. More recently, increased circulating adiponectin concentrations were associated with metabolic impairments and a hyper‐catabolic state in patients with HFrEF …”
Section: Skeletal Muscle Wasting: Is Adiponectin the Real Culprit?mentioning
confidence: 99%
“…In addition to the well‐described skeletal muscle energetic impairments, the majority of CHF patients develop muscle wasting . Muscle wasting is recognized as a critical component of cachexia contributing to muscle weakness and fatigue .…”
Section: Skeletal Muscle Wasting: Is Adiponectin the Real Culprit?mentioning
confidence: 99%
“…In studies, higher adiponectin levels were associated with greater radiographic progression in RA 13,14 , suggesting that this adipokine is associated with an aggressive disease phenotype. High adiponectin levels have been considered a biomarker of a catabolic state or cachectic state, such as that seen in starvation 15,16 . Therefore, high levels of adiponectin might be associated with poor prognosis in RA by identifying subjects with a severe phenotype also associated with a catabolic state, muscle wasting, and cachexia.…”
mentioning
confidence: 99%