Plasma adiponectin in heart failure with and without cachexia: Catabolic signal linking catabolism, symptomatic status, and prognosis

Szabó, Tibor; Scherbakov, Nadja; Sandek, Anja; Kung, Thomas; Haehling, S. von; Lainščak, Mitja; Jankowska, Ewa A.; Rudovich, Natalia; Anker, Stefan D.; Frystyk, Jan; Flyvbjerg, Allan; Pfeiffer, Andreas F. H.; Doehner, Wolfram

doi:10.1016/j.numecd.2013.04.015

Cited by 58 publications

(56 citation statements)

References 24 publications

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“…Generally, in contrast to the effects of leptin, the best characterized effects of adiponectin in humans include enhancement of insulin sensitivity, anti‐inflammatory properties, and inhibition of atherosclerosis . In particular, a stepwise increase of adiponectin with increasing HF severity has been described in humans, and recent studies also demonstrated an association between an increased serum adiponectin concentration and increased risk of mortality in HF patients . However, the mechanisms underlying the increase in serum adiponectin concentration in severe HF in humans remain undetermined.…”

Section: Discussionmentioning

confidence: 99%

Serum Concentrations of Leptin and Adiponectin in Dogs with Myxomatous Mitral Valve Disease

Kim

Kang

Jeung

et al. 2016

Veterinary Internal Medicne

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BackgroundThe concentrations of circulating adipokines in dogs with myxomatous mitral valve disease (MMVD) have not been investigated in detail.ObjectivesTo determine whether serum concentrations of adipokines differ between healthy dogs and dogs with MMVD and whether circulating concentrations depend on the severity of heart failure resulting from MMVD.AnimalsIn the preliminary study, 30 healthy dogs and 17 client‐owned dogs with MMVD, and in the subsequent study, 30 healthy dogs and 46 client‐owned dogs with MMVD.MethodsProspective case‐controlled observational study. In the preliminary study, serum concentrations of leptin, adiponectin, resistin, visfatin, interleukin (IL)‐1β, IL‐6, IL‐10, IL‐18, and tumor necrosis factor‐α were measured. In the subsequent study, MMVD dogs were divided into three groups according to the International Small Animal Cardiac Health Council (ISACHC) classification, and serum concentrations of leptin and adiponectin were measured.ResultsIn the preliminary study, serum leptin and adiponectin concentrations differed significantly between dogs with MMVD and healthy dogs. Serum leptin (P = .0013) concentrations were significantly higher in dogs with MMVD than in healthy dogs, whereas adiponectin (P = .0009) concentrations were significantly lower in dogs with MMVD. However, we observed no significant differences in the other variables. In the subsequent study, dogs classified as ISACHC class 3 had higher serum concentrations of leptin (P = .0022) than healthy dogs but ISACHC class 1 or 2 dogs did not. Serum adiponectin concentrations were significantly lower in ISACHC class 1 (P < .0001) dogs than in healthy dogs, whereas adiponectin concentrations in ISACHC class 3 dogs were significantly higher than in ISACHC class 1 dogs (P = .0081).Conclusions and Clinical ImportanceCirculating concentrations of leptin and adiponectin might be altered in dogs with MMVD.

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Section: Discussionmentioning

confidence: 99%

Serum Concentrations of Leptin and Adiponectin in Dogs with Myxomatous Mitral Valve Disease

Kim

Kang

Jeung

et al. 2016

Veterinary Internal Medicne

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“…In this regard, Liao and his colleagues reported energetic defects in a mice model of transverse aortic constriction in relation to adiponectin deficiency. More recently, increased circulating adiponectin concentrations were associated with metabolic impairments and a hyper‐catabolic state in patients with HFrEF …”

Section: Skeletal Muscle Wasting: Is Adiponectin the Real Culprit?mentioning

confidence: 99%

“…In addition to the well‐described skeletal muscle energetic impairments, the majority of CHF patients develop muscle wasting . Muscle wasting is recognized as a critical component of cachexia contributing to muscle weakness and fatigue .…”

Section: Skeletal Muscle Wasting: Is Adiponectin the Real Culprit?mentioning

confidence: 99%

Adiponectin resistance in skeletal muscle: pathophysiological implications in chronic heart failure

Sente

Berendoncks

Hoymans

et al. 2015

J cachexia sarcopenia muscle

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Skeletal muscle wasting is a common complication of chronic heart failure (CHF) and linked to poor patient prognosis. In recent years, adiponectin was postulated to be centrally involved in CHF‐associated metabolic failure and muscle wasting. This review discusses current knowledge on the role of adiponectin in CHF. Particular emphasis will be given to the complex interaction mechanisms and the intracellular pathways underlying adiponectin resistance in skeletal muscle of CHF patients. In this review, we propose that the resistance process is multifactorial, integrating abnormalities emanating from insulin signalling, mitochondrial biogenesis, and ceramide metabolism.

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“…In studies, higher adiponectin levels were associated with greater radiographic progression in RA 13,14 , suggesting that this adipokine is associated with an aggressive disease phenotype. High adiponectin levels have been considered a biomarker of a catabolic state or cachectic state, such as that seen in starvation 15,16 . Therefore, high levels of adiponectin might be associated with poor prognosis in RA by identifying subjects with a severe phenotype also associated with a catabolic state, muscle wasting, and cachexia.…”

mentioning

confidence: 99%

Insulin-like Growth Factor 1 and Adiponectin and Associations with Muscle Deficits, Disease Characteristics, and Treatments in Rheumatoid Arthritis

Baker

Feldt²,

Mostoufi‐Moab³

et al. 2015

J Rheumatol

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Objective Rheumatoid arthritis (RA) is associated with low muscle mass and density. The objective of our study was to evaluate associations between 2 serum biomarkers [insulin-like growth factor 1 (IGF-1) and adiponectin] and skeletal muscle in RA. Methods Whole-body dual energy X-ray absorptiometry measures of the appendicular lean mass index (ALMI; kg/m2) and total fat mass index (kg/m2), as well as the peripheral quantitative computed tomography measures of the lower leg muscle and fat cross-sectional area (CSA; cm2) and muscle density (an index of fat infiltration) were obtained from 50 participants with RA, ages 18–70 years. Multivariable linear regression analyses evaluated associations between body composition and levels of adiponectin and IGF-1, adjusted for age, sex, and adiposity. Results Greater age was associated with higher adiponectin (p = 0.06) and lower IGF-1 (p = 0.004). Eight subjects had IGF-1 levels below the reference range for their age and sex. These subjects had significantly lower ALMI and muscle CSA in multivariable models. Lower IGF-1 levels were associated with greater clinical disease activity and severity, as well as low ALMI, muscle CSA, and muscle density (defined as 1 SD below normative mean). After adjusting for age and sex, greater adiponectin levels were associated with lower BMI (p = 0.02) as well as lower ALMI, and lower muscle CSA, independent of adiposity (p < 0.05). Only greater Health Assessment Questionnaire scores were significantly associated with lower adiponectin levels. Conclusion Low IGF-1 and greater adiponectin levels are associated with lower muscle mass in RA. Lower IGF-1 levels were seen in subjects with greater disease activity and severity.

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Plasma adiponectin in heart failure with and without cachexia: Catabolic signal linking catabolism, symptomatic status, and prognosis

Cited by 58 publications

References 24 publications

Serum Concentrations of Leptin and Adiponectin in Dogs with Myxomatous Mitral Valve Disease

Serum Concentrations of Leptin and Adiponectin in Dogs with Myxomatous Mitral Valve Disease

Adiponectin resistance in skeletal muscle: pathophysiological implications in chronic heart failure

Insulin-like Growth Factor 1 and Adiponectin and Associations with Muscle Deficits, Disease Characteristics, and Treatments in Rheumatoid Arthritis

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