Plaque Morphology as Predictor of Late Plaque Events in Patients With Asymptomatic Type 2 Diabetes

Abstract

In asymptomatic patients with type 2 diabetes, CTA plaque volume, percent low-density plaque content, and mild calcification predicted late plaque events. The additional presence of luminal stenosis increased the probability of an acute event.

Society of Cardiovascular Computed Tomography / North American Society of Cardiovascular Imaging – Expert Consensus Document on Coronary CT Imaging of Atherosclerotic Plaque

“…36 HRP and quantitative LAP and SC were also predictors of future ACS culprit lesions in a population of patients with diabetes mellitus. 93 Feuchtner et al observed that LAP (<60 HU) and the NRS were the strongest predictors of MACE in a follow-up study of 1,469 patients. 63 Similarly, Nadjiri et al observed similar results, while LAP, NRS, and total plaque volume were all predictive of MACE; LAP had prognostic information beyond traditional assessment of coronary stenosis.…”

Non-invasive imaging of high-risk coronary plaque: the role of computed tomography and positron emission tomography

“…19 Contemporary non-randomised data have consistently demonstrated the prognostic power of CTCA in identifying vulnerable plaque and predicting future acute coronary syndromes. 7, [20][21][22][23][24] These data are supported by analyses from SCOT-HEART and PROMISE. In SCOT-HEART, 608 (34%) patients had adverse plaque features which were associated with a 3-fold higher risk of coronary heart disease death or nonfatal myocardial infarction (HR 3.01, 95% CI 1.61-5.63).…”

Collagen methionine sulfoxide and glucuronidine/LW-1 are markers of coronary artery disease in long-term survivors with type 1 diabetes. The Dialong study

“…Computer Tomography Coronary Angiography (CTCA) is a non-invasive technique that has the advantage of being able to differentiate between absence of CAD and gradually worsening degree of coronary atherosclerosis. The plaque morphology identified also provides valuable information [13]. The associations between MetSO and AGEs with CAD and plaque morphology as defined by CTCA in type 1 diabetes have not been reported previously.…”