Plants that can be Poisonous for Cows. A Review

Mahdy, Cristina El; Popescu, S.; Borda, Cristin

doi:10.15835/buasvmcn-asb:0019

Cited by 3 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diverse symptoms of CNT poisoning have been well described in animals as well as in humans (Edgerton, 1989 ; Mahdy et al., 2017 ), including salivation, nausea, vomiting, abdominal pain, pupil dilation, slow and irregular heartbeat, and hypertension. However, little is known about the occurrence of a hypercoagulable state.…”

Section: Introductionmentioning

confidence: 99%

Convallatoxin, the primary cardiac glycoside in lily of the valley (Convallaria majalis), induces tissue factor expression in endothelial cells

Morimoto

Tatsumi

Yuui

et al. 2021

Veterinary Medicine & Sci

View full text Add to dashboard Cite

Background: Convallotoxin (CNT), present in lily of the valley (Convallaria majalis), is a toxin that causes food poisoning among humans and companion animals. Although various symptoms of CNT poisoning have been well described, hypercoagulability owing to CNT is only empirically known among some veterinarians, and the underlying mechanism remains to be elucidated. CNT exerts cytotoxic effects on endothelial cells.Objectives: This study aimed to determine whether CNT induces the expression of tissue factor (TF), a potent initiator of the extrinsic coagulation cascade, in endothelial cells and leads to a hypercoagulable state.Methods: Human umbilical vein endothelial cells (HUVECs) were used for in vitro experiments. HUVECs were treated with or without CNT (50 and 100 nM) for 4 h. Phosphate-buffered saline was used as a control. Cell viability was determined using the WST-8 assay. Quantitative real-time polymerase chain reaction was performed to determine TF mRNA expression. TF protein expression was observed using a laser scanning confocal microscope. Results:The viability of HUVECs significantly reduced after CNT treatment compared with that of non-treated cells (p < 0.05). Moreover, a significant increase in TF mRNA and protein expression was observed after 4 h of CNT treatment. CNT elicited these effects in a dose-dependent manner.Conclusions: TF expression induced by CNT in endothelial cells can contribute to the development of a hypercoagulable state. The present study partially revealed the mechanisms underlying the CNT-induced hypercoagulable state. The findings can contribute to the development of a novel therapy for lily of the valley poisoning.

show abstract

Section: Introductionmentioning

confidence: 99%

Convallatoxin, the primary cardiac glycoside in lily of the valley (Convallaria majalis), induces tissue factor expression in endothelial cells

Morimoto

Tatsumi

Yuui

et al. 2021

Veterinary Medicine & Sci

View full text Add to dashboard Cite

show abstract

“…Atropa Belladonna although it contains toxic alkaloids such as: atropine, scopolamine, hyosciamine, beladonine and nicotine (El Mahdy et al, 2017), it is used to treat systemic symptoms, localized fever of a reddened and painful tissue, of Seeds of Papaver somniferum (opium poppy) administered as feed are used in cases of mastitis and inflammation of udder (Bartha et al, 2015).…”

Section: Plants Used For Treatment Of Mastitismentioning

confidence: 99%

Plants Used in Ethnoveterinary Medicine in Cows. A Review

Mahdy¹,

Popescu²,

Borda³

et al. 2019

BUASVMCN-ASB

Self Cite

View full text Add to dashboard Cite

Through the regulations CE.834/2007 and implementing rules CE 889/2008, regarding the organic production the treatment with antibiotics in livestock are extremely limited. Therefore plants can replace medicines in treatment of certain conditions. The plants used in ethnoveterinary medicine are varied depending on area, but this review refers to plants existing in Romania identical to those existing in other areas of the world, some being used only in certain areas, others in areal extended, but it can be a start for farmers to seek natural remedies. There are 66 plant species which belong to a large number of families, but most plants belong to the family Asteraceae (11 -16.66%), followed by species of family Solanaceae (6.06%) and family: Malvaceae, Adoxaceae, Convolvulacea, Euphorbiaceae, Fabaceae with 3 species each (4.54%). Of the plants, 11 species (16.8%) are considered to be toxic and 18 (27.2%) potentially toxic but, have therapeutic effect in extremely small amounts. Regardless of the area, plants are used in the same treatments in different form.

show abstract