Plants antioxidants: From laboratory to clinic

Rafieian-Kopaei, Mahmoud; Baradaran, Azar; Mahmoud, Rafieian

doi:10.5812/nephropathol.12116

Cited by 117 publications

(77 citation statements)

References 11 publications

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“…Hence, controlling these mechanisms seems to be effective to control of CI-AKI. Based on the antioxidant activity of many herbs (10,11), they can prevention CI-AKI by reduction of these mechanisms, especially by prevention of free radicals formation. The positive effects of B. vulgaris on in prevention and treatment of the toxicity induced by free radicals in kidney stone disease have been reported, previously (21).…”

Section: Discussionmentioning

confidence: 99%

“…Herbal medicines are a rich source of phenolic compounds with antioxidant activities and most of their beneficial effects have been related to their antioxidant activities (9). On the other hand the status of medicinal plants and their antioxidant effects in reducing kidney injuries have already been confirmed (10,11). Berberis vulgaris is one of the medicinal plants with potent antioxidant effect (12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

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The preventive effect of Berberis vulgaris extract on contrastinduced acute kidney injury

Asgharian¹,

Lorigooini²,

Rafieian³

et al. 2017

J Nephropathol

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The preventive effect of Berberis vulgaris extract on contrastinduced acute kidney injury

Asgharian¹,

Lorigooini²,

Rafieian³

et al. 2017

J Nephropathol

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“…However, currently many drugs are used to cure hyperlipidemia; all of them have some side effects (6)(7)(8)(9). On the other hand, medicinal plants have generally less side effects and are accepted by people as an alternative treatment since ancient times (10)(11)(12)(13)(14)(15)(16)(17)(18). Furthermore, recent trends in treating and controlling diseases tend to favor natural antioxidant compounds more than synthetic ones (19)(20)(21)(22)(23)(24)(25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

Effect of Kelussia odoratissima Mozaffarian on Lipid and Glucose Profile

Shariati

Asgari

Gheshlaghi³

et al. 2015

Shiraz E-Med J

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Background: Flavonoids are a group of polyphenolic compounds with antioxidant properties that help reduce cardiovascular risk factors. Kelussia odoratissima is a flavonoid-containing plant, the effect of which was analyzed on decreasing blood lipid levels in mice. Objectives: The present study was carried out with the aim of determining the anti-hyperlipidemia effects of this herb on mice. Materials and Methods:In this preclinical study, 70 Balb/c mice were divided to five 14-member groups and received normal diet, normal diet containing 5% olive oil, high cholesterol (2% cholesterol and 5% olive oil) diet and high cholesterol diet accompanied by Kelussia odoratissima 10% or 20% hydro-alcoholic extract. After two weeks, blood samples were taken and cholesterol, triglyceride, low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL), and fasting blood sugar (FBS) were measured. Results: In this animal model, the levels of all serum lipids including cholesterol, HDL, VLDL, LDL, triglyceride and FBS had a significant decrease two weeks after the beginning of the study. Moreover, at the same time, in the group that received 20% hydro-alcoholic extract, the serum levels of cholesterol, HDL and LDL had a significant decrease (P < 0.05). Conclusions: Kelussia odoratissima might have a desirable effect on serum lipid profile and might have beneficial effects on hyperlipidemic patients.

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“…This can be attributed to the oxygen free radicals produced by CP (52), because CP can cause oxidative stress in addition to enzymatic and hormonal alterations (53). Antioxidants are able to inhibit oxygen free radicals, reduce oxidative stress, and minimize associated complications (54)(55)(56)(57)(58). The plants and plant-based compounds, presented in this review article, are highly useful to reduce oxidative stress.…”

Section: (34)mentioning

confidence: 99%