Effect of Kelussia odoratissima Mozaffarian on Lipid and Glucose Profile

Abstract

Background: Flavonoids are a group of polyphenolic compounds with antioxidant properties that help reduce cardiovascular risk factors. Kelussia odoratissima is a flavonoid-containing plant, the effect of which was analyzed on decreasing blood lipid levels in mice. Objectives: The present study was carried out with the aim of determining the anti-hyperlipidemia effects of this herb on mice. Materials and Methods:In this preclinical study, 70 Balb/c mice were divided to five 14-member groups and received normal diet, normal diet containing 5% olive oil, high cholesterol (2% cholesterol and 5% olive oil) diet and high cholesterol diet accompanied by Kelussia odoratissima 10% or 20% hydro-alcoholic extract. After two weeks, blood samples were taken and cholesterol, triglyceride, low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL), and fasting blood sugar (FBS) were measured. Results: In this animal model, the levels of all serum lipids including cholesterol, HDL, VLDL, LDL, triglyceride and FBS had a significant decrease two weeks after the beginning of the study. Moreover, at the same time, in the group that received 20% hydro-alcoholic extract, the serum levels of cholesterol, HDL and LDL had a significant decrease (P < 0.05). Conclusions: Kelussia odoratissima might have a desirable effect on serum lipid profile and might have beneficial effects on hyperlipidemic patients.

Cumin (Cuminum cyminum L.) is a safe approach for management of lipid parameters: A systematic review and meta‐analysis of randomized controlled trials

“…With economic development and lifestyle changes, dyslipidemia has become more common in all over the globe (Kafeshani, Mirhosseini, Momeni, Rabiei, & Rafieian‐Kopaei, ; Nelson, Rochelau, & Nicholls, ). Dyslipidemia can trigger the development of different chronic disorders including cardiovascular diseases, metabolic syndrome, Type 2 diabetes, and stroke (Hadi et al, ; Nelson et al, ; Rastegari, ; Shahreza, ). Furthermore, it increases mortality rate and subsequently brings a high cost to societies (Grundy, ).…”

Solubility of calcium oxalate and calcium phosphate crystallization in the presence of crude extract and fractions from Kelussia odoratissima Mozaff

“…[11] According to the research conducted on the pharmacological properties of this plant, analgesic and anti-inflammatory effects, [13] sedative effect, [14] fibrinolytic effect, [6] activity to decrease the secretion of acid and pepsin, [15] antihyperlipidemic effect, [16] inhibitory effect on contractions of uterus and ileum, [17,18] and memory boosting effect [19] have been reported. It contains total phenolic, flavonoid, and flavonol contents with the values of 96.2%, 56.1%, and 32.9%, respectively, and phthalides and fatty acids, that its cancer prevention [16] and liver protection effect, [20] have been attributed to. Furthermore, due to phenolic compounds and flavonoids, this plant has free radical scavenging and antioxidant effects.…”

“…[21] In traditional medicine, K. odoratissima is used for treating some disorders such as rheumatism, colds, cough, hypertension, hyperlipidemia, diabetes, and stomachache. [16] In 2010, Byahatti et al investigated the effect of total extract and fractions containing phenolic compounds of leaves of Bergenia ciliata (Haw.) Sternb.…”