Plant tumors and their relation to cancer

Levine, Michael

doi:10.1007/bf02870154

Cited by 22 publications

(8 citation statements)

References 40 publications

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“…209-211 Crown-gall tumors arise form bacterial infections that enter damaged areas of the plant leading to plant cell proliferation. The mechanisms by which bacteria induce crown-gall disease in plants are similar to those by which viruses induce tumors in animals.…”

Section: The Absence Of Metastases In Crown-gall Plant Tumorsmentioning

confidence: 99%

“…The mechanisms by which bacteria induce crown-gall disease in plants are similar to those by which viruses induce tumors in animals. 14,211 Robinson first suggested that Warburg’s cancer theory might account for the abnormal cell proliferation in crown-gall tumors following bacterial damage to respiration in the affected plant cells. 209 Indeed, defects in mitochondrial morphology and energy metabolism were later described in crown-gall tumors.…”

Section: The Absence Of Metastases In Crown-gall Plant Tumorsmentioning

confidence: 99%

“…14 However, these tumors do not express invasion or metastasis. 211 With the exception of metastasis and invasion, the abnormalities in growth and physiology are similar in crown-gall disease and in animal tumors. 14 If metastasis arises from damaged respiration in macrophages or in their fusion hybrids as we discussed above, then it becomes clear why the grown-gall tumors do not display invasion or metastasis despite expressing other hallmarks of tumors.…”

Section: The Absence Of Metastases In Crown-gall Plant Tumorsmentioning

confidence: 99%

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On the Origin of Cancer Metastasis

2013

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Metastasis involves the spread of cancer cells from the primary tumor to surrounding tissues and to distant organs and is the primary cause of cancer morbidity and mortality. In order to complete the metastatic cascade, cancer cells must detach from the primary tumor, intravasate into the circulatory and lymphatic systems, evade immune attack, extravasate at distant capillary beds, and invade and proliferate in distant organs. Currently, several hypotheses have been advanced to explain the origin of cancer metastasis. These involve an epithelial mesenchymal transition, an accumulation of mutations in stem cells, a macrophage facilitation process, and a macrophage origin involving either transformation or fusion hybridization with neoplastic cells. Many of the properties of metastatic cancer cells are also seen in normal macrophages. A macrophage origin of metastasis can also explain the long-standing “seed and soil” hypothesis and the absence of metastasis in plant cancers. The view of metastasis as a macrophage metabolic disease can provide novel insight for therapeutic management.

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Section: The Absence Of Metastases In Crown-gall Plant Tumorsmentioning

confidence: 99%

Section: The Absence Of Metastases In Crown-gall Plant Tumorsmentioning

confidence: 99%

Section: The Absence Of Metastases In Crown-gall Plant Tumorsmentioning

confidence: 99%

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On the Origin of Cancer Metastasis

2013

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“…Smith (1923) compared crown-gall tissues with embryonic tissues, and Banfield (1935) in his study of cane gall of black raspberry, reported that the tumorous tissues were composed of cells which were in every respect comparable to cells of the normal meristem. Levine (1936) considered crown-gall tissue essentially a fundamental meristem. White (1945) used the respiratory behavior of growing points of stems and of young inflorescences for comparison with that of tumors because the former are rapidly growing tissues which might be presumed to bear a closer physiological resemblance to tumorous tissue than does mature stem tissue.…”

mentioning

confidence: 99%

Effects of Maleic Hydrazide on Initiation and Development of Tomato Crown-Gall Tumors

Klein

1952

American Journal of Botany

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“…Bergey et al has been studied extensively. The early literature on crowngall has been reviewed by Riker and Berge (1935) and by Levine (1936). Although much work has been done with crown-gall bacteria, little is known yet about the physiology of the host cells, because of certain technical difficulties involved in such studies.…”

mentioning

confidence: 99%