Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNA

Jmii, Souleimen; Cappadocia, Laurent

doi:10.3389/fpls.2021.652170

Cited by 17 publications

(12 citation statements)

References 89 publications

(134 reference statements)

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“…SUMOylation protects conjugated protein from degradation by blocking the lysine residues that can be ubiquitinated ( Roy and Sadanandom, 2021 ). Thus, SUMOylation of ICE1 by SAP AND MIZ1 DOMAIN-CONTAINING LIGASE 1 (SIZ1; Jmii and Cappadocia, 2021 ) protects ICE1 from degradation through the 26S proteosomic degradation pathway. Expression of CBF/DREB1 and the downstream COR genes was increased while the expression of MYB15 was suppressed due to SIZ1 conjugation of ICE1, enhancing the tolerance to low temperature ( Miura et al, 2007 ).…”

Section: Controlled Of Transcription Factor Levels Through Differenti...mentioning

confidence: 99%

Fine-Tuning Cold Stress Response Through Regulated Cellular Abundance and Mechanistic Actions of Transcription Factors

2022

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Inflictions caused by cold stress can result in disastrous effects on the productivity and survival of plants. Cold stress response in plants requires crosstalk between multiple signaling pathways including cold, heat, and reactive oxygen species (ROS) signaling networks. CBF, MYB, bHLH, and WRKY families are among the TFs that function as key players in the regulation of cold stress response at the molecular level. This review discusses some of the latest understanding on the regulation of expression and the mechanistic actions of plant TFs to address cold stress response. It was shown that the plant response consists of early and late responses as well as memory reprogramming for long-term protection against cold stress. The regulatory network can be differentiated into CBF-dependent and independent pathways involving different sets of TFs. Post-transcriptional regulation by miRNAs, control during ribosomal translation process, and post-translational regulation involving 26S proteosomic degradation are processes that affect the cellular abundance of key regulatory TFs, which is an important aspect of the regulation for cold acclimation. Therefore, fine-tuning of the regulation by TFs for adjusting to the cold stress condition involving the dynamic action of protein kinases, membrane ion channels, adapters, and modifiers is emphasized in this review.

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Section: Controlled Of Transcription Factor Levels Through Differenti...mentioning

confidence: 99%

Fine-Tuning Cold Stress Response Through Regulated Cellular Abundance and Mechanistic Actions of Transcription Factors

2022

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“…Abiotic stress is essentially any environmental condition that negatively affects the growth and general development of a plant [ 3 ]. This may range from mechanical disturbances, such as strong winds, to rapid changes in light conditions on a cloudy day, but generally it is mostly connected with severe stress conditions, such as soil salinity, heat waves, and drought stress [ 3 , 4 , 5 ]. The sessile lifestyle of plants makes it impossible for them to avoid these stressors by simply changing their location; hence, they need to have strategies in place to rapidly respond to changes in their environment in order to survive and sustain their growth.…”

Section: Introductionmentioning

confidence: 99%

Plant E3 Ligases and Their Role in Abiotic Stress Response

Al-Saharin

Hellmann

Mooney

2022

Cells

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Plants, as sessile organisms, have limited means to cope with environmental changes. Consequently, they have developed complex regulatory systems to ameliorate abiotic stresses im-posed by environmental changes. One such system is the ubiquitin proteasome pathway, which utilizes E3 ligases to target proteins for proteolytic degradation via the 26S proteasome. Plants ex-press a plethora of E3 ligases that are categorized into four major groups depending on their structure. They are involved in many biological and developmental processes in plants, such as DNA repair, photomorphogenesis, phytohormones signaling, and biotic stress. Moreover, many E3 ligase targets are proteins involved in abiotic stress responses, such as salt, drought, heat, and cold. In this review, we will provide a comprehensive overview of E3 ligases and their substrates that have been connected with abiotic stress in order to illustrate the diversity and complexity of how this pathway enables plant survival under stress conditions.

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“…E3 ubiquitin ligases, the most abundant eukaryotic proteins (Mazzucotelli et al 2006 ; Liyuan et al 2013; Michael et al 2015 ), catalyze the covalent attachment of ubiquitin to substrates with the help of E1 (ubiquitin-activating enzyme) and E2 (ubiquitin-conjugating enzyme) proteins (Buetow and Huang 2016 ). A wide variety of ubiquitination processes participate in numerous biological pathways (Jmii and Cappadocia 2021 ; Wu et al 2021 ; Liu et al 2021 ; Uchida and Kitagawa 2016 ), and the predominant function, mediated by Lys48-linked ubiquitination, is to target proteins to the proteasome for degradation (Hiranyakorn et al 2020 ). Other types of linkages, e.g., Lys63-linkages, signal substrates for non-degradative functions, such as protein assembly or modification (Chen and Sun 2009 ) (Swatek and Komander 2016 ); or chromatin modelling or repair (Nakazawa et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Rice SIAH E3 Ligases Interact with RMD Formin and Affect Plant Morphology

Chang

Huang

Wang

et al. 2022

Rice

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Formins are actin-binding proteins that are key to maintaining the actin cytoskeleton in cells. However, molecular mechanisms controlling the stability of formin proteins in plants remain unknown. Here, we have identified six rice SIAH-type E3 ligases, named RIP1-6 (RMD Interacting Protein 1–6) respectively, with ubiquitination enzyme activity in vitro. All six proteins can form homo- and hetero-dimers with themselves, and hetero-dimers with type II formin RMD/OsFH5. In vivo assays showed that RIP1-6 proteins localize in the cytoplasm with a punctate distribution, and all of them interact with RMD to change its native diffuse cytoplasmic localization to match that of RIP1-6. To our surprise, degradation experiments revealed that RIP1, RIP5, and RIP6 decrease rather than increase the degradation rate of RMD. Genetic analyses revealed redundancy between these six genes; either single or double mutants did not show any obvious phenotypes. However, the sextuple rip1-6 mutant displayed dwarf height, wrinkled seeds and wider leaves that were similar to the previously reported rmd mutant, and defective microfilaments and increased flag leaf angles that were not reported in rmd mutant. Collectively, our study provides insights into the mechanisms determining formin protein stability in plants.

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Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNA

Cited by 17 publications

References 89 publications

Fine-Tuning Cold Stress Response Through Regulated Cellular Abundance and Mechanistic Actions of Transcription Factors

Fine-Tuning Cold Stress Response Through Regulated Cellular Abundance and Mechanistic Actions of Transcription Factors

Plant E3 Ligases and Their Role in Abiotic Stress Response

Rice SIAH E3 Ligases Interact with RMD Formin and Affect Plant Morphology

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