Plant secondary metabolites against arthropods of medical importance

Ntalli, Nikoletta; Koliopoulos, George; Γιατρόπουλος, Αθανάσιος; Menkissoglu‐Spiroudi, Urania

doi:10.1007/s11101-019-09647-7

Cited by 30 publications

(19 citation statements)

References 102 publications

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“…In recent years, interest in plant-based insecticides has grown because of this development of resistance and off-target effects of synthetic pesticides [5,6,7,8]. Secondary metabolites of plants have been shaped by millions of years of natural selection to protect plants against herbivores, including insects.…”

Section: Introductionmentioning

confidence: 99%

Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (Cinnamosma sp.) Extracts and Drimane-Type Sesquiterpenes against Aedes aegypti Mosquitoes

Inocente

Nguyen

Manwill

et al. 2019

Insects

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The overuse of insecticides with limited modes of action has led to resistance in mosquito vectors. Thus, insecticides with novel modes of action are needed. Secondary metabolites in Madagascan plants of the genus Cinnamosma (Canellaceae) are commonly used in traditional remedies and known to elicit antifeedant and toxic effects in insect pests. Here we test the hypothesis that extracts of Cinnamosma sp. enriched in drimane sesquiterpenes are toxic and/or antifeedant to the yellow fever mosquito Aedes aegypti. We show that the bark and root extracts, which contain a higher abundance of drimane sesquiterpenes compared to leaves, were the most efficacious. Screening isolated compounds revealed cinnamodial to be the primary driver of adulticidal activity, whereas cinnamodial, polygodial, cinnafragrin A, and capsicodendrin contributed to the larvicidal activity. Moreover, an abundant lactone (cinnamosmolide) in the root extract synergized the larvicidal effects of cinnamodial. The antifeedant activity of the extracts was primarily contributed to cinnamodial, polygodial, and cinnamolide. Parallel experiments with warburganal isolated from Warburgia ugandensis (Canellaceae) revealed that aldehydes are critical for—and a hydroxyl modulates—insecticidal activity. Our results indicate that plant drimane sesquiterpenes provide valuable chemical platforms for developing insecticides and repellents to control mosquito vectors.

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Section: Introductionmentioning

confidence: 99%

Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (Cinnamosma sp.) Extracts and Drimane-Type Sesquiterpenes against Aedes aegypti Mosquitoes

Inocente

Nguyen

Manwill

et al. 2019

Insects

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“…Acaricides are pesticides designed specifically for mites and ticks. Natural compounds of botanical origin are increasingly being investigated to develop novel biopesticides for agriculture [ 122 , 175 ]. The growth of biopesticides is projected to outpace the synthetic pesticides, with annual growth rates of between 10% and 20% [ 176 ].…”

Section: From the Bench To The Market: A Long Rough Road Of Scalinmentioning

confidence: 99%

Plant-Derived Natural Compounds for Tick Pest Control in Livestock and Wildlife: Pragmatism or Utopia?

Quadros¹,

Johnson

Whitney³

et al. 2020

Insects

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Ticks and tick-borne diseases are a significant economic hindrance for livestock production and a menace to public health. The expansion of tick populations into new areas, the occurrence of acaricide resistance to synthetic chemical treatments, the potentially toxic contamination of food supplies, and the difficulty of applying chemical control in wild-animal populations have created greater interest in developing new tick control alternatives. Plant compounds represent a promising avenue for the discovery of such alternatives. Several plant extracts and secondary metabolites have repellent and acaricidal effects. However, very little is known about their mode of action, and their commercialization is faced with multiple hurdles, from the determination of an adequate formulation to field validation and public availability. Further, the applicability of these compounds to control ticks in wild-animal populations is restrained by inadequate delivery systems that cannot guarantee accurate dosage delivery at the right time to the target animal populations. More work, financial support, and collaboration with regulatory authorities, research groups, and private companies are needed to overcome these obstacles. Here, we review the advancements on known plant-derived natural compounds with acaricidal potential and discuss the road ahead toward the implementation of organic control in managing ticks and tick-borne diseases.

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“…It has been reported that insecticide use has detrimental effects on non-target organisms, for example imidacloprid on honey bee ( Apis mellifera ) [ 17 ], damselfly ( Ischnura senegalensis ) [ 18 ], fathead minnow ( Pimephales promelas ), or the amphipod ( Hyalella azteca ) [ 19 ]. Thus, there is a need for new and complementary methods for controlling insect vectors, and essential oils have shown promise as renewable and environmentally-safe alternatives to the use of synthetic insecticides [ 20 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Premna Species in Vietnam: Essential Oil Compositions and Mosquito Larvicidal Activities

Hùng

Huong

Chung

et al. 2020

Plants

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Essential oils have emerged as viable alternatives to synthetic insecticides for control of mosquito-borne pathogens. The leaf essential oils of eight species of Premna (Lamiaceae) growing in central Vietnam have been obtained by hydrodistillation and analyzed by gas chromatography–mass spectrometry. Sesquiterpene hydrocarbons dominated most of the Premna essential oils, with the notable exception of Premnamekongensis from Ngoc Linh Nature Reserve, which had α-pinene as the major component. Larvicidal activities against Aedes aegypti have been determined and all of the Premna essential oils showed larvicidal activity with 24-h LC50 < 65 μg/mL. The leaf essential oils of Premnacambodiana from Chu Mom Ray National Park and Premnamekongensis from Ngoc Linh Nature Reserve showed the best larvicidal activities with 24-h LC50 of 16.8 and 18.0 μg/mL, respectively. The essential oil compositions and larvicidal activities of P. cambodiana, Premna flavescens, Premnamaclurei, P. mekongensis, and Premnapuberula are reported for the first time. Although the larvicidal activities of Premna leaf essential oils are promising, the essential oil yields are relatively low (0.10–0.25%).

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Plant secondary metabolites against arthropods of medical importance

Cited by 30 publications

References 102 publications

Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (Cinnamosma sp.) Extracts and Drimane-Type Sesquiterpenes against Aedes aegypti Mosquitoes

Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (Cinnamosma sp.) Extracts and Drimane-Type Sesquiterpenes against Aedes aegypti Mosquitoes

Plant-Derived Natural Compounds for Tick Pest Control in Livestock and Wildlife: Pragmatism or Utopia?

Premna Species in Vietnam: Essential Oil Compositions and Mosquito Larvicidal Activities

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