Plant Regeneration from Leaf and Root Cultures of Lycoris chejuensis via Bulblet Formation

오명진,; 박종미,; 태경환,; 유장렬,; 김석원,

doi:10.5010/jpb.2007.34.3.223

Cited by 3 publications

(5 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 CJ is another Lycoris species and originates from the Jeju Island of Korea. 6,7 The Lycoris genus was found to have a wide range of biological activities because its active compounds generally contain seven representative alkaloids, including lycorine, homolycorine, hemeanthamine, tazettine, montanine, galanthamine, and narciclasine compounds. 8−11 Among these alkaloids, galanthamine, as an acetylcholinesterase (AchE) inhibitor, has been approved by the U.S. Food and Drug Administration (FDA) to treat Alzheimer's disease (AD) in the U.S.A. and Europe.…”

Section: ■ Introductionmentioning

confidence: 99%

“…In addition, Lycoris bulb is rich in starch and has thus been traditionally used as a hunger crop after boiling; Lycoris chejuensis K. Tae et S. Ko (CJ) has also been used for this purpose . CJ is another Lycoris species and originates from the Jeju Island of Korea. , The Lycoris genus was found to have a wide range of biological activities because its active compounds generally contain seven representative alkaloids, including lycorine, homolycorine, hemeanthamine, tazettine, montanine, galanthamine, and narciclasine compounds. − Among these alkaloids, galanthamine, as an acetylcholinesterase (AchE) inhibitor, has been approved by the U.S. Food and Drug Administration (FDA) to treat Alzheimer’s disease (AD) in the U.S.A. and Europe. Interestingly, in addition to its anti-AD effect, galanthamine also significantly inhibited neuroinflammation by attenuating tumor necrosis factor α (TNF-α) and nitric oxide (NO) production in murine microglia .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

7-Deoxy-trans-dihydronarciclasine Isolated from Lycoris chejuensis Inhibits Neuroinflammation in Experimental Models

Zhao

Zhang

et al. 2019

J. Agric. Food Chem.

View full text Add to dashboard Cite

Overactivated microglia and persistent neuroinflammation hold an important role in the pathophysiology of neurodegenerative diseases. The extract of Lycoris chejuensis (CJ) and its active compound, 7-deoxy-trans-dihydronarciclasine (named E144), attenuated expressions of pro-inflammatory factors, including nitric oxide, prostaglandin E2, inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor α (TNF-α), and interleukin 6, secreted by lipopolysaccharide-activated BV-2 microglial cells, as measured by an enzyme-linked immunosorbent assay or western blotting. In contrast, CJ extract and E144 promoted the secretion of the anti-inflammatory cytokine, interleukin 10. Moreover, we found that E144 attenuated the expression of TNF-α and COX-2 in the cerebral cortex of lipopolysaccharide-treated mice and/or T2576 transgenic mice as well as reduced the reactive immune cells visualized by ionized calcium-binding adaptor molecule 1. Our results suggest the possibility of E144 to serve as a potential anti-neuroinflammatory agent by preventing excess production of pro-inflammatory factors.

show abstract

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

7-Deoxy-trans-dihydronarciclasine Isolated from Lycoris chejuensis Inhibits Neuroinflammation in Experimental Models

Zhao

Zhang

et al. 2019

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…(Abdel-Rahman et al, 2017;Santos et al, 2015), Sternbergia fischeriana (Kizil et al, 2014), and Zephyranthes rosea (Mujib et al, 2014). However, regeneration of shoots has also been possible from leaf explants of Cyrtanthus mackenii (Kumari et al, 2017) and Lycoris chejuensis (Oh et al, 2007) and from the peduncles of Clivia miniata (Ran & Simpson, 2005) and Heamanthus coccineus (Ziv & Lilien-Kipnis, 2000).…”

Section: Discussionmentioning

confidence: 99%

Impact of jasmonates, salicylic acid, and fungal elicitor on the health of Hippeastrum hybridum bulbs achieved by in vitro procedure

Trejgell,

Szmidt-Jaworska

2024

Acta Agro

View full text Add to dashboard Cite

Production of high-quality vigorous plant materials obtained by micropropagation requires not only a good regeneration procedure but also efficient ways to enhance their post-transplanting ability to cope with external environmental factors. There is increasing interest in Hippeastrum hybridum on the horticultural market. However, the traditional method of cultivation using seeds and bulbs does not meet the growing demand and requirements of available priming procedures, thus leading to a search for more effective methods of reproduction. The aim of the study was to assess the morphogenetic abilities of bulb and flower explants for regeneration and investigate whether the enrichment of the multiplication process by exposure to elicitors will improve the health of the obtained plants through faster synthesis of phytoalexin. The study revealed that high regeneration efficiency can be obtained by using twin-scales, peduncles, and receptacles. Over 76% of explants were capable of bulblet induction and the micropropagation rates were 2.3, 2.7, and 5.0, respectively. At the rooting stage, the use of regulator-free medium was required, yielding a high percentage of rooted shoots of over 90% (shoots obtained on twin-scales and peduncles). The materials obtained in vitro did not differ morphologically from the initial materials. However, it was noted that, after exposure to the Phoma narcissi fungal elicitor or to jasmonic acid (JA) and jasmonic acid methyl ester (MeJA), the in vitro-derived bulbs were able to synthesize phytoalexin with higher efficiency than the untreated ones. Therefore, the described methods can be useful for H. hybridum multiplication. Moreover, the enrichment of the multiplication process with the stage of exposure to elicitors ensures initial immunity of H. hybridum to the pathogen Phoma narcissi, which can be used as a priming procedure.

show abstract

“…22,23 Because of their rich starch contents, Lycoris species plants, including CJ, have been traditionally used for hunger crops. 24,25 In this study, we found that the CJ extract potently lowered Aβ levels in vitro and in vivo. CJ was also observed to decrease several byproducts of secretase activity.…”

Section: ■ Introductionmentioning

confidence: 92%

“…However, there has been no report on whether Lycoris directly affects AD pathological pathways, such as the formation of Aβ. More specifically, no biological effects have been reported for Lycoris chejuensis K. Tae et S. Ko (CJ), which originates from Jeju Island in Korea. , Because of their rich starch contents, Lycoris species plants, including CJ, have been traditionally used for hunger crops. , …”

Section: Introductionmentioning

confidence: 99%

Effect of Lycoris chejuensis and Its Active Components on Experimental Models of Alzheimer’s Disease

Kim

Park

Chun

et al. 2015

J. Agric. Food Chem.

View full text Add to dashboard Cite

We found that an extract of Lycoris chejuensis and its three isolated active components, narciclasine, 7-deoxynarciclasine, and 7-deoxy-trans-dihydronarciclasine, each significantly reduced the formation of amyloid-β peptides in HeLa cells transfected with an amyloid precursor protein carrying the Swedish mutation up to 45 ± 3.6%. The extract down-regulated amyloid precursor protein, especially the mature form by up to 88%, and reduced the ability of secretases to generate toxic amyloid-β. Double-transgenic mice treated with the extract for 4 months also showed significantly reduced levels of amyloid-β and plaques while exhibiting improved memory functions in the Morris water maze and novel object recognition tests. In conclusion, the extract and isolated active components of L. chejuensis decreased the production of amyloid-β by attenuating amyloid precursor protein levels. Furthermore, the extract improved the disrupted memory functions in animals while inhibiting amyloid plaque formation. Thus, this extract, as well as its active components, could prove beneficial in the treatment of Alzheimer's disease.

show abstract

Plant Regeneration from Leaf and Root Cultures of Lycoris chejuensis via Bulblet Formation

Cited by 3 publications

References 4 publications

7-Deoxy-trans-dihydronarciclasine Isolated from Lycoris chejuensis Inhibits Neuroinflammation in Experimental Models

7-Deoxy-trans-dihydronarciclasine Isolated from Lycoris chejuensis Inhibits Neuroinflammation in Experimental Models

Impact of jasmonates, salicylic acid, and fungal elicitor on the health of <i>Hippeastrum hybridum</i> bulbs achieved by <i>in vitro</i> procedure

Effect of Lycoris chejuensis and Its Active Components on Experimental Models of Alzheimer’s Disease

Contact Info

Product

Resources

About