Plant Polysaccharides Blended Ionotropically Gelled Alginate Multiple Unit Systems for Sustained Drug Release

Pal, Dilipkumar; Nayak, Amit Kumar

doi:10.1002/9781119441632.ch119

Cited by 13 publications

(2 citation statements)

References 131 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As reported in various studies, they are economical, as well as exhibiting many benefits, such as biodegradability, ease of availability, non-toxicity, etc. [1,2]. Despite having such attractive characteristics, natural polymers possess drawbacks such as uncontrolled hydration, microbial contamination, and batch-to-batch variation.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Microwave-Controlled Polyacrylamide Graft Copolymer of Tamarind Seed Polysaccharide

et al. 2022

View full text Add to dashboard Cite

The main objective of the study was to prepare tamarind seed polysaccharide grafted copolymers of polyacrylamide (TSP-g-Am) using a 32 factorial design. Tamarind seed polysaccharide (TSP) was extracted, and grafted copolymer of TSP was prepared using polyacrylamide as copolymer and ceric ammonium nitrate as initiator. Various batches (F1-F9) of TSP-g-Am were prepared, among which F1 showed highest grafting efficiency; hence, the prepared TSP-g-Am (F1) was evaluated for grafting efficiency, conversion, effect of initiator and further characterized using SEM analysis, contact angle determination, DSC analysis, swelling index, swelling and deswelling, and chemical resistance. The contact angle of TSP was found to be 81 ± 2, and that of TSP-g-Am (F1) was found to be 74 ± 2, which indicates that the wetting ability of the grafted copolymer was less than that of the native polymer. The results of thermal analysis indicated that TSP-g-Am had a more stable molecular structure than TSP. The morphology of the grafted polymer was observed from SEM images, and it was observed that the particles was asymmetrical. Antimicrobial activity was also found in the grafted copolymer. The present study concludes that the TSP-g-Am showed an excellent performance in thermal stability and swelling capacity compared with TSP. The detailed structural characteristics, as well as the excellent thermal stability and swelling capacities, will make it beneficial to use the synthesised copolymer as a precursor for the production of large-scale eco-friendly advanced materials with a wide range of applications, acting as a stabiliser, thickener, binder, release retardant, modifier, suspending agent, viscosity enhancer, emulsifying agent, or carrier for novel drug delivery systems in oral, buccal, colon, and ocular systems, and in nanofabrication and wound dressing, and it is also becoming an important part of food, cosmetics, confectionery, and bakery.

show abstract

Section: Introductionmentioning

confidence: 99%

Characterization of Microwave-Controlled Polyacrylamide Graft Copolymer of Tamarind Seed Polysaccharide

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Plant polysaccharides are a popular natural bio-polysaccharide group, which are non-toxic, biodegradable, less expensive and freely available in the natural sources. [8][9][10][11] These are found mainly in exudates materials, fruits, seeds, roots, rhizomes, leaves, pods, etc. 12 The fact for increasing significance of the use of plant polysaccharides is that the plant sources are renewable if cultivated or harvested in a sustainable manner and they are able to provide a constant supply of raw materials.…”

Section: Introductionmentioning

confidence: 99%

Tamarind Seed Polysaccharide: An Emerging Excipient for Pharmaceutical Use

Nayak¹,

Pal²

2017

IJPER

Self Cite

View full text Add to dashboard Cite

Currently, various plant polysaccharides have been studied for their diverse applications as excipients like binders, granulating agents, disintegrants, emulsifiers, suspending agents, gelling agents, mucoadhesive agents, matrix-formers, release retardants, enteric resistants, etc., in various pharmaceutical dosage forms. Among these, tamarind seed polysaccharide is an emerging excipient, which is beingused and investigated for the preparation of various dosage forms like suspensions, emulsions, tablets, gels, creams, beads, spheroids, microparticles, nanoparticles, ophthalmic preparations, and buccal patches, etc. The current chapter deals with a comprehensive and useful discussion on pharmaceutical applications of tamarind seed polysaccharide withits some important features like source, isolation, chemical composition and properties.

show abstract

Calcium Alginate‐Sago Starch Particles for Sustained Drug Release: Preparation and In Vitro Characterization

Indu,

Maiti,

Nayak

et al. 2024

Starch Stärke

View full text Add to dashboard Cite

In the current work, the efficacy of sago starch as potential biopolymer‐blends with sodium alginate in the designing of sustained drug‐releasing particles for oral delivery is investigated, where calcium alginate‐sago starch particles are prepared via ionic gelation process employing calcium chloride as ionic cross‐linker. These particles showed the aceclofenac loading of 16.94 ± 0.94–18.92 ± 1.17%, aceclofenac encapsulation efficiency of 84.72 ± 1.94–94.59 ± 3.53%, and average particle‐size of 1.11 ± 0.09–1.32 ± 0.11 mm. FESEM analysis indicated spherical‐shaped particles with rough surfaces. FTIR and P‐XRD analyses demonstrated absence of any kinds of interactions in‐between drug‐polymers within particles and the encapsulated aceclofenac present within these polymeric particles is in the amorphous state. All these formulated polymeric particles demonstrated sustained in vitro aceclofenac releasing profile over 12 h and pH‐responsive performance of in vitro swelling. These kinds of sustained drug‐releasing sago starch‐based particles can be advantageous to facilitate reduction of dosing interval and improved oral bioavailability with enhanced patient compliance.

show abstract

Plant Polysaccharides Blended Ionotropically Gelled Alginate Multiple Unit Systems for Sustained Drug Release

Cited by 13 publications

References 131 publications

Characterization of Microwave-Controlled Polyacrylamide Graft Copolymer of Tamarind Seed Polysaccharide

Characterization of Microwave-Controlled Polyacrylamide Graft Copolymer of Tamarind Seed Polysaccharide

Tamarind Seed Polysaccharide: An Emerging Excipient for Pharmaceutical Use

Calcium Alginate‐Sago Starch Particles for Sustained Drug Release: Preparation and In Vitro Characterization

Contact Info

Product

Resources

About