Plant-mediated gold nanoparticles by Dracocephalum kotschyi as anticholinesterase agent: Synthesis, characterization, and evaluation of anticancer and antibacterial activity

Dorosti, Niloufar; Jamshidi, Fatemeh

doi:10.1016/j.jab.2016.03.001

Cited by 92 publications

(42 citation statements)

References 49 publications

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“…As shown in Figures and , the morphology of biosynthesized AuNPs was nearly spherical in shape with small size, which was obtained by TEM and SEM analysis. A similar observation was found that spherical size is smaller than other morphologies . Some large images of biosynthesized AuNPs with triangle, pentagon and hexagon shapes were also observed.…”

Section: Discussionsupporting

confidence: 82%

“…The most important phytochemical constituents present in D. kotschyi leaf extract are reported to contain flavonoids (luteolin‐7‐ O ‐glucoside, apigenin‐7‐ O ‐glucoside (cosmosiin), luteolin 3′‐O‐β‐ d ‐glucuronide, luteolin, apigenin, cirsimaritin, iso‐kaempferide, penduletin, xanthomicrol, calycopterin), a phenolic compound (rosmarinic acid), and protein compounds, which can be responsible for the reduction of Au 3+ ions. Similar results were also reported by many researchers . For instance, previous reports have obtained AuNPs by using plant extracts at a longer incubation period, higher temperature, and greater ratio of plant extract to Au solution.…”

Section: Discussionmentioning

confidence: 99%

“…(2004), Li et al . (2014), and Dorosti and Jamshidi (2016) . The particle size of the biosynthesized AuNPs has been calculated using the Debye–Scherrer equation, D = k λ/β cos θ by determining the width of the (111) peak.…”

Section: Discussionmentioning

confidence: 99%

“…Similar results were also reported by many researchers. [33][34][35][36] For instance, previous reports have obtained AuNPs by using plant extracts at a longer incubation period, higher temperature, and greater ratio of plant extract to Au solution. For example, the incubation time was 5 hr for Nerium oleander leaf extract at 60 C, 37 5 hr for Piper longum fruit extract, 17 60 min for Moringa oleifera petals, 38 and 30 min for Hovenia dulcis fruit extract, 39 at room temperature.…”

Section: Discussionmentioning

confidence: 99%

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Biological applications of phytosynthesized gold nanoparticles using leaf extract of Dracocephalum kotschyi

Chahardoli

Karimi

Fattahi

et al. 2018

J Biomedical Materials Res

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In this work, biosynthesis potentials of Dracocephalum kotschyi leaf extract for the production of gold nanoparticle (AuNPs) were studied, and the biological (catalytic, antibacterial, antioxidant, and anticancer) activities of studied AuNPs were evaluated. Different analytical techniques including UV–visible spectroscopy, X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), energy dispersive X‐ray analysis, and transmission electron microscopy (TEM) were used for the characterization of AuNPs. Moreover, Different testing methods were used for evaluating biological activities of biosynthesized AuNPs. The formation of AuNPs was confirmed by color change and UV–visible spectroscopic analysis. Field emission (FE)‐SEM and TEM images were used to characterize phytosynthesized AuNPs which were predominantly spherical in shape with size in the range of 5–21 nm. These spherical NPs were found to be 39.79 ± 5 nm in size as determined by dynamic light scattering particle size analyzer. XRD pattern confirms the crystalline nature of the biosynthesized nanoparticles. The phytoconstituents involved in the reduction and stabilization of nanoparticles have been identified using FTIR spectra. The phytosynthesized AuNPs showed effective antioxidant, antibacterial and catalytic reduction activities. Furthermore, they have inhibited H1229 and MCF‐7 cancer cell lines proliferation in a dose‐dependent manner. These results have supported that D. kotschyi leaf extract was very efficient for the synthesis of AuNPs, and synthesized NPs showed enhanced biological activities which make them suitable for biomedical applications. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 621–630, 2019.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Biological applications of phytosynthesized gold nanoparticles using leaf extract of Dracocephalum kotschyi

Chahardoli

Karimi

Fattahi

et al. 2018

J Biomedical Materials Res

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“…They also reported that AgNPs had a stronger inhibitory effect on both AChE and BChE than plant leaf extract 79 . Au nanoparticles and D. kotschyi (Labiatae) extract against human AChE and BChE were studied and the results showed that nanoparticles have a stronger anti-cholinesterase activity than those of plant extract 80 . Choon-Sheen Lai et al reported that extract of S. palustris (Burm.)…”

Section: Shikimate-derived Compounds As Ache Inhibitorsmentioning

confidence: 99%

Some Plants as a Source of Acetyl Cholinesterase Inhibitors: A Review

Deka¹,

Kumar²,

Nayak³

et al. 2017

Int. Res. J. Pharm.

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The term dementia derives from the Latin demens ("de" means private, "mens" means mind, intelligence and judgment-"without a mind"). Dementia is a progressive, chronic neurological disorder which destroys brain cells and causes difficulties with memory, behaviour, thinking, calculation, comprehension, language and it is brutal enough to affect work, lifelong hobbies, and social life. Alzheimer's disease, Parkinson's disease, Dementia with Lewys Bodies are some common types of dementias. Acetylcholinesterase AChE) Inhibition, the key enzyme which plays a main role in the breakdown of acetylcholine and it is considered as a Positive strategy for the treatment of neurological disorders. Currently many AChE inhibitors namely tacrine, donepezil, rivastigmine, galantamine have been used as first line drug for the treatment of Alzheimer's disease. They are having several side effects such as gastrointestinal disorder, hepatotoxicity etc, so there is great interest in finding new and better AChE inhibitors from Natural products. Natural products are the remarkable source of Synthetic as well as traditional products. Abundance of plants in nature gives a potential source of AChE inhibitors. The purpose of this article to present a complete literature survey of plants that have been tested for AChE inhibitory activity. Many phytoconstituents and promising plant species as AChE inhibitors are being reported in this communication.

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