Plant Hormone Cytokinins for Modulating Human Aging and Age-Related Diseases

Voller, Jiří; Maková, Barbara; Kadlecová, Alena; González, Gabriel; Strnad, Miroslav

doi:10.1007/978-3-319-63001-4_14

Cited by 16 publications

(4 citation statements)

References 100 publications

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“…The plant hormones cytokinins are predominantly adenine-derived regulatory molecules that take part in almost all stages of plant growth and development. Studies of the biological activity of cytokinins in animal cells, implemented mainly on 6-substituted purines, in particular on kinetin [ 1 , 2 ], have shown the presence of antiviral, antiparasitic, antitumor, antioxidant and other therapeutic properties [ 3 , 4 , 5 , 6 ]. At the same time, many chemical compounds with cytokinin activity other than substituted purines are known, but their activity has not been investigated on animal and human cells.…”

Section: Introductionmentioning

confidence: 99%

Anti-Proliferative and Cytoprotective Activity of Aryl Carbamate and Aryl Urea Derivatives with Alkyl Groups and Chlorine as Substituents

Oshchepkov

Kovalenko²,

Kalistratova³

et al. 2022

Molecules

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Natural cytokinines are a promising group of cytoprotective and anti-tumor agents. In this research, we synthesized a set of aryl carbamate, pyridyl urea, and aryl urea cytokinine analogs with alkyl and chlorine substitutions and tested their antiproliferative activity in MDA-MB-231, A-375, and U-87 MG cell lines, and cytoprotective properties in H2O2 and CoCl2 models. Aryl carbamates with the oxamate moiety were selectively anti-proliferative for the cancer cell lines tested, while the aryl ureas were inactive. In the cytoprotection studies, the same aryl carbamates were able to counteract the CoCl2 cytotoxicity by 3–8%. The possible molecular targets of the aryl carbamates during the anti-proliferative action were the adenosine A2 receptor and CDK2. The obtained results are promising for the development of novel anti-cancer therapeutics.

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Section: Introductionmentioning

confidence: 99%

Anti-Proliferative and Cytoprotective Activity of Aryl Carbamate and Aryl Urea Derivatives with Alkyl Groups and Chlorine as Substituents

Oshchepkov

Kovalenko²,

Kalistratova³

et al. 2022

Molecules

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“…These phytohormones affect antioxidant response, glucose metabolism, cellular processes, cell division, cell cycle regulation, inflammation, cancer, etc. [ 49 , 50 , 51 ].…”

Section: Resultsmentioning

confidence: 99%

Identification and Quantification of Key Phytochemicals, Phytohormones, and Antioxidant Properties in Coccinia grandis during Fruit Ripening

Joo

2022

Antioxidants

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Coccinia grandis contains secondary metabolites, such as flavonoids, phenolic acids, terpenoids, alkaloids, sterols, and glycosides, which are known to have in vitro antioxidant, antidiabetic, anti-inflammatory, and antidyslipidemic activities. C. grandis fruits change dramatically during ripening, and the differences in the phytochemicals contribute to various uses. This study reports the phytochemical compounds and antioxidant activities during ripening of C. grandis for the first time. Characterizations were conducted on the physiologically active substances in C. grandis fruits at three ripening stages, and a total of 25 peaks were identified. Key phytochemicals in the ripening stages of C. grandis were identified, and the major substances that contributed to antioxidant properties were selected and quantitatively analyzed. Although the concentration of tiliroside increased during aging, hydroxycinnamic acid (chlorogenic and p-coumaric acids), flavonols (rutin), and triterpenes (cucurbitacins B and D) with antioxidant effects decreased. Therefore, phenolic compounds and cucurbitacins dominate immature C. grandis quantitatively. Regarding phytohormones, the gibberellin A4 content decreased as the fruits matured, but indoleacetic acid and salicylic acid increased with fruit maturity. The antioxidant capacities determined by DPPH and ABTS consistently decreased with increasing maturity. Accordingly, the extracts of immature C. grandis fruits have high levels of bioactive compounds and can be used to develop food additives and health supplements.

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“…Due to their peculiar effect on cell division and differentiation in plant cells, cytokinins were also studied for their effect on the differentiation of human cells, both normal and malignant (Honma and Ishii 2002). The N 9 -ribosides of CKs (CKRs) showed a higher biological activity, so that became also potential candidates for treating a variety of cancers (Voller et al 2017(Voller et al , 2019.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the radical scavenging activity of some representative isoprenoid and aromatic cytokinin ribosides (N⁶-substituted adenosines) by in vitro chemical assays

Brizzolari¹,

Foti

Saso

et al. 2022

Natural Product Research

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Cytokinins are naturally occurring adenine derivatives whose physiological role is that of growth regulators in plants and that show also many other activities either in plants and in mammalian cells. In plants, they can be found mainly as free bases ((N 6substituted adenines, CKs), but also as the corresponding N 9ribosides (N 6 -substituted adenosines, CKRs). In mammalian cells, CKRs are, in general, more active than CKs. In order to evaluate the intrinsic in vitro antioxidant capacity of some significant CKRs, their scavenging activity against synthetic radicals that are at the basis of well-established antioxidant assays (ORAC, TEAC, DPPH) has been evaluated. The results of the in vitro scavenging activity of biologically relevant radicals such as hydroxyl (HO ), superoxide (O 2 .-) and lipid peroxides (R-OO . ) are reported and discussed.

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Plant Hormone Cytokinins for Modulating Human Aging and Age-Related Diseases

Cited by 16 publications

References 100 publications

Anti-Proliferative and Cytoprotective Activity of Aryl Carbamate and Aryl Urea Derivatives with Alkyl Groups and Chlorine as Substituents

Anti-Proliferative and Cytoprotective Activity of Aryl Carbamate and Aryl Urea Derivatives with Alkyl Groups and Chlorine as Substituents

Identification and Quantification of Key Phytochemicals, Phytohormones, and Antioxidant Properties in Coccinia grandis during Fruit Ripening

Evaluation of the radical scavenging activity of some representative isoprenoid and aromatic cytokinin ribosides (N⁶-substituted adenosines) by in vitro chemical assays

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Plant Hormone Cytokinins for Modulating Human Aging and Age-Related Diseases

Cited by 16 publications

References 100 publications

Anti-Proliferative and Cytoprotective Activity of Aryl Carbamate and Aryl Urea Derivatives with Alkyl Groups and Chlorine as Substituents

Anti-Proliferative and Cytoprotective Activity of Aryl Carbamate and Aryl Urea Derivatives with Alkyl Groups and Chlorine as Substituents

Identification and Quantification of Key Phytochemicals, Phytohormones, and Antioxidant Properties in Coccinia grandis during Fruit Ripening

Evaluation of the radical scavenging activity of some representative isoprenoid and aromatic cytokinin ribosides (N6-substituted adenosines) by in vitro chemical assays

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Evaluation of the radical scavenging activity of some representative isoprenoid and aromatic cytokinin ribosides (N⁶-substituted adenosines) by in vitro chemical assays