The present study aims to explore and document the plant resources used by different communities of Suda and Daijee VDC of Kanchanpur district. A total of 151 plant species belonging to 58 families and 133 genera have been identified and documented. Most of them have medicinal properties in their bark, root, and fruits. A large number of these identified species are used for gastro-intestinal problems, rheumatism, chest infection, cut and wound and in fever. Elderly people and traditional healers of the areas have vast knowledge on ethanomedicinal practices along with various rituals in comparison to the young generation. The knowledge transformation system is quite restricted within family. Mostly exploited plant species like Piper longum, Emblica officinalis, Asparagus racemosus, Terminallia chebula, Terminalia bellirica, Acorus calamus, Azadirchta indica, Cordia vestita, Rauvolfia serpentina, Acacia catechu, Cinnamomum tamala, Zinziber officinalis, and Pterocarpus marsupium are under threat of extinction due to growing human pressure as well as habitat degradation impacted by anthropogenic activities such as grazing, expansion of agriculture land, forest fire, etc.