Plant-Derived Supplementary Carbohydrates, Polysaccharides and Oligosaccharides in Management of Diabetes Mellitus: A Comprehensive Review

Sajadimajd, Soraya; Bahrami, Gholamreza; Daglia, Maria; Nabavi, Seyed Mohammad; Naseri, Rozita; Farzaei, Mohammad Hosein

doi:10.1080/87559129.2019.1584818

Cited by 22 publications

(14 citation statements)

References 119 publications

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“…Plant-derived pharmaceutics are one of the major sources of new drugs for various human diseases including GDM (5,6). Numerous studies have indicated that the incidence rates of certain cancers and coronary heart diseases are the lowest in the Mediterranean basin (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Oleuropein alleviates gestational diabetes mellitus by activating AMPK signaling

Zhang

Zhao

Wang

2021

Endocrine Connections

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Background: Gestational diabetes mellitus (GDM) has a high incidence rate among pregnant women. The objective of the study was to assess the effect of plant-derived oleuropein in attenuating inflammatory and oxidative stress of GDM. Methods: Oleuropein was administered to GDM mice at the doses of 5 or 10 mg/kg/day. Body weight, blood glucose, insulin and hepatic glycogen levels were recorded. To evaluate the effect of oleuropein in reducing oxidative stress, enzyme-linked immunosorbent assay (ELISA) was used to measure the hepatic oxidative stress markers. The inflammation levels of GDM mice were evaluated by measuring serum levels of IL-6 and TNF-α by ELISA, and mRNA levels of IL-1β, TNF-α and IL-6 by real-time PCR (RT-PCR). The AMP-activated protein kinase (AMPK) signaling pathway was assessed by Western blot. Gestational outcome was analyzed through comparing litter size and birth weight. Results: Oleuropein attenuated the elevated body weight of GDM mice, and efficiently reduced blood glucose, insulin and hepatic glycogen levels. Oxidative stress and inflammation were alleviated by oleuropein treatment. The AMPK signaling was activated by oleuropein in GDM mice. Gestational outcome was markedly improved by oleuropein treatment. Conclusions: Our study suggests that oleuropein is effective in alleviating symptoms of GDM and improving gestational outcome in the mouse model. This effect is achieved by attenuating oxidative stress and inflammation, which is mediated by the activation of the AMPK signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Oleuropein alleviates gestational diabetes mellitus by activating AMPK signaling

Zhang

Zhao

Wang

2021

Endocrine Connections

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“…Birhade et al, on the other side, discovered that these differential adsorption processes are deeply influenced by the accessibility of cellulose. When phosphoric acid-swollen cellulose (PASC), ammonia-treated wheat straw (AWS), sodium hydroxide-treated wheat straw (NWS) and nitric acid-treated maize bran (NMB) were used as substrates in pre-enzymatic adsorption step with the following conditions: 20 FPU/g cellulose, pH 4.8, 20 min and 4 • C, 34% (PASC), 27.97% (NWS), 25.11% (NMB) and 8.11% (AWS) of endo-glucanase activity was retained. AWS waste showed a low interaction with β-glucosidase (next to 0.1%), and low endoglucanase retention, which makes this material the best option to selectively remove exo-glucanase activity.…”

Section: Enzyme Name Enzyme Commission Number Activity Productmentioning

confidence: 99%

“…XOS have a recognized potential as prebiotics, being a common ingredient of food complements [9,10]. They are also present in cosmetics, used as gelling agent and for the treatment of diabetes [9,25]. They are also active as immunomodulators and immunostimulators, and their antioxidant activity can be notable too [9].…”

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confidence: 99%

Production of Oligosaccharides from Agrofood Wastes

et al. 2020

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The development of biorefinery processes to platform chemicals for most lignocellulosic substrates, results in side processes to intermediates such as oligosaccharides. Agrofood wastes are most amenable to produce such intermediates, in particular, cellooligo-saccharides (COS), pectooligosaccharides (POS), xylooligosaccharides (XOS) and other less abundant oligomers containing mannose, arabinose, galactose and several sugar acids. These compounds show a remarkable bioactivity as prebiotics, elicitors in plants, food complements, healthy coadyuvants in certain therapies and more. They are medium to high added-value compounds with an increasing impact in the pharmaceutical, nutraceutical, cosmetic and food industries. This review is focused on the main production processes: autohydrolysis, acid and basic catalysis and enzymatic saccharification. Autohydrolysis of food residues at 160-190 • C leads to oligomer yields in the 0.06-0.3 g/g dry solid range, while acid hydrolysis of pectin (80-120 • C) or cellulose (45-180 • C) yields up to 0.7 g/g dry polymer. Enzymatic hydrolysis at 40-50 • C of pure polysaccharides results in 0.06-0.35 g/g dry solid (DS), with values in the range 0.08-0.2 g/g DS for original food residues.Fermentation 2020, 6, 31 2 of 27 forestall engineering approaches, to name a few. Lignocellulosic biomass, of any origin is, therefore, a most promising raw material for biorefineries, considering such facilities as integrated refineries turning biomass into fuels, platform chemicals, food, feed and materials using integrated processes with an optimized used of resources [4]. This vision can be extended to resources of aquatic origin (seaweed, seagrass and microalgae) as well as residues from livestock [5,6]. In general, apart from forestall and energy crops biomass, most of it depends on the production of biomass and, in particular, food wastes [7,8]. While more than 100,000 M tons of biomass wastes are yearly produced [7], wastes strictly considered as food wastes (foods not consumed from any part of the food supply chain or any part of the food that is non edible and, therefore, becomes a residue) account for more than 1300 M tons each year [8]. The valorization of biomass wastes into a plethora of useful energy vectors, chemical compounds and ingredients receives a notable amount of interest from all stakeholders, including researchers and entrepreneurs. They are a source to several value-added products, such as monosaccharides (glucose, xylose, mannose, fructose, arabinose and more), oligosaccharides (fructoor FOS, xylo-or XOS, galacto-or GOS, galacturonic-or GALOS, lactosucrose, etc.), biofuels (ethanol, butanol, dimethylether -DME-, biodiesel, hydrogen), bioactive compounds (flavonoids, phenolic acids, terpenes, terpenoids, carotenoids), nanocellulose (bacterial, wood-related), lignin and its derivatives (a source of aromatics from biomass and prospective substitute of the aromatic or BTEX fraction produced in oil refineries) [8]. Oligomers from cellulose, hemicellulose, lignin, pectin and oth...

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“…Oligosaccharides, a type of low molecular weight carbohydrates, are comprised of 2 to 10 monosaccharides (Singh, Banerjee, Arora, & Fibre, 2015). Enormous bodies of evidence have reported that oligosaccharides isolated from medicinal plants including xylooligosaccharide, isomaltooligosaccharide, fructooligosaccharide, galactooligosaccharide, and sucrose exert a promising anti‐inflammatory, antioxidant as well as hypoglycemic activity (Sajadimajd et al., 2019). Hypoglycemic effects of polysaccharides extracted from Inonotus obliquus and Ophiopogon japonicus were reported in diabetic mice models conducted by modulation of PI3K‐Akt signaling pathway (Wang, Chen, Pan, Gao, & Chen, 2017).…”

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Protective effect of the isolated oligosaccharide from Rosa canina in STZ‐treated cells through modulation of the autophagy pathway

et al. 2020

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Diabetes mellitus (DM) is a metabolic and endocrine disorder that affects millions of people worldwide (Cho et al., 2018). DM is characterized by insulin resistance or progressive pancreatic β-cells devastation accompanied by a disturbance in the metabolism of carbohydrates, lipids, and proteins resulted in a multitude of microand macrovascular complications (Joshi et al., 2019; Luo et al., 2018). The conventional therapeutic options for treatment of DM exhibit insufficient efficacy and can result in several adverse effects including weight gain, hypoglycemia, as well as liver and kidney toxicity. Therefore, discovering new hypoglycemic agents with few side effects and desired potency is necessary to counteract insulin re

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Plant-Derived Supplementary Carbohydrates, Polysaccharides and Oligosaccharides in Management of Diabetes Mellitus: A Comprehensive Review

Cited by 22 publications

References 119 publications

Oleuropein alleviates gestational diabetes mellitus by activating AMPK signaling

Oleuropein alleviates gestational diabetes mellitus by activating AMPK signaling

Production of Oligosaccharides from Agrofood Wastes

Protective effect of the isolated oligosaccharide from Rosa canina in STZ‐treated cells through modulation of the autophagy pathway

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