Plant-Derived Substances with Antibacterial, Antioxidant, and Flavoring Potential to Formulate Oral Health Care Products

Abstract

Bacterial diseases and reactive oxygen species can cause dental caries and oral cancer. Therefore, the present review analyzes and discusses the antibacterial and antioxidant properties of synthetic and plant-derived substances and their current and future patents to formulate dental products. The reviewed evidence indicates that chlorhexidine, fluorides, and hydrogen peroxide have adverse effects on the sensory acceptability of oral care products. As an alternative, plant-derived substances have antimicrobial and antioxidant properties that can be used in their formulation. Also, adding plant metabolites favors the sensory acceptability of dental products compared with synthetic compounds. Therefore, plant-derived substances have antibacterial, antioxidant, and flavoring activity with the potential to be used in the formulation of toothpaste, mouth rinses, dentures cleansers-fixatives, and saliva substitutes.

Oral Mucositis Induced by Chemoradiotherapy in Head and Neck Cancer—A Short Review about the Therapeutic Management and the Benefits of Bee Honey

“…Also some studies in the references are applied on a limited number of patients or are carried out in single study centres. Although reference is made to various types of honey, large studies are needed covering more geographical areas worldwide or to study other specific types of honey (Acacia, Mentha piperita...) considering their recognized properties [59][60][61][62]. In the present context, taking into account the recommendations of studies and international guidelines, the authors support the use of bee honey in the prevention and treatment of OM knowing that this natural agent is easy to administer, effective, highly addressable, inexpensive and easy to purchase, with multiple benefits but especially without side effects.…”

Significance of chlorine‐dioxide‐based oral rinses in preventing SARS‐CoV‐2 cell entry

“…In this regard, developing a unique broad‐spectrum OR, which preferentially targets multiple pathogens in the oral cavity such as herpes simplex virus, human immunodeficiency virus, Candida species including plaque reduction, can be of high demand especially among high‐risk population (Baqui et al, 2001 ; Nicolatou‐Galitis et al, 2001 ). Similarly, the transient usage of such ORs may also have an additional benefit in reducing the potential risk associated with the aspiration pneumonia and/or the associated bloodstream infections (Imai & Tanaka, 2021 ; Lugo‐Flores et al, 2021 ; Ramos et al, 2020 ).…”

“…Moreover, our findings are in line with recent reports suggesting the potential protective role of ORs against SARS‐CoV‐2 (O'Donnell et al, 2020 ). Finally, an innovative and logical aspect in oral care is to prioritize and commercialize plant‐derived ORs (Lugo‐Flores et al, 2021 ) as opposed to be relying entirely on the synthetic products, which have multiple side effects (Bhat et al, 2014 ; Gagari & Kabani, 1995 ; Goldstep, 2014 ). In this direction new formulations can also be developed by infusing ORs with the known natural compounds having potent broad‐spectrum antimicrobial and anti‐inflammatory activities (Tiwari et al, 2009 , 2010 ).…”

Antibacterial activities against Staphylococcus aureus and Escherichia coli of extracted Piper betle leaf materials by disc diffusion assay and batch experiments

“…Adsorption kinetics can be used to explain the mechanism of antibacterial efficiency of PBB. The characteristic constants of sorption were investigated using linear and non-linear models of a pseudo-rst order kinetic model following eqn ( 7) and ( 8) and a pseudo-second order kinetic model following eqn ( 9) and (10), respectively. 45,46 Pseudo-rst order kinetic model: Linear: ln(q e À q t ) ¼ ln q e À k 1 t…”

“…As a result, an alternative of using green plant extractions without metal oxides may be better than nanomaterials and green materials with metal oxides for the antibacterial activities of Gram-positive and Gram-negative bacteria without a dangerous concern to the ecosystem because they are currently applied in many applications of food preservation, skincare products, hair, dental, cosmetics, and biopesticides. 6–11…”