Plant-Derived Polyphenols in Human Health: Biological Activity, Metabolites and Putative Molecular Targets

Olivares-Vicente, Mariló; Barrajón‐Catalán, Enrique; Herranz-López, María; Segura‐Carretero, Antonio; Joven, Jorge; Encinar, José Antonio; Micol, Vicente

doi:10.2174/1389200219666180220095236

Cited by 48 publications

(36 citation statements)

References 167 publications

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“…With regard to the putative metabolites capable of undertaking these effects, previous evidence lead us to propose some phenylpropanoids from L. citriodora and flavonol derivatives from H. sabdariffa. [44][45][46][47] In any case, these hypotheses need to be verified in further animal trials specifically designed for such measurements.…”

Section: Discussion Of Resultsmentioning

confidence: 99%

Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: a randomized controlled trial

et al. 2018

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Based on previous evidence we postulate that AMP-activated protein kinase may have a role in such effects through its capability to modulate energy homeostasis, total daily energy expenditure and lipid management. Although further research may be required, we propose that this polyphenolic combination may be used for weight management by increasing long-term weight loss maintenance through the modulation of appetite biomarkers. This may help to avoid the undesired weight regain typical of calorie restriction diets.

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Section: Discussion Of Resultsmentioning

confidence: 99%

Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: a randomized controlled trial

et al. 2018

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“…In addition, the administration of HS in the form of an extract has also been able to prevent hepatic steatosis by regulating the expression of various genes responsible for glycemic and lipid homeostasis [21], as well as reducing blood pressure and improving vascular endothelial function [11] in hyperlipidemic mouse models [22]. Finally, despite HS being a rich polyphenolic matrix, the scientific literature seems to point to quercetin-3-O-β-D-glucuronide and its aglycone as the main ones responsible for the effects described [23].…”

Section: Weight and Bmimentioning

confidence: 99%

A Randomized, Double-Blind, Placebo Controlled Trial to Determine the Effectiveness a Polyphenolic Extract (Hibiscus sabdariffa and Lippia citriodora) in the Reduction of Body Fat Mass in Healthy Subjects

Marhuenda

Pérez

Victoria-Montesinos

et al. 2020

Foods

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The location and quantity of body fat determine the health risks, limiting people with obesity. Recently, polyphenols have attracted the attention of the scientific community because of their potential use for the reduction of obesity. A proprietary formula comprised of a blend of Lippia citriodora and Hibiscus sabdariffa has been recognized for its high content of polyphenols, powerful antioxidant molecules that may prevent weight gain and could be helpful for the treatment of obesity, as proven previously by in vivo models. The aim of the present study is to determine if the supplementation with Lippia citriodora and Hibiscus sabdariffa is useful for the treatment of obesity and/or weight control in subjects without a controlled diet. The intake of the extract for 84 days reduced body weight, the body mass index, and the fat mass measured with both bioimpedance and densitometry. This decrease in fat mass was observed to a greater extent, being significant, in the fat mass of the trunk (chest and torso).

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“…The major BPs from olive products include phenolic acids and alcohols as well as secoiridoids, while the minor contents are flavonoids and lignans [ 12 ]. The primary olive fruit biophenol secoiridoids (BPsecos) are oleuropein, ligstroside, and their demethylhomologues, which may have potential anticancer effects [ 13 , 14 ]. Olive leaves contain a higher concentration of BPs with secos of 1450 mg/100 FW (fresh weight) compared to the olive fruit and oil, which have 110 mg/100 g and 23 mg/100 mL, respectively [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Olive leaves contain a higher concentration of BPs with secos of 1450 mg/100 FW (fresh weight) compared to the olive fruit and oil, which have 110 mg/100 g and 23 mg/100 mL, respectively [ 9 ]. Oleuropein and ligstroside aglycones, oleacein, oleocanthal, hydroxytyrosil-elenolate, tyrosil-elenolate, oleoside-11-methyl ester, elenoic acid, hydroxytyrosol, and tyrosol are downstream pathway bioactives from oleuropein and ligstroside precursors [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. Oleuropein is the principal BPseco in green olive fruits, leaves, and table olives, whereas olive oil is rich in its downstream metabolites [ 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Probing Downstream Olive Biophenol Secoiridoids

Sivakumar

Uccella

Gentile

2018

IJMS

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Numerous bioactive biophenol secoiridoids (BPsecos) are found in the fruit, leaves, and oil of olives. These BPsecos play important roles in both the taste of food and human health. The main BPseco bioactive from green olive fruits, leaves, and table olives is oleuropein, while olive oil is rich in oleuropein downstream pathway molecules. The aim of this study was to probe olive BPseco downstream molecular pathways that are alike in biological and olive processing systems at different pHs and reaction times. The downstream molecular pathway were analyzed by high performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC-ESI/MS) and typed neglected of different overlap (TNDO) computational methods. Our study showed oleuropein highest occupied molecular orbital (HOMO) and HOMO-1 triggered the free radical processes, while HOMO-2 and lowest unoccupied molecular orbital (LUMO) were polar reactions of glucoside and ester groups. Olive BPsecos were found to be stable under acid and base catalylic experiments. Oleuropein aglycone opened to diales and rearranged to hydroxytyrosil-elenolate under strong reaction conditions. The results suggest that competition among olive BPseco HOMOs could induce glucoside hydrolysis during olive milling due to native olive β-glucosidases. The underlined olive BPsecos downstream molecular mechanism herein could provide new insights into the olive milling process to improve BPseco bioactives in olive oil and table olives, which would enhance both the functional food and the nutraceuticals that are produced from olives.

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Plant-Derived Polyphenols in Human Health: Biological Activity, Metabolites and Putative Molecular Targets

Cited by 48 publications

References 167 publications

Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: a randomized controlled trial

Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: a randomized controlled trial

A Randomized, Double-Blind, Placebo Controlled Trial to Determine the Effectiveness a Polyphenolic Extract (Hibiscus sabdariffa and Lippia citriodora) in the Reduction of Body Fat Mass in Healthy Subjects

Probing Downstream Olive Biophenol Secoiridoids

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