A Randomized, Double-Blind, Placebo Controlled Trial to Determine the Effectiveness a Polyphenolic Extract (Hibiscus sabdariffa and Lippia citriodora) in the Reduction of Body Fat Mass in Healthy Subjects

Abstract

The location and quantity of body fat determine the health risks, limiting people with obesity. Recently, polyphenols have attracted the attention of the scientific community because of their potential use for the reduction of obesity. A proprietary formula comprised of a blend of Lippia citriodora and Hibiscus sabdariffa has been recognized for its high content of polyphenols, powerful antioxidant molecules that may prevent weight gain and could be helpful for the treatment of obesity, as proven previously by in vivo models. The aim of the present study is to determine if the supplementation with Lippia citriodora and Hibiscus sabdariffa is useful for the treatment of obesity and/or weight control in subjects without a controlled diet. The intake of the extract for 84 days reduced body weight, the body mass index, and the fat mass measured with both bioimpedance and densitometry. This decrease in fat mass was observed to a greater extent, being significant, in the fat mass of the trunk (chest and torso).

Hibiscus sabdariffa Linn. Extract Increase Arcuate Nucleus Leptin Receptor mRNA Expression and Promote White Fat Browning

“…At the end of the study, the obese rats are no longer obese. It is consistent with the study by Marhuenda et al (38), Herranz-Lopez et al ( 14), Boix-Castejon et al (39), and Chang et al (40) that showed the administration of H. sabdariffa was able to reduce body weight, body mass index, and fat mass.…”

Effectiveness of a polyphenolic extract (Lippia citriodora and Hibiscus sabdariffa) on appetite regulation in overweight and obese grade I population: an 8-week randomized, double-blind, cross-over, placebo-controlled trial

“…There were also no changes in quality of life test, as well as adverse events in liver or kidney function after product intake [ 74 ]. In this study, researchers found a reduction in fat mass (especially in the torso) after the consumption of 84 days of an Lc-Hs extract in similar population [ 75 ]. In the present study, the BMI of the subjects did not change along the whole study ( p > 0.05).…”

Alternativas Fitoterápicas No Controle Da Obesidade

“…Esse parâmetro da ingestão de líquidos foi associado ao efeito diurético provocado pelo H. sabdariffa (ALARCON-AGUILAR et al, 2007). Marhuenda, J. et al (2020), realizaram um estudo com humanos, avaliando os efeitos do uso concomitante de Lippia citriodora e Hibiscus sabdariffa nos parâmetros relacionados com a obesidade, como peso, o IMC e a massa gorda corporal (MARHUENDA et al, 2020).…”