Abstract:Objective: This study aimed to test the hypothesis that Hibiscus
sabdariffa Linn. Extract (HSE) would increase arcuate nucleus Lep-R,
NPY, and white adipose tissue β3AR mRNA expression in DIO rats. This
study also analyzed the potency of H. sabdariffa bioactive compounds as
an activator of Lep-R and β3AR. Methods: Twenty-four male Sprague-Dawley
rats were separated into four groups: Control (standard chow), DIO
(HFD), DIO-Hib200 (HFD+HSE 200 mg/kg BW), and DIO-Hib400 (HFD+HSE400
mg/kg BW). HSE administration w… Show more
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