Plant-Derived Extracellular Vesicles as Therapeutic Nanocarriers

Karamanidou, Theodora; Tsouknidas, Alexander

doi:10.3390/ijms23010191

Cited by 93 publications

(87 citation statements)

References 40 publications

(129 reference statements)

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“…Recently, growing evidence has suggested possible therapeutic applications for nanoparticles derived from edible plants [ 13 , 14 , 15 ], especially when administered orally to induce immunomodulation. However, their entry pathways and activities are still debated.…”

Section: Plant-derived Evs In Cross-kingdom Delivery—truth or Imagina...mentioning

confidence: 99%

Extracellular Vesicles—Oral Therapeutics of the Future

Cieślik

Nazimek

Bryniarski

2022

IJMS

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Considered an artifact just after discovery, the possibility of oral delivery of extracellular vesicles (EVs) and their functional cargos has recently gained much research attention. EVs from various sources, including edible plants, milk, bacteria and mammalian cells, have emerged as a platform for miRNA and drug delivery that seem to induce the expected immune effects locally and in distant tissues after oral administration. Such a possibility greatly expands the clinical applicability of EVs. The present review summarizes research findings that either support or deny the biological/therapeutical activity of orally administered EVs and their role in cross-species and cross-kingdom signaling.

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Section: Plant-derived Evs In Cross-kingdom Delivery—truth or Imagina...mentioning

confidence: 99%

Extracellular Vesicles—Oral Therapeutics of the Future

Cieślik

Nazimek

Bryniarski

2022

IJMS

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“…(2) EVs-based therapy is another application of EVs in medicine. As mentioned above, many researchers have shown that EVs from various plants have anticancer or regenerative properties [ 127 , 128 ]. For example, EVs from different plants are cytotoxic and anti-proliferative for many tumor cells [ 44 ].…”

Section: Advantages and Challengesmentioning

confidence: 99%

Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges

et al. 2022

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Background Many eukaryote cells produce membrane-enclosed extracellular vesicles (EVs) to establish cell-to-cell communication. Plant-derived EVs (P-EVs) contain proteins, RNAs, lipids, and other metabolites that can be isolated from the juice, the flesh, and roots of many species. Methods In the present review study, we studied numerous articles over the past two decades published on the role of P-EVs in plant physiology as well as on the application of these vesicles in different diseases. Results Different types of EVs have been identified in plants that have multiple functions including reorganization of cell structure, development, facilitating crosstalk between plants and fungi, plant immunity, defense against pathogens. Purified from several edible species, these EVs are more biocompatible, biodegradable, and extremely available from many plants, making them useful for cell-free therapy. Emerging evidence of clinical and preclinical studies suggest that P-EVs have numerous benefits over conventional synthetic carriers, opening novel frontiers for the novel drug-delivery system. Exciting new opportunities, including designing drug-loaded P-EVs to improve the drug-delivery systems, are already being examined, however clinical translation of P-EVs-based therapies faces challenges. Conclusion P-EVs hold great promise for clinical application in the treatment of different diseases. In addition, despite enthusiastic results, further scrutiny should focus on unravelling the detailed mechanism behind P-EVs biogenesis and trafficking as well as their therapeutic applications.

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“…Plant-derived exosome-like nanoparticles (ELNs) have been shown to also prevent and treat a variety of diseases, with functions closely related to the plant of origin ( Teng et al, 2018 ; Cong et al, 2022 ). ELNs have lipid membrane structures that can also be used as natural or engineered carriers for drug loading and delivery ( Karamanidou & Tsouknidas, 2021 ). Moreover, ELNs are cost-effective and easy to obtain, and have great potential for development and application.…”

Section: Exosomes As Targets For the Treatment Of Cardiac Fibrosismentioning

confidence: 99%

Diagnostic and Therapeutic Properties of Exosomes in Cardiac Fibrosis

Fan

Ren²,

2022

Front. Cell Dev. Biol.

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Cardiac fibrosis results from both the differentiation of cardiac fibroblasts and excessive accumulation of extracellular matrix (ECM), leading to myocardial stiffness and reduced compliance of the ventricular wall. The conversion of cardiac fibroblasts to myofibroblasts is the most important initiating step in the process of this pathological cardiac remodeling. It occurs during the progression of many cardiovascular diseases, adversely influencing both the clinical course and outcome of the disease. The pathogenesis is complex and there is no effective treatment. Exosomes are extracellular vesicles that mediate intercellular communication through delivering specific cargoes of functional nucleic acids and proteins derived from particular cell types. Recent studies have found that exosomes play an important role in the diagnosis and treatment of cardiac fibrosis, and is a potential biotherapeutics and drug delivery vectors for the treatment of cardiac fibrosis. The present review aimed to summarize the current knowledge of exosome-related mechanisms underlying cardiac fibrosis and to suggest potential therapy that could be used to treat the condition.

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Plant-Derived Extracellular Vesicles as Therapeutic Nanocarriers

Cited by 93 publications

References 40 publications

Extracellular Vesicles—Oral Therapeutics of the Future

Extracellular Vesicles—Oral Therapeutics of the Future

Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges

Diagnostic and Therapeutic Properties of Exosomes in Cardiac Fibrosis

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