Plant-Derived Chinese Medicine Monomers on Ovarian Cancer via the Wnt/β-Catenin Signaling Pathway: Review of Mechanisms and Prospects

Xu, Jiayue; Liu, Fang-Yuan; Liu, Shaoxuan; Xie, Liangzhen; Li, Jia; Ma, Yuting; Han, Feng-Juan

doi:10.1155/2021/6852867

Cited by 9 publications

(6 citation statements)

References 83 publications

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“…We therefore considered that the molecular mechanism of ACY1-regulated cetuximab resistance in CRC was related to the Wnt signaling pathway. As expected, our results revealed that the expression of β-catenin, a key protein in the Wnt/β-catenin pathway, was significantly decreased with increasing radiation dose, while the levels of E-cadherin, a downstream protein in the Wnt/β-catenin pathway and a marker of tumor migration [ 52 , 53 ], were significantly increased. Finally, we found that the levels of E-cadherin were further increased, and the levels of β-catenin were further decreased in ACY1-downregulated HCT116-R cells after irradiation.…”

Section: Discussionsupporting

confidence: 82%

ACY1 Downregulation Enhances the Radiosensitivity of Cetuximab-Resistant Colorectal Cancer by Inactivating the Wnt/β-Catenin Signaling Pathway

Shan

Dai

Zhang

et al. 2022

Cancers

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Treatment of cetuximab-resistant colorectal cancer (CRC) is a global healthcare problem. This study aimed to assess the effects of radiotherapy on cetuximab-resistant CRC and explore the underlying mechanism. We established a cetuximab-resistant HCT116 cell line (HCT116-R) by extracorporeal shock. Differentially expressed mRNAs were screened from cells treated with different radiation doses using second-generation high-throughput sequencing. Sequence data showed that ACY1 was significantly downregulated in HCT116-R cells after irradiation. Analysis of the GEO and TCGA datasets revealed that high ACY1 expression was associated with lymph node metastasis and a poor prognosis in CRC patients. In addition, immunohistochemistry results from CRC patients revealed that ACY1 protein expression was related to cetuximab resistance and lymph node metastasis. These findings suggested that ACY1 may function as an oncogene to promote CRC progression and regulate the radiosensitivity of cetuximab-resistant CRC. As expected, ACY1 silencing weakened the proliferation, migration, and invasion abilities of HCT116-R cells after radiotherapy. Mechanistically, TCGA data demonstrated that ACY1 expression was closely related to the Wnt/β-catenin pathway in CRC. We validated that radiotherapy first reduced β-catenin levels, followed by decreased expression of the metastasis-related protein E-cadherin. Silencing ACY1 dramatically enhanced these changes in β-catenin and E-cadherin after radiotherapy. In conclusion, ACY1 downregulation could enhance the radiosensitivity of cetuximab-resistant CRC by inactivating Wnt/β-catenin signaling, implying that ACY1 may serve as a radiotherapy target for cetuximab-resistant CRC.

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Section: Discussionsupporting

confidence: 82%

ACY1 Downregulation Enhances the Radiosensitivity of Cetuximab-Resistant Colorectal Cancer by Inactivating the Wnt/β-Catenin Signaling Pathway

Shan

Dai

Zhang

et al. 2022

Cancers

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“…Along with safety concerns, it is also difficult to meet clinical needs [ 19 – 21 ]. Pilot studies have shown that TCM, including MAP 30 and Paclitaxel, has been extensively applied to treat ovarian cancer effectively [ 8 – 10 , 14 ]. However, despite extensive clinical research, the clinical efficacy of TCM is still not well understood.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence-Based Complementary and Alternative Medicine [8][9][10]14]. However, despite extensive clinical research, the clinical efficacy of TCM is still not well understood.…”

Section: Discussionmentioning

confidence: 99%

“…If not appropriately diagnosed early, ovarian cancer can be life-threatening and more challenging to treat at later stages [ 4 , 6 ]. Previously, traditional Chinese medicine (TCM) has been extensively applied as a promising adjunctive drug in the fight against ovarian cancer [ 7 , 8 ]. For instance, bitter lemon seeds-derived MAP 30 [ 9 ] and yew-derived Paclitaxel [ 10 ] have recently achieved safe and curative effects against ovarian cancers.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Laparoscopic Hyperthermic Perfusion Therapy Combined with Adjuvant Treatment of Compound Yew Capsule on Ovarian Blood Flow Parameters and Immune Function in Patients with Ovarian Cancer

Wang

Huang

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To determine the effects of laparoscopic hyperthermic perfusion therapy combined with adjuvant compound yew capsules on ovarian blood flow parameters and immune function in patients with ovarian cancer (OC). Methods. A total of 90 OC patients enrolled in our hospital between January 2019 and January 2020 were randomly distributed into the control (Con group) and experimental group (Exp group) based on the sealed envelope method. The Con group was administered laparoscopic hyperthermic perfusion therapy. On this basis, the Exp group was subjected to compound yew capsules; the ovarian blood flow parameters and immune function indexes were compared between the two groups. Results. The Exp group was reported to perform better than the Con group regarding ovarian blood flow parameters and immune indexes after treatment ( p < 0.001 ). Conclusion. Laparoscopic hyperthermic perfusion therapy combined with adjuvant compound yew capsules for patients with OC can substantially improve the clinical indexes and immune function. Furthermore, research and adequate promotion are needed to elicit the evidence beyond preclinical studies to understand the intricacies of its implementation.

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“…Traditional Chinese medicine has a multi-target, multi-pathway compound effect and its monomer preparations are characterized by small side effects and significant therapeutic effects ( 8 ). Such features allow the treatment of ischemic stroke by traditional Chinese medicine to have great potential for its application in a wide range of diseases.…”

Section: Introductionmentioning

confidence: 99%

Alcohol extract of Rubia yunnanensis: Metabolic alterations and preventive effects against OGD/R‑induced oxidative damage in HT22 cells

Cheng,

Li,

Yang

et al. 2024

Biomed Rep

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The present study investigated the inhibitory and neuroprotective effects of Rubia yunnanensis alcohol extract (RY-A) on oxidative stress induced by oxygen-glucose deprivation/reoxygenation (OGD/R) in HT22 cells. In vitro cultured HT22 cells were randomly divided into control, OGD/R, OGD/R + 100 µmol/l edaravone and OGD/R + 10, 20 and 40 µg/ml RY-A groups. Oxygen-sugar deprivation was performed with 10 mmol/l sodium dithionite combined with sugar-free DMEM medium for 2 h, followed by re-glycolization and reoxygenation for 2 h to establish an in vitro OGD/R model. Cell morphology was observed under a phase contrast microscope. Cell survival rate was detected by thiazolyl blue and lactate dehydrogenase and oxidative stress-related indexes were detected by commercial kits. The effects and metabolic alterations of RY-A treatment after OGD/R were evaluated using ultra-high performance liquid chromatography and mass spectrometry. Protein levels were further examined by western blotting. The results showed that cells in the OGD/R group were swollen and lacked protrusions, had significantly reduced viability and had significantly elevated oxidative stress-related indexes of reactive oxygen species, nitric oxide levels and malondialdehyde content and significantly reduced activities of the antioxidant enzymes superoxide dismutase and glutathione peroxidase, compared with controls. Compared with the OGD/R group, the RY-A group had significantly improved cell morphology and significantly increased cell viability and in terms of oxidative stress, exhibited significantly reduced reactive oxygen species, nitric oxide levels and malondialdehyde content, as well as significantly increased superoxide dismutase and glutathione peroxidase activities. Metabolomic analysis identified changes in 20 metabolites, including L-tryptophan, ornithine, eicosapentaenoic acid-d5, isosafrole and xanthine. Metabolomics analysis showed that the pathways affected included those related to phenylalanine, tyrosine and tryptophan biosynthesis, the prolactin signaling pathway and amphetamine addiction. These results suggested that RY-A had significant preventive effects on an in vitro model of cerebral ischemia-reperfusion injury simulated by OGD/R and the mechanism may be related to increased tryptophan content, activation of indoleamine 2,3-dioxygenase enzymes and inhibition of oxidative stress.

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Plant-Derived Chinese Medicine Monomers on Ovarian Cancer via the Wnt/β-Catenin Signaling Pathway: Review of Mechanisms and Prospects

Cited by 9 publications

References 83 publications

ACY1 Downregulation Enhances the Radiosensitivity of Cetuximab-Resistant Colorectal Cancer by Inactivating the Wnt/β-Catenin Signaling Pathway

ACY1 Downregulation Enhances the Radiosensitivity of Cetuximab-Resistant Colorectal Cancer by Inactivating the Wnt/β-Catenin Signaling Pathway

Effects of Laparoscopic Hyperthermic Perfusion Therapy Combined with Adjuvant Treatment of Compound Yew Capsule on Ovarian Blood Flow Parameters and Immune Function in Patients with Ovarian Cancer

Alcohol extract of Rubia yunnanensis: Metabolic alterations and preventive effects against OGD/R‑induced oxidative damage in HT22 cells

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