Plant cell cultures: An enzymatic tool for polyphenolic and flavonoid transformations

Mohamed, Tarik A.; Ali, Sherin K.; Elshamy, Abdelsamed I.; Saleh, İbrahim; Atia, Mohamed A. M.; Alshammari, Shifaa O.; Mohamed, Abou El‐Hamd H.; Hussien, Taha A.; Hamed, Ahmed R.; El-Seedi, Hesham R.; Abdel-Azim, Nahla S.; Shams, Khaled A.; Efferth, Thomas; Sakr, Mohamed; Paré, Paul W.; Hegazy, Mohamed‐Elamir F.

doi:10.1016/j.phymed.2022.154019

Cited by 4 publications

(1 citation statement)

References 57 publications

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“…Different biotransformation reactions can be achieved by A. niger, including hydroxylation, hydrogenation, epoxidation, hydrolysis, reduction, cyclization and alkylation, depending on the starting materials and the reaction conditions ( Figure 14B ). ( Mohamed et al, 2022 ). Through the Sequence-Structure-Function-Evolution (SSFE) strategy the research group of Meinert and coworkers discovered 66 novel bacterial chalcone isomerase enzymes (CHIs) using the GenBank database.…”

Section: Biocatalysismentioning

confidence: 99%

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

Marotta

Rossi²,

Ibba³

et al. 2022

Front. Chem.

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The sustainable use of resources is essential in all production areas, including pharmaceuticals. However, the aspect of sustainability needs to be taken into consideration not only in the production phase, but during the whole medicinal chemistry drug discovery trajectory. The continuous progress in the fields of green chemistry and the use of artificial intelligence are contributing to the speed and effectiveness of a more sustainable drug discovery pipeline. In this light, here we review the most recent sustainable and green synthetic approaches used for the preparation and derivatization of chalcones, an important class of privileged structures and building blocks used for the preparation of new biologically active compounds with a broad spectrum of potential therapeutic applications. The literature here reported has been retrieved from the SciFinder database using the term “chalcone” as a keyword and filtering the results applying the concept: “green chemistry”, and from the Reaxys database using the keywords “chalcone” and “green”. For both databases the time-frame was 2017–2022. References were manually selected based on relevance.

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Section: Biocatalysismentioning

confidence: 99%

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

Marotta

Rossi²,

Ibba³

et al. 2022

Front. Chem.

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Micropropagation and GC–MS analysis of bioactive compounds in bulbs and callus of white squill

El-Naggar

Shehata

Morsi

2023

In Vitro Cell.Dev.Biol.-Plant

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Medicinal herbs are the main source of bioactive compounds used in the medical industry. White squill (Urginea maritima) is an important medicinal and ornamental plant cultivated in the Mediterranean region. This study reports an efficient protocol for in vitro propagation of Urginea and investigates important bioactive compounds present in the bulbs and in vitro–produced callus. The least number of days for callus induction and shoot regeneration was achieved with Murashige and Skoog (MS) basal media supplemented with 1.0 mg L−1 1-naphthaleneacetic acid (NAA) plus 0.1 mg L−1 6-benzylaminopurine (BAP) and 1.0 mg L−1 NAA plus 0.4 mg L−1 BAP, respectively, while the highest number of shoots and fresh weight were obtained at medium supplemented with 1.0 mg L−1 NAA plus 0.5 mg L−1 BAP. Gas chromatography-mass spectrometry (GC–MS) analysis of Urginea bulb methanol extract showed the existence of important secondary metabolites, such as palmitic acid (C16H32O2), 9-hexadecenoic acid (C16H30O2), phthalic acid 2-ethylhexyl propyl ester (C19H28O4), tetradecanoic acid (C14H28O2), undecanoic acid (C11H22O2), and oleic acid (C18H34O2), in addition to other important compounds, such as 13-heptadecyn-1-ol, 9,12-octadecadienoic acid, 1-monolinoleoylglycerol trimethylsilyl ether, 2-methyl-1-hexadecanol, and octadecanoic acid. Callus methanol extracts showed a reduction in the percentages of most phyto-components compared to bulb extract except for oleic acid, 3-(octadecyloxy) propyl ester and 3-hydroxydodecanoic acid; on the other hand, some important compounds were detected only in callus extract possessing anti-cancer, antiviral, and anti-inflammatory effects, such as farnesol (C15H26O), 7-methyl-Z-tetradecen-1-ol acetate (C17H32O2), ethyl iso-allocholate (C26H44O5), 4-trifluoroacetoxypentadecane (C17H31F3O2), and 2-hydroxyhexadecanoic acid (C16H32O3).

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Molecular mechanism for the interaction of natural products with ionic liquids: Insights from MD and DFT study

Zheng,

Jiang,

Zheng

et al. 2024

Journal of Molecular Liquids

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Plant cell cultures: An enzymatic tool for polyphenolic and flavonoid transformations

Cited by 4 publications

References 57 publications

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

Micropropagation and GC–MS analysis of bioactive compounds in bulbs and callus of white squill

Molecular mechanism for the interaction of natural products with ionic liquids: Insights from MD and DFT study

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