Plant based food bioactives: A boon or bane for neurological disorders

Choudhary, Neeraj; Tewari, Devesh; Nabavi, Seyed Fazel; Kashani, Hamid Reza Khayat; Lorigooini, Zahra; Filosa, Rosanna; Badrealam, Khan Farheen; Masoudian, Nooshin; Nabavi, Seyed Mohammad

doi:10.1080/10408398.2022.2131729

Cited by 3 publications

(1 citation statement)

References 446 publications

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“…Researchers believe these effects to be mediated by an increase in caspase-3 expression [238]. Luteolin Luteolin (Figure 5) is a flavone present in several vegetables and fruits and is reported to have several therapeutic activities, such as antioxidant, antimicrobial, anticancer, neuroprotective, antiviral, cardioprotective, and anti-inflammatory properties [349,350]. Luteolin has been observed to promote apoptosis in A549 cells at a concentration of 20-80 µM.…”

Section: Isorhamnetinmentioning

confidence: 99%

Targeting Cell Signaling Pathways in Lung Cancer by Bioactive Phytocompounds

Choudhary

Bawari

Burcher

et al. 2023

Cancers

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Lung cancer is a heterogeneous group of malignancies with high incidence worldwide. It is the most frequently occurring cancer in men and the second most common in women. Due to its frequent diagnosis and variable response to treatment, lung cancer was reported as the top cause of cancer-related deaths worldwide in 2020. Many aberrant signaling cascades are implicated in the pathogenesis of lung cancer, including those involved in apoptosis (B cell lymphoma protein, Bcl-2-associated X protein, first apoptosis signal ligand), growth inhibition (tumor suppressor protein or gene and serine/threonine kinase 11), and growth promotion (epidermal growth factor receptor/proto-oncogenes/phosphatidylinositol-3 kinase). Accordingly, these pathways and their signaling molecules have become promising targets for chemopreventive and chemotherapeutic agents. Recent research provides compelling evidence for the use of plant-based compounds, known collectively as phytochemicals, as anticancer agents. This review discusses major contributing signaling pathways involved in the pathophysiology of lung cancer, as well as currently available treatments and prospective drug candidates. The anticancer potential of naturally occurring bioactive compounds in the context of lung cancer is also discussed, with critical analysis of their mechanistic actions presented by preclinical and clinical studies.

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Section: Isorhamnetinmentioning

confidence: 99%

Targeting Cell Signaling Pathways in Lung Cancer by Bioactive Phytocompounds

Choudhary

Bawari

Burcher

et al. 2023

Cancers

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Potential role of hesperidin in lifestyle disorders: A scoping review

Tayal,

Munjal,

Gauttam

et al. 2023

South African Journal of Botany

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Multifaceted Pharmacological Potentials of Curcumin, Genistein, and Tanshinone IIA through Proteomic Approaches: An In-Depth Review

Khan

Singh

Jamous

et al. 2022

Cancers

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Phytochemicals possess various intriguing pharmacological properties against diverse pathological conditions. Extensive studies are on-going to understand the structural/functional properties of phytochemicals as well as the molecular mechanisms of their therapeutic function against various disease conditions. Phytochemicals such as curcumin (Cur), genistein (Gen), and tanshinone-IIA (Tan IIA) have multifaceted therapeutic potentials and various efforts are in progress to understand the molecular dynamics of their function with different tools and technologies. Cur is an active lipophilic polyphenol with pleiotropic function, and it has been shown to possess various intriguing properties including antioxidant, anti-inflammatory, anti-microbial, anticancer, and anti-genotoxic properties besides others beneficial properties. Similarly, Gen (an isoflavone) exhibits a wide range of vital functions including antioxidant, anti-inflammatory, pro-apoptotic, anti-proliferative, anti-angiogenic activities etc. In addition, Tan IIA, a lipophilic compound, possesses antioxidant, anti-angiogenic, anti-inflammatory, anticancer activities, and so on. Over the last few decades, the field of proteomics has garnered great momentum mainly attributed to the recent advancement in mass spectrometry (MS) techniques. It is envisaged that the proteomics technology has considerably contributed to the biomedical research endeavors lately. Interestingly, they have also been explored as a reliable approach to understand the molecular intricacies related to phytochemical-based therapeutic interventions. The present review provides an overview of the proteomics studies performed to unravel the underlying molecular intricacies of various phytochemicals such as Cur, Gen, and Tan IIA. This in-depth study will help the researchers in better understanding of the pharmacological potential of the phytochemicals at the proteomics level. Certainly, this review will be highly instrumental in catalyzing the translational shift from phytochemical-based biomedical research to clinical practice in the near future.

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Plant based food bioactives: A boon or bane for neurological disorders

Cited by 3 publications

References 446 publications

Targeting Cell Signaling Pathways in Lung Cancer by Bioactive Phytocompounds

Targeting Cell Signaling Pathways in Lung Cancer by Bioactive Phytocompounds

Potential role of hesperidin in lifestyle disorders: A scoping review

Multifaceted Pharmacological Potentials of Curcumin, Genistein, and Tanshinone IIA through Proteomic Approaches: An In-Depth Review

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