Plant-based anticancer molecules: A chemical and biological profile of some important leads

Srivastava, Vandana; Negi, Arvind S.; Kumar, Jonnala Kotesh; Gupta, Madan M.; Khanuja, S. P. S.

doi:10.1016/j.bmc.2005.05.066

Cited by 324 publications

(148 citation statements)

References 79 publications

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“…This important class of natural products has drawn much attention since the discovery of the aryltetralin lignan podophyllotoxin, the establishment of its potent cytotoxic effects and the eventual successful commercialization of its semisynthetic derivatives, namely etoposide, teniposide and the pro-drug etopophos [2][3][4]. The latter drugs comprise an important class of antineoplastic agents used for the treatment of diverse malignancies, such as Hodgkin's disease, small cell lung cancer, testicular cancer etc [4][5][6][7][8].…”

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confidence: 99%

Effect of justicidin B – a potent cytotoxic and pro-apoptotic arylnaphtalene lignan on human breast cancer-derived cell lines

Momekov¹,

Konstantinov²,

Dineva³

et al. 2011

neo

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Justicidin B produced by genetically transformed cultures of Linum leonii was tested for cytotoxic activity and induction of apoptosis in MDA-MB-231 and MCF-7 breast cancer derived cell lines. The tested lignan evoked strong, concentration dependent cytotoxicity in both cell lines, whereby MCF-7 proved to be far more sensitive as compared to MDA-MB-231. The 24 h treatment of both cell lines increased the level of apoptotic DNA fragmentation; however the proapoptotic activity is completely inhibited if the cells are co-incubated with the non-selective pan-caspase inhibitor Boc-Asp(OMe)-fluoromethyl ketone (PCI), which implies that justicidin B, activates programmed cell death via caspase -dependent mechanisms. Exposure of MDA-MB-231 cells with justicidin B leads to concentration dependent decrease in the expression of NFkB; whereas the treatment of MCF-7, is consistent with strong increase in the expression of this transcription factor.

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confidence: 99%

Effect of justicidin B – a potent cytotoxic and pro-apoptotic arylnaphtalene lignan on human breast cancer-derived cell lines

Momekov¹,

Konstantinov²,

Dineva³

et al. 2011

neo

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“…It is important to mention that various antitumor drugs currently used, such as paclitaxel from the vinca alkaloids and camptothecin were isolated from medicinal plants, which makes plant bioprospecting an important resource to be exploited in the search for new therapeutic approaches against cancer (Srivastava et al, 2005). Thus, the results with H. stigonocarpa evidenced here suggest the need for studies with cancer cell lines and in vivo tests in rodents under different exposure times and different treatment regimens, to thus establish with propriety, the real cytotoxic and antimutagenic potential of this legume.…”

Section: Concentrationmentioning

confidence: 99%

Antimitotic and antimutagenic action of the Hymenaea stigonocarpa bark on dividing cells

et al. 2016

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The objective of this study was to evaluate the action of Hymenaea stigonocarpa bark hydroalcoholic extract against a mutagenic compound using A. cepa meristematic root cells as a test system. The treatment groups were: Negative Control (NC) -distilled water; Positive Control (PC) -paracetamol at a concentration of 0.008 mg/mL, Jatoba Control (JC) -aqueous fraction jatobá-do-cerrado at 0.5 or 1.0 or 1.5 mg/mL, and Simultaneous Treatment (ST) -jatobá-do-cerrado aqueous fraction at a concentration of 0.5 or 1.0 or 1.5 mg/mL associated with paracetamol solution at a concentration of 0.008 mg/mL. All groups were analyzed at 24 and 48 h. Five onion bulbs (five replications) were used for each treatment group. The root tips were fixed in Carnoy and slides prepared by the crush technique. Cells were analyzed throughout the cell cycle, totaling 5,000 for each treatment group at each exposure time. Mitotic indices were subjected to statistical analysis using the chi-square test (p<0.05). From the results it was found that the ST group, at the three concentrations, significantly potentiated the antiproliferative effect of the test system cells when compared to PC, NC and TJ at the three concentrations. Furthermore, the three ST concentrations significantly reduced the number of cell aberrations when compared to the number of aberrant cells obtained for the PC, demonstrating antimutagenic action on the A. cepa test system cells.Keywords: jatobá-do-cerrado, cytotoxicity, protector effect. Ação antimitótica e antimutagênica do ritidoma de Hymenaea stigonocarpa Mart ex Hayne na divisão celularResumo O objetivo do presente trabalho foi avaliar a ação do extrato hidroalcólico do ritidoma de Hymenaea stigonocarpa frente a um composto mutagênico, utilizando como sistema teste as células meristemáticas de raízes de A. cepa. Os grupos tratamentos avaliados foram: Controle Negativo (CN) -água destilada; Controle Positivo (CP) -paracetamol na concentração de 0,008 mg/mL, Controle Jatobá (CJ) -fração aquosa de jatobá-do-cerrado na concentração de 0,5 ou 1,0 ou 1,5 mg/mL, e Tratamento Simultâneo (TS) -fração aquosa de jatobá-do-cerrado na concentração de 0,5 ou 1,0 ou 1,5 mg/mL associada a solução de paracetamol na concentração de 0,008 mg/mL. Todos os grupos foram analisados nos tempos de 24 e 48 h. Para cada grupo tratamento cinco bulbos de cebolas (cinco repetições) foram utilizados. As radículas foram fixadas em Carnoy e as lâminas preparadas pela técnica de esmagamento. Analisaram-se células em todo ciclo celular, totalizando 5.000 para cada grupo tratamento em cada tempo de exposição. Os índices mitóticos obtidos foram submetidos à análise estatística do 05). A partir dos resultados verificou-se que o grupo TS, nas três concentrações, potencializou o efeito antiproliferativo significativo as células do sistema teste quando comparado ao CP, CN e TJ nas três concentrações. Ainda, o TS nas três concentrações reduziu de forma significativa o número de aberrações celulares quando comparado com o número de células aberrantes ob...

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“…Many existing drugs are derived from plants, such as camptothecin, vincristine, vinblastine, taxol, podophyllotoxin, and combretastatin, among others. 12 Despite a large number of existing anticancer drugs of natural origin, the pharmacological potential of many plant species has not yet been fully explored. The Erythroxylaceae family comprises 4 genera containing a total of 240 different species that are found endemically in countries such as Venezuela, Brazil, and Madagascar.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic effect ofErythroxylum daphnitesextract is associated with G₁cell cycle arrest and apoptosis in oral squamous cell carcinoma

et al. 2016

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Plant-derived molecules showing antineoplastic effects have recently gained increased attention as potential adjuvants to traditional therapies for various cancers. Cerrado biome in Brazil contains high floral biodiversity, but knowledge about the potential therapeutic effects of compounds derived from that flora is still limited. The present study investigated the antineoplastic activity of Erythroxylum daphnites Mart., a Brazilian native plant from Cerrado biome, in the SCC-9 oral squamous cell carcinoma cell line. Cells were treated with various concentrations of hexane extract of Erythroxylum daphnites leaves (EDH) and assessed for cytotoxicity, proliferation, and apoptosis. Thin layer chromatography was conducted to characterize the substances present in EDH. Our results showed that EDH exerted anti-proliferative effects in SCC-9 cells by stabilizing the cell cycle at G 1 phase in association with reduced intracellular levels of cyclins D and E and increased level of p21. EDH also demonstrated pro-apoptotic properties, as shown by an increased expression of caspase-3. Triterpenes were the major constituents of EDH. Our findings demonstrated a cytotoxic effect of EDH against SCC-9 cells in vitro mediated by the restraint of cellular proliferation and induction of apoptosis. Taken together, these findings support EDH constituents as potential therapeutic adjuvants for oral cancer.

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Plant-based anticancer molecules: A chemical and biological profile of some important leads

Cited by 324 publications

References 79 publications

Effect of justicidin B – a potent cytotoxic and pro-apoptotic arylnaphtalene lignan on human breast cancer-derived cell lines

Effect of justicidin B – a potent cytotoxic and pro-apoptotic arylnaphtalene lignan on human breast cancer-derived cell lines

Antimitotic and antimutagenic action of the Hymenaea stigonocarpa bark on dividing cells

Cytotoxic effect ofErythroxylum daphnitesextract is associated with G₁cell cycle arrest and apoptosis in oral squamous cell carcinoma

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Plant-based anticancer molecules: A chemical and biological profile of some important leads

Cited by 324 publications

References 79 publications

Effect of justicidin B – a potent cytotoxic and pro-apoptotic arylnaphtalene lignan on human breast cancer-derived cell lines

Effect of justicidin B – a potent cytotoxic and pro-apoptotic arylnaphtalene lignan on human breast cancer-derived cell lines

Antimitotic and antimutagenic action of the Hymenaea stigonocarpa bark on dividing cells

Cytotoxic effect ofErythroxylum daphnitesextract is associated with G1cell cycle arrest and apoptosis in oral squamous cell carcinoma

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Cytotoxic effect ofErythroxylum daphnitesextract is associated with G₁cell cycle arrest and apoptosis in oral squamous cell carcinoma