Plant as a Source of Natural Antiviral Agents

Sohail, Muhammad Nouman; Rasul, Fiaz; Karim, Asia; Kanwal, Uzma; Attitalla, Idress Hamad

doi:10.3923/ajava.2011.1125.1152

Cited by 54 publications

(20 citation statements)

References 122 publications

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“…6 Natural products have been viable and sustainable source of antimicrobial agents in the past and several natural compounds are reported to have antiviral properties. 5,[7][8][9] Recently we have shown the efficacy of neem and tulsi based natural compounds against the key SARS-CoV-2 targets. 10 Tinospora cordifolia (TC), a deciduous, extensively-spreading, climbing her baceous vine of the family Menispermaceae is considered an essential herbal plant in the Indian system of medicine.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Natural Compounds from Tinospora cordifolia Against SARS-CoV-2 Protease, Surface Glycoprotein and RNA Polymerase

Sagar¹,

Kumar

2020

BEMS Reports

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Background: Antiviral activity of natural compounds from Tinospora cordifolia (Amritaballi) were evaluated for their efficacy against SARS-CoV-2 targets involved in virus attachment and replication. Materials and Methods: The binding efficacy (binding affinity, K i and IC 50 values) of natural compounds from Tinospora cordifolia were tested using in silco tools against four key SARS-CoV-2 targets i.e., 1) surface glycoprotein (6VSB) and 2) Receptor binding domain (6M0J) both responsible for attachment of the virus to host cell, 3)RNA dependent RNA polymerase (6M71) and 4) main protease (6Y84) responsible for replication of the virus in the host cell. Results: Berberine, Isocolumbin, Magnoflorine and Tinocordiside showed high binding efficacy against all the four key SARS-CoV-2 targets. Tinocordiside and Isocolumbin showed IC 50 value of < 1µM against both 6Y84 and 6VSB. Conclusion: At least four natural compounds from Tinospora cordifolia showed high binding efficacy against SARS-CoV-2 targets involved in attachment and replication of the virus. Hence validating the merit of using Tinospora cordifolia in the clinical management of infection caused by SARS-CoV-2.

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Section: Introductionmentioning

confidence: 99%

Efficacy of Natural Compounds from Tinospora cordifolia Against SARS-CoV-2 Protease, Surface Glycoprotein and RNA Polymerase

Sagar¹,

Kumar

2020

BEMS Reports

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“…Moreover, it inhibits inosine monophosphate dehydrogenase (IMPDH) activity, an enzyme involved in the de novo synthesis of guanine nucleotides. It was demonstrated that curcumin has antiviral activity against a broad group of viruses including HIV, HSV, HBV, HCV, and influenza [ 165 , 186 ].…”

Section: Antiviral Substances and Their Mechanisms Of Actionmentioning

confidence: 99%

Development of nanoparticle-delivery systems for antiviral agents: A review

Delshadi¹,

Bahrami

McClements

et al. 2021

Journal of Controlled Release

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“…Plant and microbial metabolites have been serving as an excellent and prolific source for a variety of medical agents since generations ( Newman and Cragg 2016 , 2020 ). Many such metabolites have been developed as latent therapeutic applications for human ailments including infectious diseases ( Sohail et al, 2011 ; Shabat et al, 2019; Pham et al, 2019 ). Furthermore, development of bioinformatics tools and services makes it easier and advantageous to screen a large number of compounds for their pharmacokinetics features and to predict their possible affinity towards several drug targets.…”

Section: Introductionmentioning

confidence: 99%

ADMET profile and virtual screening of plant and microbial natural metabolites as SARS-CoV-2 S1 glycoprotein receptor binding domain and main protease inhibitors

Padhi

Masi

Chourasia

et al. 2021

European Journal of Pharmacology

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In an attempt to search for selective inhibitors against the SARS-CoV-2 which caused devastating of lives and livelihoods across the globe, 415 natural metabolites isolated from several plants, fungi and bacteria, belonging to different classes, were investigated. The drug metabolism and safety profiles were computed in silico and the results showed seven compounds namely fusaric acid, jasmonic acid, jasmonic acid methyl ester, putaminoxin, putaminoxin B and D, and stagonolide K were predicted to having considerable absorption, metabolism, distribution and excretion parameters (ADME) and safety indices. Molecular docking against the receptor binding domain (RBD) of spike glycoprotein (S1) and the main protease (M pro ) exposed the compounds having better binding affinity to main protease as compared to the S1 receptor binding domain. The docking results were compared to an antiviral drug penciclovir reportedly of clinical significance in treating the SARS-CoV-2 infected patients. The results demonstrated the test compounds jasmonic acid, putaminoxins B and D bound to the HIS-CYS catalytic dyad as well as to other residues within the M Pro active site with much greater affinity than penciclovir. The findings of the study suggest that these compounds could be explored as potential SARS-CoV-2 inhibitors, and could further be combined with the experimental investigations to develop effective therapeutics to deal with the present pandemic.

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Plant as a Source of Natural Antiviral Agents

Cited by 54 publications

References 122 publications

Efficacy of Natural Compounds from Tinospora cordifolia Against SARS-CoV-2 Protease, Surface Glycoprotein and RNA Polymerase

Efficacy of Natural Compounds from Tinospora cordifolia Against SARS-CoV-2 Protease, Surface Glycoprotein and RNA Polymerase

Development of nanoparticle-delivery systems for antiviral agents: A review

ADMET profile and virtual screening of plant and microbial natural metabolites as SARS-CoV-2 S1 glycoprotein receptor binding domain and main protease inhibitors

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