Plant Antioxidants for Food Safety and Quality: Exploring New Trends of Research

Loi, Martina; Paciolla, Costantino

doi:10.3390/antiox10060972

Cited by 16 publications

(9 citation statements)

References 26 publications

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“…As the putative therapeutic role of the tocotrienols is fortified by its multiple roles in downregulating the oxidative, inflammatory, and cancerous responses 203 . The mechanism of action in antioxidants is neutralizing ROS and ROS‐induced intermediates by donating hydrogen atoms, which make them potent hydrogen (or proton) donors 204 . The antioxidant agents prevent further oxidation of ROS‐related biomolecules by participating in many rounds of peroxyl radical quenching and reduction by ascorbate or ubiquinone 205 …”

Section: Antioxidant and Anti‐inflammatory Activities Of Tocotrienolmentioning

confidence: 99%

Revisiting the therapeutic potential of tocotrienol

2022

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The therapeutic potential of the tocotrienol group stems from its nutraceutical properties as a dietary supplement. It is largely considered to be safe when consumed at low doses for attenuating pathophysiology as shown by animal models, in vitro assays, and ongoing human trials. Medical researchers and the allied sciences have experimented with tocotrienols for many decades, but its therapeutic potential was limited to adjuvant or concurrent treatment regimens. Recent studies have focused on targeted drug delivery by enhancing the bioavailability through carriers, self‐sustained emulsions, nanoparticles, and ethosomes. Epigenetic modulation and computer remodeling are other means that will help increase chemosensitivity. This review will focus on the systemic intracellular anti‐cancer, antioxidant, and anti‐inflammatory mechanisms that are stimulated and/or regulated by tocotrienols while highlighting its potent therapeutic properties in a diverse group of clinical diseases.

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Section: Antioxidant and Anti‐inflammatory Activities Of Tocotrienolmentioning

confidence: 99%

Revisiting the therapeutic potential of tocotrienol

2022

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“…Plants are rich in antioxidants, and it has further increased their importance in research in the field of health and functional food [26]. The activities of natural antioxidants are closely related to their functions.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Determination of LC-MS/MS phenolic profile, antioxidant and α-glucosidase enzyme inhibition activities of Linum mucronatum Bertol. subsp. armenum (Bordz.) P.H.Davis

KILIÇ>

Akar

2022

Turkish Journal of Analytical Chemistry

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Plants include compounds having high antioxidant activity such as flavonoids, phenolics, and carotenoids. Antioxidant defense mechanisms play an important role in the prevention and treatment of oxidative stress diseases in humans. In the present study, the flower and leaf parts of Linum mucronatum subsp. armenum were extracted in five different solvents. The antioxidant activities of the extracts were determine using six antioxidant activity determination assays (Iron (III) reducing/antioxidant power (FRAP), DPPH radical scavenging activity, copper (II) reducing antioxidant activity (CUPRAC), ABTS radical scavenging capacity, total flavonoid content and total phenolic content). While, the methanol extract showed the highest activity for the flower part, ethanol extracts of leaf part showed the highest antioxidant activity in the DPPH, FRAP and CUPRAC tests. The highest activity values in both flower and leaf parts was measured in acetone extract with SC50=0.287 mg/mL and (SC50=0.163 mg/mL in ABTS test, respectively. Lowest activity values of solvent extracts were measured in hexane extracts in all tests. Phenolic compounds of the plant were identified using LC-MS/MS. These phenolics are kaempferol, vanillin, protecatechuic acid, caffeic acid, p-coumaric acid, p-OH benzoic acid, salicylic acid, quercetin and rutin. The leaf and flower parts have α-glucosidase enzyme inhibitor effect. It was determined that the leaf part of the plant (IC50=4.533 mg/mL) have higher enzyme inhibition than in the flower (IC50=6.096 mg/mL). As a result, it was determined that the plant showed the biological activity. The results will contribute to the studies on the biological activity of the other plant.

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“…16 Of note, these compounds can convert hydroperoxides to nonradical derivatives such as alcohols; on the other hand, they can reduce the primary antioxidants that are inactivated by oxidation. 17 Metal deactivators such as benzotriazole and N-salicylidene ethylamine act as surface filmforming compounds or stable complex-forming agents (chelating agents), functioning through the reduction. 18,19 Hindered phenol antioxidants, as one of the most commonly used antioxidants, intercept chain propagation by blocking or reacting with free radicals (generated in the initiation stage of oxidation).…”

Section: Introductionmentioning

confidence: 99%

Antimigration Polypropylene Antioxidants: A Review

Li,

Zhang,

Jiang

et al. 2024

Ind. Eng. Chem. Res.

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Hindered phenolic antioxidants have been extensively recognized and applied to boost the heat resistance and oxidative aging performance of poly(propylene) (PP) composites. Low-molecular-weight antioxidants are easy to volatilize, migrate, and be extracted from PP or PP-based products, which can directly reduce the antithermal oxidative aging effect of PP and its composites, and it can contaminate food or drugs under its packaging. The design of an efficient and durable antioxidant with antimigration performance has drawn the attention of researchers. Currently, three main approaches are explored: (I) enhancement of molecular weight, that is, high molecular weight of antioxidants can stimulate the structure stability and the resistance toward migration; (II) inorganic immobilization, which involves immobilizing the antioxidants on inorganic substrate to enhance the dispersion and the antimigration performance; and (III) intercalation-mediated assembly, which involved intercalating low-molecular-weight antioxidants into the interlayer region of a layered host to boost antimigration performance based on the host–guest interaction.

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Plant Antioxidants for Food Safety and Quality: Exploring New Trends of Research

Abstract: Antioxidants are an heterogeneous group of compounds able to counteract cell oxidation by acting as reducing agents, as free radical scavengers, and quenchers of radical species and other pro-oxidants, such as metals [...]

Cited by 16 publications

References 26 publications

Revisiting the therapeutic potential of tocotrienol

Revisiting the therapeutic potential of tocotrienol

Determination of LC-MS/MS phenolic profile, antioxidant and α-glucosidase enzyme inhibition activities of Linum mucronatum Bertol. subsp. armenum (Bordz.) P.H.Davis

Antimigration Polypropylene Antioxidants: A Review

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