Plant & Its Derivative Shows Therapeutic Activity on Neuroprotective Effect

Abstract

In most cases, the death of neurons in certain parts of the brain is the defining feature of a condition that is classified as neurodegenerative. There have been studies conducted on both conventional and innovative drugs, however the results have shown that they only offer symptomatic advantages and come with a number of undesirable side effects. The finding of more potent compounds that can stop the pathophysiology of these diseases will be seen as a miracle in the present day. There is a wide variety of synthetic compounds accessible; nevertheless, these drugs may also create a broad range of additional health issues. As a consequence of this, scientists are looking to plants and other natural sources for the development of new medicines. In the practise of conventional medicine, it has been discovered that certain plants possess healing powers. The use of phytochemicals, which are produced from medicinal plants, may eventually replace the need for synthetic molecules. Numerous phytochemicals have been shown to be effective in the treatment of a wide range of diseases. This article discusses the potential therapeutic applications of plant-derived alkaloids for a number of neurodegenerative disorders (NDDs), including Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), epilepsy, schizophrenia, and stroke. There are many different types of alkaloids that can be found in the plant kingdom. Some of these alkaloids include isoquinoline, indole, pyrroloindole, oxindole, piperidine, pyridine, aporphine, vinca, -carboline, methylxanthene, lycopodium, and erythrine byproducts. Alkaloids have a beneficial effect on the pathophysiology of these diseases because of their ability to act as muscarinic and adenosine receptor agonists, anti-oxidants, anti-amyloid and MAO inhibitors, acetylcholinestrase and butyrylcholinesterase inhibitors, an inhibitor of synuclein aggregation, dopaminergic and nicotine agonists, and NMDA antagonists.

A Study of Various Medicinal Plants used in Ulcer Treatment: A Review

“…Originating in China, this plant is now widely cultivated in India for its decorative value. Flavonoids, anthocyanins, quercetin, cyanidin, kaempferol, and hydrocitric acid are all found inside this plant [45].…”

“…You can find it in its natural habitat in the Western Hemisphere and the sub-Himalayas, as well as in India, Pakistan, Asia Minor, Africa, and Arabia. Alkaloids, flavonoids, saponin, tannins, zeatin, quercetin, kaempferom, and terpenoids are all present in this plant [45].…”

“…Traditional medicines with anti-ulcer properties. Ulcers are historically treated using H. rosa sinensis root among the kani people in the Kanyakumari district of Tamil Nadu, India [45].…”

“…Kani tribal members in the Pechiparai Hills of Tamil Nadu, India use the leaf tea to heal stomach ulcers. In Pakistan, M. oleifera flower buds are extensively ingested due to their purported antiulcer properties [45].…”

Herbal used as Epigenetic for Cancer Treatment

“…On the other hand, the predictive biomarker is often integrated into the designs of clinical trials at a late stage in the clinical review process. For instance, in phase II research of combinations with DNA-damaging cytotoxics [64], it may be more acceptable to choose patients based on an epigenomic subtype of DDR genes as opposed to a histological subtype.…”