The use of keyboard and mouse combinations to navigate 3D environments of virtual worlds requires the coordination of both hands in order for the 2D degrees of motion of the mice to transform into the variety of motions available in a 3D presented by manufacturers as significant interface alternatives. To establish the feasibility of such claims, we have conducted a usability test of two 3D mice marketed by 3Dconnexion, in parallel with a keyboard+mouse test. The 10 participants had motor disabilities due to medullary lesions on vertebrae C5-D11, and performed 13 different tasks in the Second Life virtual world: 5 participants used 3D mice, 5 used keyboard+mouse. We have concluded that 2-3 of the 5 most challenging tasks in the keyboard+mouse combination become less cha more positive regarding 3D mice, but with significant differences between mice. Contrary to our initial expectations, the least stable mouse, Space Navigator, originated the best feedback.