Planar Induction of Anteroposterior Pattern in the Developing Central Nervous System of
            <i>Xenopus laevis</i>

Doniach, Tabitha; Phillips, Carey R.; Gerhart, John C.

doi:10.1126/science.1636091

Cited by 146 publications

(59 citation statements)

References 36 publications

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“…Stewart and Gerhart (1990) found that the width of the region in the late blastula that induces dorsal structures does not exceed 60". We noted above that Keller et al (199213) and Doniach et al (1992) found that planar signaling from the dorsal lip induces convergence extension and patterning in the neural plate. Our hypothesis is that even earlier planar signaling, from the vegetal cells at pregastrula stages, has a role in setting the boundaries of the neural plate.…”

Section: Introductionmentioning

confidence: 77%

“…Keller et al (199213) used "Keller" explants of Xenopus dorsal lip and adjacent ectoderm in which only planar induction can occur to show that planar induction from the dorsal lip up to stage 11 is sufficient to induce the convergence-extension movements of the neural plate. Doniach et al (1992) used similar explants and found that several position-specific neural marker genes were expressed in the ectoderm, suggesting that planar signals are sufficient to induce a patterned neural response. These examples confirm Spemann's idea that both methods of signaling do occur and are effective, and indeed suggest that planar signaling may be the more important.…”

Section: Introductionmentioning

confidence: 99%

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Evidence that the border of the neural plate may be positioned by the interaction between signals that induce ventral and dorsal mesoderm

Zhang

Jacobson

1993

Developmental Dynamics

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In the early Xenopus. embryo, a quadrant of endodermal cells that have descended from the vegetal dorsal localization in the zygote produces signals that pass into the animal hemisphere and induce dorsal mesoderm from the marginal zone. From the remaining three quadrants of the bordering endoderm, signals pass into the animal hemisphere and induce ventral mesoderm in the marginal region. There is evidence that suggests that these same mesoderm-inducing signals continue through the plane of the tissue of the animal hemisphere where they may at least begin the processes of neural and epidermal induction by changing the competence of the prospective ectodermal cells, and possibly influencing the early regional biasing of later expression of at least some gene products, such as Epi-1 whose expression in the future epidermal domain seems specified before gastrulation. We hypothesized that the interaction of the ventral and dorsal signals within the plane of the tissue of the animal hemisphere may position the border of the neural plate. If this is so, then transplantation into the animal pole of cells that signal induction of ventral mesoderm should drive the neural plate boundary back toward the blastopore and shorten the anterior-posterior axis. Removal of cells that induce ventral mesoderm should result in an axis that is longer than normal. Results of our experiments support these predictions. Also, by late pregastrula stage 9, increasing the ventral signals has no effect. Thus the evidence suggests that the position of the anterior neural plate boundary is established before gastrulation begins by the interaction of the signals that induce the ventral and dorsal mesoderm.

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Section: Introductionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Evidence that the border of the neural plate may be positioned by the interaction between signals that induce ventral and dorsal mesoderm

Zhang

Jacobson

1993

Developmental Dynamics

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“…36; Developmental Biology Hybridoma Bank) were also used. For detection of Hox-B9 and En, recombinants were harvested at stage 30 for whole mount immunohistochemistry as described by Doniach et al (37). These recombinants were sectioned after staining.…”

Section: Methodsmentioning

confidence: 99%

Anteroposterior neural tissue specification by activin-induced mesoderm

Green

Cook

Smith

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

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The transforming growth factor ␤ superfamily member, activin, is able to induce mesodermal tissues in animal cap explants from Xenopus laevis blastula stage embryos. Activin can act like a morphogen of the dorsoventral axis in that lower doses induce more ventral, and higher doses more dorsal, tissue types. Activin has also previously been reported to induce neural tissues in animal caps. From cell mixing experiments it was inferred that this might be an indirect effect of induced mesoderm signaling to uninduced ectoderm. Here we demonstrate directly that neural tissues do indeed arise by the action of induced mesoderm on uninduced ectoderm. Dorsal mesoderm is itself subdivided into posterior and anterior domains in vivo, but this had not been demonstrated for induced mesoderm. We therefore tested whether different concentrations of activin recreate these different anteroposterior properties as well. We show that the anteroposterior positional value of induced mesoderm, including its neuroinductive properties, depends on the dose of activin applied to the mesoderm, with lower doses inducing more posterior and higher doses giving more anterior markers. We discuss the implications of these results for patterning signals and the relationship between anteroposterior and dorsoventral axes.

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“…Organizer-derived posteriorizing signals reach neuroectoderm during gastrulation to specify the anteroposterior axis (Nieuwkoop 1952;Doniach et al 1992;Holowacz and Sokol 1999). Besides Wnt signaling, this process requires additional pathways, such as BMP and FGF signaling.…”

Section: Cross Talk With Other Pathwaysmentioning

confidence: 99%