Evidence that the border of the neural plate may be positioned by the interaction between signals that induce ventral and dorsal mesoderm

Zhang, Jing; Jacobson, Antone G.

doi:10.1002/aja.1001960202

Cited by 21 publications

(7 citation statements)

References 30 publications

(25 reference statements)

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“…Grocott et al / Developmental Biology 370 (2012) 3-23 et al, 2003. Neural and non-neural transcripts continue to overlap in a broad territory, named 'the border' of the neural plate (Moury and Jacobson, 1989;Streit and Stern, 1999;Zhang and Jacobson, 1993), and it is in this region that precursors for neural, neural crest, placodes and epidermis are intermingled (Ezin et al, 2009;Fernandez-Garre et al, 2002;Garcia-Martinez et al, 1993;Hatada and Stern, 1994) and Irx1, one of the Six and Eya upstream regulators, is switched on under the influence of BMP and FGF signalling (Bellefroid et al, 1998;Glavic et al, 2002;Gomez-Skarmeta et al, 1998;Goriely et al, 1999;Khudyakov and Bronner-Fraser, 2009) (Figs. 2 and 3).…”

Section: Subdivision Of the Ectoderm By Sequential Activation Of Tranmentioning

confidence: 99%

The peripheral sensory nervous system in the vertebrate head: A gene regulatory perspective

Grocott

Tambalo

Streit

2012

Developmental Biology

140

224

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In the vertebrate head, crucial parts of the sense organs and sensory ganglia develop from special regions, the cranial placodes. Despite their cellular and functional diversity, they arise from a common field of multipotent progenitors and acquire distinct identity later under the influence of local signalling. Here we present the gene regulatory network that summarises our current understanding of how sensory cells are specified, how they become different from other ectodermal derivatives and how they begin to diversify to generate placodes with different identities. This analysis reveals how sequential activation of sets of transcription factors subdivides the ectoderm over time into smaller domains of progenitors for the central nervous system, neural crest, epidermis and sensory placodes. Within this hierarchy the timing of signalling and developmental history of each cell population is of critical importance to determine the ultimate outcome. A reoccurring theme is that local signals set up broad gene expression domains, which are further refined by mutual repression between different transcription factors. The Six and Eya network lies at the heart of sensory progenitor specification. In a positive feedback loop these factors perpetuate their own expression thus stabilising pre-placodal fate, while simultaneously repressing neural and neural crest specific factors. Downstream of the Six and Eya cassette, Pax genes in combination with other factors begin to impart regional identity to placode progenitors. While our review highlights the wealth of information available, it also points to the lack information on the cis-regulatory mechanisms that control placode specification and of how the repeated use of signalling input is integrated.

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Section: Subdivision Of the Ectoderm By Sequential Activation Of Tranmentioning

confidence: 99%

The peripheral sensory nervous system in the vertebrate head: A gene regulatory perspective

Grocott

Tambalo

Streit

2012

Developmental Biology

140

224

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“…Xsna mRNA is a marker of a compartment that surrounds the neural plate from stage 11 in both the deep and superficial layers. In recognition of its precise differentiation from neighbouring tissues we designate it the neural plate border (also suggested by Zhang and Jacobson, 1993;Coffman et al, 1993). The boundaries of what will be within the closed neural tube is marked precisely in mid-gastrulae by the ventral edge of the superficial ectoderm border and the dorsal edge of the deep ectoderm border.…”

Section: The Neural Plate Bordermentioning

confidence: 99%

“…8A). In the other, Zhang and Jacobson, (1993) have shown using transplantation experiments that the position of the anterior neural plate border is determined by the relative strengths of two distinct signals emanating from the vegetal pole, one on the dorsal side with a neuralising effect and another on the ventral side which produces epidermis. Ectoder-ma1 Xsna is evidently a marker of an important element in this interaction.…”

Section: The Neural Plate Bordermentioning

confidence: 99%

Expression of Xenopus snail in mesoderm and prospective neural fold ectoderm

Essex

Mayor

Sargent

1993

Developmental Dynamics

126

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Expression of the Xsna gene during Xenopus laevis embryogenesis has been analysed by in situ hybridisation. Like its homol o p e snail in Drosophila, Xsna is expressed zygotically in all early mesoderm. Expression starts during stage 9 in the dorsal marginal zone and spreads to the ventral side by stage 10. During gastrulation, each cell begins to express as it involutes so that cells newly expressing Xsna are added to the forming mesoderm mantle in an anterior-to-posterior progression. Xsna expression is then down-regulated in a tissue-specific fashion that reveals the subdivision of the mesoderm before its derivatives are overtly differentiated; e.g., the appearance of the notochord, myotomes, and pronephroi are preceded by the disappearance of Xsna mRNA, while undifferentiated mesoderm remains labelled, even into tadpole stages. Xsna is expressed in the suprablastoporal endoderm during gastrulation and in its derivatives, the prechordal and sub-notochordal endoderm, during neurulation. Relationships between Xbra, Xtwi, and Xsna expression are examined.Xsna is also expressed in the prospective neural fold ectoderm from stage 11 in a low arc above the dorsal marginal zone, precisely identifying a distinct band of cells that surrounds the prospective neural plate that we designate the neural plate border. The anterior transverse neural fold, which becomes forebrain, ceases Xsna expression during neurulation. In the longitudinal neural folds, the deep and superficial ectoderm compartments labelled by Xsna expression are the prospective neural crest and prospective roof of the neural tube, respectively. Xsna expression persists in the neural crest during migration and in some derivatives at least until metamorphosis but ceases in the roof of the neural tube soon after neurulation. 0 1993 Wiley-Liss, Inc.

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“…Because this time precedes the morphological appearance and expression of molecular markers of neural folds and lateral primary neurons, neural crest cells and cranial placodes, Dlx activity is needed upstream of the process that induces these cell fates. Classical graft and extirpation experiments suggested that the anterior neural plate border is no longer susceptible to signals that reposition the border by late blastula stage (stage 9+) (Zhang and Jacobson, 1993). While the mediolateral border was not examined specifically, it is possible that these studies revealed the action of diffusible signals, such as BMP and Wnt, that bias ectodermal fates.…”

Section: Activity Regulates Cell Fates During Gastrulationmentioning

confidence: 99%

Dlx proteins position the neural plate border and determine adjacent cell fates

et al. 2003

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The lateral border of the neural plate is a major source of signals that induce primary neurons, neural crest cells and cranial placodes as well as provide patterning cues to mesodermal structures such as somites and heart. Whereas secreted BMP, FGF and Wnt proteins influence the differentiation of neural and non-neural ectoderm, we show here that members of the Dlx family of transcription factors position the border between neural and non-neural ectoderm and are required for the specification of adjacent cell fates. Inhibition of endogenous Dlx activity in Xenopus embryos with an EnR-Dlx homeodomain fusion protein expands the neural plate into non-neural ectoderm tissue whereas ectopic activation of Dlx target genes inhibits neural plate differentiation. Importantly, the stereotypic pattern of border cell fates in the adjacent ectoderm is reestablished only under conditions where the expanded neural plate abuts Dlx-positive non-neural ectoderm. Experiments in which presumptive neural plate was grafted to ventral ectoderm reiterate induction of neural crest and placodal lineages and also demonstrate that Dlx activity is required in non-neural ectoderm for the production of signals needed for induction of these cells. We propose that Dlx proteins regulate intercellular signaling across the interface between neural and non-neural ectoderm that is critical for inducing and patterning adjacent cell fates.

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Evidence that the border of the neural plate may be positioned by the interaction between signals that induce ventral and dorsal mesoderm

Cited by 21 publications

References 30 publications

The peripheral sensory nervous system in the vertebrate head: A gene regulatory perspective

The peripheral sensory nervous system in the vertebrate head: A gene regulatory perspective

Expression of Xenopus snail in mesoderm and prospective neural fold ectoderm

Dlx proteins position the neural plate border and determine adjacent cell fates

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