Plakophilin3 loss leads to increased adenoma formation and rectal prolapse in APCmin mice

Raghavan, Rahul; Koyande, Navami; Beher, Rohit; Chetlangia, Neha; Ramadwar, Mukda; Pawade, Shital; Thorat, Rahul; Hengel, Jolanda van; Sklyarova, Tetyana; Roy, Frans van; Dalal, Sorab N.

doi:10.1016/j.bbrc.2021.11.071

Cited by 7 publications

(5 citation statements)

References 21 publications

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“…Furthermore, PKP3 downregulation induces matrilysin (MMP7) expression by promoting PRL3 expression and thus promotes the invasion of HCT116 colon cancer cells and tumor formation of colon cancer 25 . Additionally, PKP3 directly interacts with p38MAPK to block its translocation to the nucleus, while PKP3 loss promotes its phosphorylated activation and nuclear localization, which finally leads to metastasis and growth of HCT116 colon cancer cells through increasing expression of lipocalin 2 (LCN2) 26,27 . Loss of PKP3 induces autophagy and reactive oxygen species clearance by activating p38MAPK, then increases radioresistance and promotes survival of HCT116 colon cancer cells 28 .…”

Section: Plakophilin 3 Plays Important Role In Cancer Progressionmentioning

confidence: 99%

“… 25 Additionally, PKP3 directly interacts with p38MAPK to block its translocation to the nucleus, while PKP3 loss promotes its phosphorylated activation and nuclear localization, which finally leads to metastasis and growth of HCT116 colon cancer cells through increasing expression of lipocalin 2 (LCN2). 26 , 27 Loss of PKP3 induces autophagy and reactive oxygen species clearance by activating p38MAPK, then increases radioresistance and promotes survival of HCT116 colon cancer cells. 28 In addition, several proteins have been identified to regulate PKP3 expression during tumor metastasis in a variety of cancers.…”

Section: Plakophilin 3 Plays Important Role In Cancer Progressionmentioning

confidence: 99%

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Role and function of plakophilin 3 in cancer progression and skin disease

Zhang,

Chen,

Tian

et al. 2023

Cancer Science

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Plakophilin 3 (PKP3), a component of desmosome, is aberrantly expressed in many kinds of human diseases, especially in cancers. Through direct interaction, PKP3 binds with a series of desmosomal proteins, such as desmoglein, desmocollin, plakoglobin, and desmoplakin, to initiate desmosome aggregation, then promotes its stability. As PKP3 is mostly expressed in the skin, loss of PKP3 promotes the development of several skin diseases, such as paraneoplastic pemphigus, pemphigus vulgaris, and hypertrophic scar. Moreover, accumulated clinical data indicate that PKP3 dysregulates in diverse cancers, including breast, ovarian, colon, and lung cancers. Numerous lines of evidence have shown that PKP3 plays important roles in multiple cellular processes during cancer progression, including metastasis, invasion, tumor formation, autophagy, and proliferation. This review examines the diverse functions of PKP3 in regulating tumor formation and development in various types of cancers and summarizes its detailed mechanisms in the occurrence of skin diseases.

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Section: Plakophilin 3 Plays Important Role In Cancer Progressionmentioning

confidence: 99%

Section: Plakophilin 3 Plays Important Role In Cancer Progressionmentioning

confidence: 99%

Role and function of plakophilin 3 in cancer progression and skin disease

Zhang,

Chen,

Tian

et al. 2023

Cancer Science

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“…Similarly, when compared to benign tumors, cancer cells have frequently been found to contain a great number of genetic defects and altered gene expression [ 39 ]. Altered expression of tumor suppression genes, increased proliferation, increased growth signals, and increased metastasis are examples of specific characteristics of malignant tumors [ 40 , 41 , 42 , 43 ].…”

Section: Distinguishing Premalignant From Malignant Lesionsmentioning

confidence: 99%

Advances in Nanotechnology for Cancer Immunoprevention and Immunotherapy: A Review

et al. 2022

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One of the most effective cancer therapies, cancer immunotherapy has produced outstanding outcomes in the field of cancer treatment. However, the cost is excessive, which limits its applicability. A smart way to address this issue would be to apply the knowledge gained through immunotherapy to develop strategies for the immunoprevention of cancer. The use of cancer vaccines is one of the most popular methods of immunoprevention. This paper reviews the technologies and processes that support the advantages of cancer immunoprevention over traditional cancer immunotherapies. Nanoparticle drug delivery systems and nanoparticle-based nano-vaccines have been employed in the past for cancer immunotherapy. This paper outlines numerous immunoprevention strategies and how nanotechnology can be applied in immunoprevention. To comprehend the non-clinical and clinical evaluation of these cancer vaccines through clinical studies is essential for acceptance of the vaccines.

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“…Dysregulation of PKP3 in tumor cells leads to altered desmosome size, reduced intercellular adhesion, and increased cell migration, further contributing to tumor progression [ 14 ]. Previous investigations have presented the contribution of PKP3 in the initiation of multiple tumors, such as colon, lung, prostate, ovarian, and breast malignancies [ 15 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…Recent investigations have revealed that the deficiency of PKP3 in a mouse model of colon cancer is connected with the upregulation of Lipocalin2, leading to adenoma formation, rectal prolapse, and reduced survival [ 15 ]. PKP3 functions in the tumor microenvironment of prostate cancer, regulating invasion of the cell and development of the tumor through the MMP7 protein, and is associated with poor patient prognosis.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis Identifies PKP3 Overexpression in Pancreatic Cancer Related to Unfavorable Prognosis

Du,

Hou,

Chen

et al. 2023

Biomedicines

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Plakophilin 3 (PKP3) affects cell signal transduction and cell adhesion and performs a crucial function in tumorigenesis. The current investigation evaluated the predictive significance and underlying processes of PKP3 within pancreatic cancer (PC) tissues. The assessment of differences in PKP3 expression was conducted through an analysis of RNA-seq data acquired from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Additionally, clinical samples were collected to validate the findings. The predictive significance of PKP3 was investigated by analyzing survival data derived from TCGA and clinical specimens. PKP3′s biological function was assessed via phenotypic experiments after the suppression of PKP3 expression within PC cells. Functional enrichment analysis, encompassing KEGG, GO, and GSEA, was employed to assess the underlying mechanism of PKP3. Immune infiltration analysis was conducted in the present investigation to determine the association between PKP3 and tumor-infiltrating immune cells (TICs). In PC tissues, PKP3 expression was abnormally upregulated and correlated with a negative prognosis in individuals with PC. PKP3 can promote the progression, migration, and invasive capacity of PC cells and is relevant to the regulation of the PI3K–Akt and MAPK signaling pathways. Immune infiltration analysis demonstrated that PKP3 impeded CD8+ T-cell infiltration and immune cytokine expression within the tumor microenvironment. The PKP3 protein was identified as a prospective independent predictive indicator and represents a viable approach for immunotherapy in the context of PC. PKP3 may impact prognosis by broadly inhibiting immune cell infiltration and promoting the activation of tumor-associated signaling pathways.

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Plakophilin3 loss leads to increased adenoma formation and rectal prolapse in APCmin mice

Cited by 7 publications

References 21 publications

Role and function of plakophilin 3 in cancer progression and skin disease

Role and function of plakophilin 3 in cancer progression and skin disease

Advances in Nanotechnology for Cancer Immunoprevention and Immunotherapy: A Review

Comprehensive Analysis Identifies PKP3 Overexpression in Pancreatic Cancer Related to Unfavorable Prognosis

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