Advances in Nanotechnology for Cancer Immunoprevention and Immunotherapy: A Review

Koyande, Navami; Srivastava, Rupali; Padmakumar, Ananya; Rengan, Aravind Kumar

doi:10.3390/vaccines10101727

Cited by 7 publications

(4 citation statements)

References 223 publications

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“…In the world of medicine, complex and incurable diseases such as cancer are always given a special focus to find treatment and early diagnosis options for these modalities [ 113 ]. Nanotechnology is providing a good opportunity for researchers to develop such nano-agents, fluorescent materials, molecular diagnostics kits, and specific targeted drugs that may help to diagnose and cure disease in a better way in the future [ 114 ].…”

Section: Results and Discussion—applications Of Nanotechnology In The...mentioning

confidence: 99%

“…Nanotechnology is providing a good opportunity for researchers to develop such nano-agents, fluorescent materials, molecular diagnostics kits, and specific targeted drugs that may help to diagnose and cure disease in a better way in the future [ 114 ]. Scientists are trying various protocols to conjugate already available drugs with nanoparticles to enhance drug specificity and targeting in organs [ 113 , 114 , 115 ].…”

Section: Results and Discussion—applications Of Nanotechnology In The...mentioning

confidence: 99%

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Emerging Applications of Nanotechnology in Healthcare and Medicine

Malik,

Muhammad,

Waheed

2023

Molecules

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Knowing the beneficial aspects of nanomedicine, scientists are trying to harness the applications of nanotechnology in diagnosis, treatment, and prevention of diseases. There are also potential uses in designing medical tools and processes for the new generation of medical scientists. The main objective for conducting this research review is to gather the widespread aspects of nanomedicine under one heading and to highlight standard research practices in the medical field. Comprehensive research has been conducted to incorporate the latest data related to nanotechnology in medicine and therapeutics derived from acknowledged scientific platforms. Nanotechnology is used to conduct sensitive medical procedures. Nanotechnology is showing successful and beneficial uses in the fields of diagnostics, disease treatment, regenerative medicine, gene therapy, dentistry, oncology, aesthetics industry, drug delivery, and therapeutics. A thorough association of and cooperation between physicians, clinicians, researchers, and technologies will bring forward a future where there is a more calculated, outlined, and technically programed field of nanomedicine. Advances are being made to overcome challenges associated with the application of nanotechnology in the medical field due to the pathophysiological basis of diseases. This review highlights the multipronged aspects of nanomedicine and how nanotechnology is proving beneficial for the health industry. There is a need to minimize the health, environmental, and ethical concerns linked to nanotechnology.

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Section: Results and Discussion—applications Of Nanotechnology In The...mentioning

confidence: 99%

Section: Results and Discussion—applications Of Nanotechnology In The...mentioning

confidence: 99%

Emerging Applications of Nanotechnology in Healthcare and Medicine

Malik,

Muhammad,

Waheed

2023

Molecules

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“…The chimeric antigen receptor T cell (CAR-T cell) is one of the prominent applications of immunotherapeutic plasmids [ 59 ]. Cells are treated with plasmid DNA to elicit immune responses against the encoded antigen [ 60 ]. Early research using mice showed that plasmid DNA may trigger immune responses against cancer, influenza, and HIV-1 transgenic products, establishing DNA as a viable vaccination platform [ 61 ].…”

Section: Nucleic Acid Types and Structurementioning

confidence: 99%

Smart Nanocarriers for the Targeted Delivery of Therapeutic Nucleic Acid for Cancer Immunotherapy

et al. 2023

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A wide variety of therapeutic approaches and technologies for delivering therapeutic agents have been investigated for treating cancer. Recently, immunotherapy has achieved success in cancer treatment. Successful clinical results of immunotherapeutic approaches for cancer treatment were led by antibodies targeting immune checkpoints, and many have advanced through clinical trials and obtained FDA approval. A major opportunity remains for the development of nucleic acid technology for cancer immunotherapy in the form of cancer vaccines, adoptive T-cell therapies, and gene regulation. However, these therapeutic approaches face many challenges related to their delivery to target cells, including their in vivo decay, the limited uptake by target cells, the requirements for nuclear penetration (in some cases), and the damage caused to healthy cells. These barriers can be avoided and resolved by utilizing advanced smart nanocarriers (e.g., lipids, polymers, spherical nucleic acids, metallic nanoparticles) that enable the efficient and selective delivery of nucleic acids to the target cells and/or tissues. Here, we review studies that have developed nanoparticle-mediated cancer immunotherapy as a technology for cancer patients. Moreover, we also investigate the crosstalk between the function of nucleic acid therapeutics in cancer immunotherapy, and we discuss how nanoparticles can be functionalized and designed to target the delivery and thus improve the efficacy, toxicity, and stability of these therapeutics.

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“…In recent years, nanoparticle drug delivery systems have displayed tremendous potential in cancer immunotherapy. − Especially, with a deeper understanding of the biological process in vivo of drug delivery system and mechanism of tumor immune escape, cell-derived biomimetic nanodelivery systems (BNDS) have been designed to improve the therapeutic potential and decrease adverse reaction . Interestingly, BNDS can ideally overcome the diversiform obstacles due to their biological characteristics.…”

Section: Introductionmentioning

confidence: 99%