Plague in Brazil: From Now and Then

Tavares, Celso; Aragão, Antônia Ivoneida; Leal, Nilma Cintra; Leal-Balbino, Tereza Cristina; Oliveira, Maria Betânia Melo de; Ferreira, Geane Maria de Oliveira Gonçalves; Almeida, Alzira Maria Paiva de

doi:10.1007/978-1-4614-3561-7_10

Cited by 16 publications

(39 citation statements)

References 20 publications

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“…The Y. pestis strain collection resulting from these activities is a unique and irreplaceable resource, containing all of the available temporal, geographic and genetic diversity of Y. pestis strains from Brazil, and is of incalculable value for future comparative studies of Brazilian plague (Tavares et al . ). Preservation of this collection is thus of the highest importance.…”

Section: Introductionmentioning

confidence: 97%

“…Subsequent plague surveillance and control activities in these established foci from 1966 to 1997 led to the isolation of hundreds of Y. pestis strains from rodents, fleas and humans in these areas (Almeida et al 1985Baltazard 2004). The Y. pestis strain collection resulting from these activities is a unique and irreplaceable resource, containing all of the available temporal, geographic and genetic diversity of Y. pestis strains from Brazil, and is of incalculable value for future comparative studies of Brazilian plague (Tavares et al 2012). Preservation of this collection is thus of the highest importance.…”

Section: Introductionmentioning

confidence: 99%

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Viability of Yersinia pestis subcultures in agar stabs

Leal

Sobreira

Araujo

et al. 2015

Lett Appl Microbiol

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We report the ability of Yersinia pestis to survive up to 47 years in agar stabs, in rubber-stoppered tubes, under refrigeration (+4 to +10°C), although overall subculture recovery rates were poor and inversely related to the length of time stored. Genetic characterization of virulence gene presence among these subcultures was suggestive of significant variation in the genomic stability of Y. pestis subcultures stored under these conditions. This variation, together with all of the inherent temporal, geographic and other genetic variation represented by all of the recoverable strains in the historical 'Collection of Yersinia pestis' (Fiocruz-CYP) maintained by the SRP of FIOCRUZ-PE in Brazil was preserved in new frozen culture stocks stored at -70°C as a result of this study. These frozen culture stocks represent a valuable resource for future comparative studies of Y. pestis.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Viability of Yersinia pestis subcultures in agar stabs

Leal

Sobreira

Araujo

et al. 2015

Lett Appl Microbiol

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“…Esses focos são remanescentes da introdução da infecção pelo porto de Santos, SP durante a última pandemia em 1899 (figura 1). Até a década de 1980, ocorriam surtos a cada 5 -10 anos, que eram entremeados por períodos variáveis de quiescência 4 ; porém, a maioria das áreas focais não apresenta notificações há mais de 50 anos, apesar da detecção da circulação da Yersinia pestis, o seu agente etiológico, em animais sentinela 5,6 . Desde 2005, casos suspeitos isolados são notificados, mas todos eles têm sido, sistematicamente, descartados laboratorialmente 5,6 .…”

Section: Introductionunclassified

Peste, uma zoonose esquecida

Tavares¹,

Leal

Sobreira

et al. 2020

J Health Biol Sci.

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ResumoObjective: to characterize ground epidemiological and clinical aspects of, discuss the methodology of diagnosis and draw recommendations about the management of suspect cases of plague. Methods: literature review and data collection of hospitalizations and deaths due to plague recorded in the Hospital Information System of the Unified Health System. Results and conclusions: the existence of mistaken diagnoses of a potentially fatal disease, as well as hypothetical records of hospitalization and deaths, is a challenge to be overcome, because it reflects an unacceptable panorama in which a possible and unusual diagnosis is not investigated and accumulates in the information systems. AbstractObjetivo: caracterizar aspectos epidemiológicos e clínicos fundamentais, discutir a metodologia do diagnóstico e tecer recomendações sobre as condutas perante a suspeição de casos de peste. Métodos: revisão bibliográfica e levantamento das internações e mortes por peste registradas no Sistema de Informações Hospitalares do Sistema Único de Saúde. Resultados e conclusões: a existência de diagnósticos equivocados de uma doença potencialmente fatal, além dos registros hipotéticos de internações e mortes, constitui um desafio a ser superado, pois espelha uma situação inaceitável, em que um possível e insólito diagnóstico não é investigado e acumula-se nos sistemas de informação. Palavras-chave:Peste. Yersinia pestis. Focos naturais. Epidemiologia. Diagnóstico.

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“…The zoonosis remains in these foci, alternating between quiescent periods and epizootics, a phenomenon expressed by high rodent mortality and sporadic human cases 6 .…”

mentioning

confidence: 99%

“…Brazilian focal plague areas are continuously monitored through serological surveys of domestic carnivores [dogs (Canis lupus familiaris) and cats (Felis catus)], and the serological analyses are performed at the Central Laboratory of Public Health (LACEN) in the focal area states 6,7 .…”

mentioning

confidence: 99%

Seroprevalence and spatial distribution dynamics of Yersinia pestis antibodies in dogs and cats from plague foci in the State of Ceará, Northeastern Brazil

Sousa

Alencar

Almeida

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction:In Brazil, the plague is established in several foci located mainly in the northeastern part of the country, where it alternates between active and quiescent periods. These foci in the State of Ceará have high epidemiological importance. In addition to other plague detection activities, plague areas can be monitored through serological surveys of dogs and cats (domestic carnivores), which, following feeding on plague-infected rodents, can develop mild to severe forms of the disease and produce long-lasting antibodies. This study aimed to characterize the circulation dynamics and spatial distribution of Yersinia pestis antibodies in dogs and cats in plague foci areas of Ceará. Methods: An ecological study was conducted to analyze the temporal series and spatial distribution of secondary data obtained from domestic carnivore serum surveillance in Ceará's plague areas from 1990 to 2014. Results: Joinpoint analysis revealed that the overall trend was a reduction in antibody-positive animals. The mean proportion of antibody-positivity during the whole study period was 1.5% (3,023/203,311) for dogs, and 0.7% (426/61,135) for cats, with more than 4% antibody-positivity in dogs in 1997 and 2002. Antibody titers ranging from 1/16 to 1/64 were frequent. Despite fluctuations and a significant reduction, in recent years, there were antibody-positive animals annually throughout the study period, and the localities containing antibody-positive animals increased in number. Conclusion: Yersinia pestis is actively circulating in the study areas, posing a danger to the human population.

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Plague in Brazil: From Now and Then

Cited by 16 publications

References 20 publications

Viability of Yersinia pestis subcultures in agar stabs

Viability of Yersinia pestis subcultures in agar stabs

Peste, uma zoonose esquecida

Seroprevalence and spatial distribution dynamics of Yersinia pestis antibodies in dogs and cats from plague foci in the State of Ceará, Northeastern Brazil

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