Placental volume measured by three‐dimensional ultrasound in the prediction of fetal α<sup>0</sup>‐thalassemia: a preliminary report

Chen, M.; Leung, Kwok; Lee, C. P.; Tang, Mary Hoi Yin; Ho, Pak Chung

doi:10.1002/uog.2721

Cited by 29 publications

(27 citation statements)

References 28 publications

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“…The 30° rotation method resulted in a wider range of intra-observer 95% limits of agreement than the 15° method. Differing reproducibility data have been reported for 3D measurements and analyses of placental volume, varying from relatively poor to highly similar intra-and inter-observer agreement [39,42-46]]. The results of this study are similar to those of Cheong et al, who reported that measurements made with VOCAL 30°, in an ex-vivo experiment, were faster to complete, but associated with significantly higher variability than those made with VOCAL 12° [18].…”

Section: Discussionsupporting

confidence: 75%

Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study

Rijken

Moroski

Kiricharoen

et al. 2012

Malar J

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BackgroundThe presence of malaria parasites and histopathological changes in the placenta are associated with a reduction in birth weight, principally due to intrauterine growth restriction. The aim of this study was to examine the feasibility of studying early pregnancy placental volumes using three-dimensional (3D) ultrasound in a malaria endemic area, as a small volume in the second trimester may be an indicator of intra-uterine growth restriction and placental insufficiency.MethodsPlacenta volumes were acquired using a portable ultrasound machine and a 3D ultrasound transducer and estimated using the Virtual Organ Computer-aided AnaLysis (VOCAL) image analysis software package. Intra-observer reliability and limits of agreement of the placenta volume measurements were calculated. Polynomial regression models for the mean and standard deviation as a function of gestational age for the placental volumes of uninfected women were created and tested. Based on these equations each measurement was converted into a z -score. The z-scores of the placental volumes of malaria infected and uninfected women were then compared.ResultsEighty-four women (uninfected = 65; infected = 19) with a posterior placenta delivered congenitally normal, live born, single babies. The mean placental volumes in the uninfected women were modeled to fit 5th, 10th, 50th, 90th and 95th centiles for 14-24 weeks' gestation. Most placenta volumes in the infected women were below the 50th centile for gestational age; most of those with Plasmodium falciparum were below the 10th centile. The 95% intra-observer limits of agreement for first and second measurements were ± 37.0 mL and ± 25.4 mL at 30 degrees and 15 degrees rotation respectively.ConclusionThe new technique of 3D ultrasound volumetry of the placenta may be useful to improve our understanding of the pathophysiological constraints on foetal growth caused by malaria infection in early pregnancy.

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Section: Discussionsupporting

confidence: 75%

Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study

Rijken

Moroski

Kiricharoen

et al. 2012

Malar J

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“…Aside from the 2‐dimensional placental thickness measurement described above, it has been reported that 3‐dimensional sonography might also facilitate the analysis of placental volume in early pregnancy 46 . Although its efficiency in predicting fetuses with α‐thalassemia was not validated in a pilot study 47 because of the limited number of affected fetuses (11 cases), we still believe that further 3‐dimensional sonographic studies with larger sample sizes could be helpful.…”

Section: Sonographic Markers Of Fetal α‐Thalassemia Majormentioning

confidence: 99%

Sonographic Markers of Fetal α‐Thalassemia Major

Zhou

Zhang

et al. 2015

J of Ultrasound Medicine

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α‐Thalassemia prevails in Southeast Asia, where α‐thalassemia major is a lethal type. Sonography is a helpful and cost‐effective screening tool for detecting α‐thalassemia major fetuses. The cardiothoracic ratio, placental thickness, and middle cerebral artery peak systolic velocity are most used in clinical practice. These sensitive markers are helpful for evaluation of the hemodynamic status and cardiovascular function of the affected fetuses. They can predict fetal α‐thalassemia major and assess the efficacy of treatment noninvasively; therefore, the medical costs as well as the possibility of fetal loss caused by invasive procedures can be reduced. Other potentially useful sonographic markers need further studies, although previous preliminary research suggests their usefulness. This article will review those sonographic markers.

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“…Placental volume measurement and uterine artery Doppler in the first trimester may be used to identify women at risk of subsequent development of pregnancy complications such as pre‐eclampsia, pregnancy‐induced hypertension, preterm placental abruption or fetal growth restriction2–4. Furthermore, assessment of placental volume may be useful in first‐trimester risk assessment for chromosomal anomalies5 and homozygous α 0 ‐thalassemia6.…”

Section: Introductionmentioning

confidence: 99%

Comparison of inter‐ and intraobserver agreement and reliability between three different types of placental volume measurement technique (XI VOCAL^™, VOCAL^™ and multiplanar) and validity in the in‐vitro setting

Cheong

Leung

et al. 2010

Ultrasound in Obstet & Gyne

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Placental volume measured by three‐dimensional ultrasound in the prediction of fetal α⁰‐thalassemia: a preliminary report

Abstract: Objective To evaluate the use of placental volume measured by three-dimensional (3D)

Cited by 29 publications

References 28 publications

Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study

Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study

Sonographic Markers of Fetal α‐Thalassemia Major

Comparison of inter‐ and intraobserver agreement and reliability between three different types of placental volume measurement technique (XI VOCAL^™, VOCAL^™ and multiplanar) and validity in the in‐vitro setting

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Placental volume measured by three‐dimensional ultrasound in the prediction of fetal α0‐thalassemia: a preliminary report

Abstract: Objective To evaluate the use of placental volume measured by three-dimensional (3D)

Cited by 29 publications

References 28 publications

Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study

Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study

Sonographic Markers of Fetal α‐Thalassemia Major

Comparison of inter‐ and intraobserver agreement and reliability between three different types of placental volume measurement technique (XI VOCAL™, VOCAL™ and multiplanar) and validity in the in‐vitro setting

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Placental volume measured by three‐dimensional ultrasound in the prediction of fetal α⁰‐thalassemia: a preliminary report

Comparison of inter‐ and intraobserver agreement and reliability between three different types of placental volume measurement technique (XI VOCAL^™, VOCAL^™ and multiplanar) and validity in the in‐vitro setting