Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague Dawley rats

Doerge, Daniel R.; Churchwell, Mona I.; Chang, Hebron C.; Newbold, Retha R.; Delclos, K. Barry

doi:10.1016/s0890-6238(01)00108-3

Cited by 106 publications

(78 citation statements)

References 17 publications

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“…Strauss et al [29] reported that in adult male mice, genistein induced typical estrogenic effects in doses comparable to those present in soybean-based diets, while in neonatal animals, considerably higher doses were required to show estrogen-like activity. These adverse effects may be due to the ability of genistein to cross placenta and reach the fetal brain at maternal serum genistein levels that are comparable to those observed in humans [30]. These reports suggest that dietary genistein ranges available in humans produce effects in multiple estrogen-sensitive tissues in males and females that are generally consistent with its estrogenic activity [13].…”

Section: Discussionmentioning

confidence: 67%

Effects of Exposure to Genistein during Pubertal Development on the Reproductive System of Male Mice

Lee

Jung

Yun

et al. 2004

Journal of Reproduction and Development

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Abstract. Genistein, a soybean-originated isoflavone, is widely consumed by humans for putative beneficial health effects but its estrogenic activity may affect adversely the development of the male reproductive system. Twenty-one days old ICR mice weaned from dams fed with a casein-based AIN-76A diet during gestation and lactation were exposed to genistein (2.5 and 5.0 mg/kg/day, p.o.) for 5 weeks. 17β-Estradiol (7.5 µg/kg/day) and corn oil were used for the positive and negative vehicle controls, respectively. The animals were fed the casein-based AIN-76A diet throughout the experiment. There were no significant differences in body weights of mice between the genistein groups and the negative control group. No significant differences in relative reproductive organ weights were found among all experimental groups. Sperm counts in epididymis and testes were slightly decreased in the genistein-exposed groups compared with control group. Sperm motile characteristics in genistein-exposed groups were slightly higher than those of the control group. Levels of phospholipid hydroxide glutathione peroxidase mRNA in the testis, epididymis, and prostate of mice exposed to genistein or estradiol were significantly higher than those of the controls (P<0.05). Exposure to genistein caused hyperplasia of Leydig cells in the testis and a slight increase of interstitial fibroblasts in the epididymis, while estradiol treatment caused severe damage to the testis and epididymis. These results suggest that dietary uptake of genistein during the juvenile period may affect male reproductive development, resulting in a slight decrease in sperm count, but with an increase in sperm motion quality.

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Section: Discussionmentioning

confidence: 67%

Effects of Exposure to Genistein during Pubertal Development on the Reproductive System of Male Mice

Lee

Jung

Yun

et al. 2004

Journal of Reproduction and Development

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“…It has also been described that these compounds cross a blood-tissue barrier similar to that of the testis, suggesting that intratubular germ cells might be exposed [82,83]. Genistein, the principal soy isoflavone, has estrogenic activity and is widely consumed.…”

Section: Xenoestrogensmentioning

confidence: 99%

“…Genistein, the principal soy isoflavone, has estrogenic activity and is widely consumed. Doerge et al (2000) [82] measured placental transfer of genistein in rats as a possible route of developmental exposure. Pregnant Sprague-Dawley rats were administered genistein orally.…”

Section: Xenoestrogensmentioning

confidence: 99%

Occupational and Lifestyle Exposures on Male Infertility: A Mini Review

Ten¹,

Mendiola²,

Torres-Cantero³

et al. 2008

TORSJ

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Human semen quality may be declining due to environmental pollutants, occupational exposures or changes in lifestyle. Nonetheless, we still know little about the impact of those factors on male fertility. Some heavy metals, volatile organic compounds or xenoestrogens may compromise reproductive male function. This process could take place along the human life cycle and not only in certain stages of development. We review the main factors that affect human male fertility and their possible influence in current human reproduction.

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“…It has been shown that orally ingested GEN can cross the rat placenta and reach fetal brains from maternal serum [8]. In fact, one study detected GEN in the plasma of human umbilical cords, amniotic fluid, and in neonates, with concentrations that were similar to those in the maternal plasma [9].…”

Section: Introductionmentioning

confidence: 99%

Perinatal exposure to genistein, a soy phytoestrogen, improves spatial learning and memory but impairs passive avoidance learning and memory in offspring

Kohara

Kuwahara

Kawaguchi

et al. 2014

Physiology & Behavior

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This study investigated the effects of perinatal genistein (GEN) exposure on the central nervous system of rat offspring. Pregnant dams orally received GEN (1 or 10 mg/kg/day) or vehicle (1 ml/kg/day) from gestation day 10 to postnatal day 14. In order to assess the effects of GEN on rat offspring, we used a battery of behavioral tests, including the open-field, elevated plus-maze, MAZE and step-through passive avoidance tests. MAZE test is an appetite-motivation test, and we used this mainly for assessing spatial learning and memory. In the MAZE test, GEN groups exhibited shorter latency from start to goal than the vehicle-treated group in both sexes. On the other hand, performances in the step-through passive avoidance test were non-monotonically inhibited by GEN in both sexes, and a significant difference was observed in low dose of the GEN-treated group compared to the vehicle-treated group in female rats. Furthermore, we found that perinatal exposure to GEN did not significantly alter locomotor activity or emotionality assessed by the open-field and elevated-plus maze tests. These results suggest that perinatal exposure to GEN improved spatial learning and memory of rat offspring, but impaired their passive avoidance learning and memory.

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Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague Dawley rats

Cited by 106 publications

References 17 publications

Effects of Exposure to Genistein during Pubertal Development on the Reproductive System of Male Mice

Effects of Exposure to Genistein during Pubertal Development on the Reproductive System of Male Mice

Occupational and Lifestyle Exposures on Male Infertility: A Mini Review

Perinatal exposure to genistein, a soy phytoestrogen, improves spatial learning and memory but impairs passive avoidance learning and memory in offspring

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