Placental transfer of diphenylhydantoin in the goat

Shoeman, Don W.; Kauffman, Ralph E.; Azarnoff, Daniel L.; Boulos, Badi M.

doi:10.1016/0006-2952(72)90285-7

Cited by 22 publications

(3 citation statements)

References 8 publications

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“…The protein binding of DPH was determined by equilibrium dialysis as previously described [14], DPH was added to plasma or albumin preparations at a concen tration of 20 iig ml and dialyzed against 0.05 m phosphate buffer. The equilibrium concentrations ranged from 15 to 18 jug/rnl.…”

Section: Methodsmentioning

confidence: 99%

The Alteration of Plasma Proteins in Uremia as Reflected in their Ability to Bind Digitoxin and Diphenylhydantoin

Shoeman¹,

Azarnoff²

1972

Pharmacology

117

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Digitoxin was 86% bound to plasma from uremic patients while plasma from healthy volunteers bound 90%. The binding of diphenylhydantoin (DPH) was also depressed in uremia. We isolated albumin by curtain electrophoresis from plasma of uremic and normal individuals. Apparent association constants of albumin for DPH were: uremic 2.8 × 10⁴, normal 6.0 × 10⁴. Disc and curtain electrophoretic behavior of albumin from normal and uremic patients were similar. Isoelectric focussing revealed differences in micro-heterogeneity among albumins isolated from normal volunteers or uremic patients and commercial crystalline human serum albumin.

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Section: Methodsmentioning

confidence: 99%

The Alteration of Plasma Proteins in Uremia as Reflected in their Ability to Bind Digitoxin and Diphenylhydantoin

Shoeman¹,

Azarnoff²

1972

Pharmacology

117

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“…Given that albumin has an extremely limited capacity to cross the placenta (Boyd and others 1983), this high degree of protein binding likely limits the exposure of the fetus to closantel where maternal blood albumin levels are not diminished. This level of protein binding within maternal circulation however cannot be used as a template for binding in the fetal circulation as they often differ (Kumar and others 2000, Shoeman and others 1972) and vary throughout gestation (Kumar and others 2000). These differences are likely to influence the distribution of the drug and may result in differing localisation within fetal and maternal tissues (Mirkin 1975).…”

Section: Discussionmentioning

confidence: 99%

Closantel toxicity in a pregnant ewe at mid gestation: the pathological evaluation of the ewe and lamb nine months later

Hannon

Ellis

Guevar

et al. 2014

Vet Record Case Reports

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In February 2013, a flock of 20 pastured ewes was treated with oral closantel. Within 10 days of dosing, one 2-year-old Texel-cross ewe that was approximately three months in lamb was noticed to be spending a prolonged time in recumbency. On the 6th of March, the animal was referred to Scottish Centre for Production Animal Health and Food Safety (SCPAHFS). At admission, the ewe appeared blind, pupils were dilated with a negative menace response and pupillary light reflex bilaterally. Closantel toxicity was suspected. Following admission, this ewe was housed and was stable despite remaining blind. On April 21, a single male lamb was born. This lamb was found to have normal clinical and neurological parameters over five months of observation following birth. On postmortem examination closantel toxicity was confirmed in the ewe while following detailed gross and histological examination of all tissues of the lamb there was no indication of the toxicity suffered by its mother.

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“…While some drugs appear to bind to the same extent in mater nal and fetal plasma, such as phenytoin (32), indomethacin (34), and acetyl salicylic acid (31), others have been found to bind to a lower extent in fetal plasma, including dexamethasone (33), salicylate, (46) and meperidine (37). Much of the variation in these studies may be due to the varying gestational ages of the animals used in the studies.…”

Section: Plasma Protein Bindingmentioning

confidence: 94%

Pharmacokinetics in the Ovine Maternal-Fetal Unit

Szeto¹

1982

Annu. Rev. Pharmacol. Toxicol.

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Placental transfer of diphenylhydantoin in the goat

Cited by 22 publications

References 8 publications

The Alteration of Plasma Proteins in Uremia as Reflected in their Ability to Bind Digitoxin and Diphenylhydantoin

The Alteration of Plasma Proteins in Uremia as Reflected in their Ability to Bind Digitoxin and Diphenylhydantoin

Closantel toxicity in a pregnant ewe at mid gestation: the pathological evaluation of the ewe and lamb nine months later

Pharmacokinetics in the Ovine Maternal-Fetal Unit

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