Placental transfer and disposition of bilirubin in the pregnant monkey

Bashore, Richard A.; Smith, Florentia M.; Schenker, Steven

doi:10.1016/s0002-9378(16)34445-3

Cited by 30 publications

(10 citation statements)

References 12 publications

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“…To date, observations in animal studies and case reports of pregnant women with conjugated hyperbilirubinemia show that conjugated bilirubin does not cross the placenta from the maternal to the fetal circulation [30][31][32] . These findings contrast markedly with animal studies and observations of mothers with unconjugated hyperbilirubinemia, where the plasma concentrations of bilirubin are roughly the same between newborn and mother [18,19,[31][32][33] . This suggests a placental barrier for conjugated bilirubin.…”

mentioning

confidence: 99%

Pregnancy Outcome in Maternal Crigler-Najjar Syndrome Type II: A Case Report and Systematic Review of the Literature

Passuello

Puhl²,

Wirth³

et al. 2009

Fetal Diagn Ther

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Objective: To report a case of maternal Crigler-Najjar syndrome (CNS) type II in pregnancy, systematically review the literature for similar case reports, and to evaluate whether pregnancy is safe in patients with the disease. Data sources included the PubMed and uptodate databases. Results: A 37-year-old mother with CNS type II was treated with phenobarbital during her pregnancy and her bilirubin levels were monitored. Her newborn had mild direct hyperbilirubinemia, did not require any treatment and his postnatal follow-up showed normal growth and development as well as normal hearing. Conclusion: CNS type II is rare, and only a few pregnancies with this condition have been reported. Maternal treatment with phenobarbital lowers the unconjugated bilirubin and avoids fetal and newborn sequelae.

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confidence: 99%

Pregnancy Outcome in Maternal Crigler-Najjar Syndrome Type II: A Case Report and Systematic Review of the Literature

Passuello

Puhl²,

Wirth³

et al. 2009

Fetal Diagn Ther

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“…An eventual enhancement of the maternal bilirubin transport through placenta may be related with the etiopathogenesis of the fetal damage [21,22]. However, previous study has demonstrated in monkeys that direct bilirubin does not pass through placenta [23].…”

Section: Discussionmentioning

confidence: 98%

Estrous Cycle, Fertilility and Fetal Development in Rats with Hyperbilirubinemia

Resende¹,

Alberti²,

Petroianu³

2017

Gynecol Obstet

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Objective: Decreasing in reproductive capacity has been observed in jaundiced female rats. The animals with hyperbilirubinemia present early sexual maturation, late ovulation, reduced number of corpora lutea and precocious vaginal opening. The interaction with toxic agents leads to abnormal development of the embryos. The objective is to investigate the influence of jaundice on estrous cycle, fertility, ovaries and fetus development.Methods: 66 female rats were divided into two groups (n=33): group 1 -ligature of the biliopancreatic duct, group 2 -sham operation. These animals were paired with males. Vaginal smears were collected daily to verify pregnancy and the gestational period. The morphologic aspect of the ovaries and the corpus luteum were studied. The morphology of the fetuses were assessed. Serum bilirubins were recorded. 32 rats of the control group and 11 jaundiced rats became pregnant. Results:The 17 rats with hyperbilirubinemia that did not become pregnant presented involutive corpora lutea and modifications in their estrous cycles, remaining in pro-estrus or estrus. The pregnant rats with hyperbilirubinemia had fetuses with abnormal development. Conclusions:Fertilization occurs in jaundiced rats, but reproductive capacity is reduced, with irregular estrous cycles, involutive corpora lutea and abnormal fetal development.

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“…In monkeys there is good evidence that bilirubin in the foetal plasma remains unconjugated and that the majority crosses to the maternal circulation [Bashore et aL, 1969[Bashore et aL, L ebster et al, 1969: this is probably also true for man and the guinea pig [Bil l in g , 1965; Sc h e n k e r , D aw ber and Sc h m id , 1964], On the other hand, L ester et al [1969] have very recently published a preliminary report indicat ing that in the dog foetus near term the majority of plasma bilirubin is conjugated by the foetal liver and excreted in the bile. It is temping to suggest that the young sheep foetus resembles monkey, man and the guinea pig, whereas the older foetus resembles the dog near term.…”

Section: Discussionmentioning

confidence: 99%