Placental structure, function and drug transfer

Griffiths, S.; Campbell, Jeremy P.

doi:10.1093/bjaceaccp/mku013

Cited by 185 publications

(144 citation statements)

References 15 publications

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“…Ketamine can cross the placenta and reach the fetus showing an exceeding transfer type 2 drug dynamics, reaching higher concentrations in the fetus than in the maternal plasma (Griffiths & Campbell, ). The vast majority of clinical studies focused on the effect of ketamine on the central nervous system are oriented on its use as anesthetic agent, and not as a recreational drug.…”

Section: Discussionmentioning

confidence: 99%

Prenatal exposure to ketamine in rats: Implications on animal models of schizophrenia

Coronel-Oliveros

Pacheco-Calderón

2017

Developmental Psychobiology

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Schizophrenia is a complex neuropsychiatric disorder characterized by hallucinations, delusions, anhedonia, flat affect and cognitive impairments. The aim of this study was to propose a prenatal treatment with ketamine, a psychedelic drug that acts as a noncompetitive inhibitor of glutamate NMDA receptors, as a neurodevelopmental animal model of schizophrenia. The drug was applied (i.m. 60 mg.kgSprague-Dawley rats on gestational Day 14. Offspring behavior was studied on pubertal (4 weeks old) and adult (10 weeks old) stages. Also, hippocampal CA1-CA3 morphology was assessed in adult animals through a Nissl stain. Results showed a disinhibition and hyperactive behavior in pubertal animals exposed to ketamine, followed in adulthood with cognitive impairments, social withdrawal, anxiety, depression, and aggressive-like behaviors. In the hippocampus, a reduction of the CA3 layer thickness was observed, without changes in cell density. These results strongly suggest a robust link between prenatal pharmacologic manipulation of NMDA receptors and schizophrenia. K E Y W O R D Shippocampus, ketamine, NMDA, prenatal, schizophrenia

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Section: Discussionmentioning

confidence: 99%

Prenatal exposure to ketamine in rats: Implications on animal models of schizophrenia

Coronel-Oliveros

Pacheco-Calderón

2017

Developmental Psychobiology

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“…Pinocytosis occurs rarely except for protein-based drugs. During pinocytosis, the cell membrane invaginates and encloses the fluid or particles and then fuses again, forming a vesicle that later detaches and moves to the cell interior [110]. …”

Section: Dep Applications In Biomedical Sciencesmentioning

confidence: 99%

Dielectrophoresis for Biomedical Sciences Applications: A Review

Rahman

Ibrahim

Yafouz

2017

Sensors

170

168

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Dielectrophoresis (DEP) is a label-free, accurate, fast, low-cost diagnostic technique that uses the principles of polarization and the motion of bioparticles in applied electric fields. This technique has been proven to be beneficial in various fields, including environmental research, polymer research, biosensors, microfluidics, medicine and diagnostics. Biomedical science research is one of the major research areas that could potentially benefit from DEP technology for diverse applications. Nevertheless, many medical science research investigations have yet to benefit from the possibilities offered by DEP. This paper critically reviews the fundamentals, recent progress, current challenges, future directions and potential applications of research investigations in the medical sciences utilizing DEP technique. This review will also act as a guide and reference for medical researchers and scientists to explore and utilize the DEP technique in their research fields.

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“…Більшість досліджень виконані в гуманній медицині і вони стосуються наявності важких металів у крові матері, в репродуктивних органах і в ембріонах (Thompson & Bannigan, 2008;Вiasek et al, 2014;Bonglaisin, et al, 2017), в плодах і плаценті (Zahrzewska et al, 2002;Kippler et al, 2010;Olszowski et al, 2016), особливостей стану плацентарного бар'єра жінок під впливом екзогенних і ендогенних факторів (Griffiths & Campbell, 2015).…”

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Placental barrier permeability to Cadmium and Plumbum during cow pregnancy and at the foaling time of mares

et al. 2019

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Kalynovskyi, H., Yevtukh, L., Shnaider, V., Zakharin, V., Karpiuk, V., & Omelianenko, M. (2019). Placental barrier permeability to cadmium and plumbum during cow pregnancy and at the foaling time of mares. Scientific MessengerThe paper explores placental barrier permeability to Cadmium (Cd) and Plumbum (Pb) in cows in the dynamics of their pregnancy in the direction 'maternal blood (MB) → maternal placental compartment (MPC) → fetal placental compartment (FPC) → the umbilical cord (UC) → fetal liver (FL) → amniotic (AMF) and allantoic (ALF) fluid' and during parturition in relatively clean and contaminated with radioactive nuclides environments, with the injection of tissue medication fetoplacentat in the dry off time, and feeding with a mixture of saponite and sulphur supplementation in rations; in mares at the foaling time in the direction 'maternal blood (MBm) → the fetal placental compartment of a mare (FPCm) → the umbilical cord of a foal (UCf ) → the foal's liver (FLf) → amniotic (AMFf) and allantoic (ALFf) fluid → the allantoic membrane of a foal (ALMf)'. The age of the fetus during pregnancy was established by anatomical parameters, whereas Pb and Cd levels in blood and substrates were measured by the method of atomic absorption spectrophotometry (GOST 30170896). The MPC (caruncle) and FPC (cotyledon) were analyzed separately. Their barrier function in relation to Pb and Cd was performed at its full extent in 4-5 months of pregnancy and coincided with the highest concentration in the fetal liver. Wharton's jelly absorbed Cd in 3-4 months of gestation. With the approach of calving, Pb and Cd levels decreased in the amniotic fluid and increased in the allantoic fluid. Under the influence of fetoplacentat in MPC and FPC Cd accumulated better in AMF and ALF, whereas its levels were lower in the cortical mucus of the cervix. Pb deposited in equal concentrations in MPC of all the cows (0.46 ± 0.18 μg/kg in the contaminated environment and 0.47 ± 0.17 μg/kg in the relatively clean environment). In the relatively clean environment its levels in ALF were lower in 8 times (0.62 ± 0.16 μg/kg and 0.08 ± 0.04 μg/kg) and 26 times lower in AMF (0.52 ± 0.07 μg/kg and 0.02 ± 0.002 μg/kg), whereas Pb concentration in the cortical mucus of the cervix was 17 times lower (0.06 ± 0.03μg/kg) than that in the contaminated environment, (1.01 ± 0.28 μg/kg). Pb transited from MPC (0.46 ± 0.18 μg/kg) to FPC (0.51 ± 0.19 μg/kg), deposited in the internal environment of the uterus wherefrom it was absorbed by the cortical mucus of the cervix (1.01 ± 0.28 μg/kg). While transiting through the fetal body Pb accumulated in amniotic (0.52 ± 0.07 μg/kg) and allantoic fluid (0.62 ± 0.16 μg/kg). Mineral supplement in rations led to a weakened barrier function of MPC (0.23 ± 0.14 μg/kg), a two-fold increase of Pb in FPC (0.47 ± 0.11 μg/kg), whereas in the allantoic (0.16 ± 0.05 μg/kg) and amniotic (0.38 ± 0.10 μg/kg) fluid Pb concentration was lower when compared to the control group (0.62 ± 0.16 μg/kg; Р < 0.05 і 0.52 ± 0.07 μg/kg; Р < 0.0...

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Placental structure, function and drug transfer

Cited by 185 publications

References 15 publications

Prenatal exposure to ketamine in rats: Implications on animal models of schizophrenia

Prenatal exposure to ketamine in rats: Implications on animal models of schizophrenia

Dielectrophoresis for Biomedical Sciences Applications: A Review

Placental barrier permeability to Cadmium and Plumbum during cow pregnancy and at the foaling time of mares

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