Placental secreted factors: Their role in the regulation of anti-CII antibodies and amelioration of collagen induced arthritis in rats

Cortés, Micaela; Canellada, Andrea; Miranda, Silvia; Dokmetjian, José Christian; Gentile, Teresa

doi:10.1016/j.imlet.2008.04.001

Cited by 6 publications

(13 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the in vivo studies (10/12 studies) obtained CM from bone marrow MSCs of humans, rats or mice (9/10 studies) (Ando et al, ; Hwang et al, ; Ishikawa et al, ; Inukai et al, ; Katagiri et al, ; Kawai et al, ; Osugi et al, ; Ogata et al, ; Tsuchiya et al, ) (Table ), from UCB (1/10 studies) (An et al, ) or SHED (1/10 studies) (Ishikawa et al, ) (Table ). The other in vivo studies used CM from placenta, J774 macrophages or fibroblasts (FBs) (Ando et al, ; Cortés, Canellada, Miranda, Dokmetjian, & Gentile, ; Malerba et al, ) (Table , Figure ).…”

Section: Resultsmentioning

confidence: 99%

The use of cell conditioned medium for musculoskeletal tissue regeneration

Veronesi

Borsari

Sartori

et al. 2017

Journal Cellular Physiology

View full text Add to dashboard Cite

Tissue regenerative medicine combines the use of cells, scaffolds, and molecules to repair damaged tissues. Different cell types are employed for musculoskeletal diseases, both differentiated and mesenchymal stromal cells (MSCs). In recent years, the hypothesis that cell-based therapy is guided principally by cell-secreted factors has become increasingly popular. The aim of the present literature review was to evaluate preclinical and clinical studies that used conditioned medium (CM), rich in cell-factors, for musculoskeletal regeneration. Thirty-one were in vitro, 12 in vivo studies, 1 was a clinical study, and 2 regarded extracellular vesicles. Both differentiated cells and MSCs produce CM that induces reduction in inflammation and increases synthetic activity. MSC recruitment and differentiation, endothelial cell recruitment and angiogenesis have also been observed. In vivo studies were performed with CM in bone and periodontal defects, arthritis and muscle dystrophy pathologies. The only clinical study was performed with CM from MSCs in patients needing alveolar bone regeneration, showing bone formation and no systemic or local complications. Platelet derived growth factor receptor β, C3a, vascular endothelial growth factor, monocyte chemoattractant protein-1 and -3, interleukin 3 and 6, insulin-like growth factor-I were identified as responsible of cell migration, proliferation, osteogenic differentiation, and angiogenesis. The use of CM could represent a new regenerative treatment in several musculoskeletal pathologies because it overcomes problems associated with the use of cells and avoids the use of exogenous GFs or gene delivery systems. However, some issues remain to be clarified.

show abstract

Section: Resultsmentioning

confidence: 99%

The use of cell conditioned medium for musculoskeletal tissue regeneration

Veronesi

Borsari

Sartori

et al. 2017

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

“…Nevertheless, our findings are in line with other studies that looked at the effect of placenta on inflammation. Cortes et al reported that supernatants of placental cultures diminish disease severity in a rat model of collagen-induced arthritis [17] while Jash et al found that porcine placental extract decreased the severity of a contact hypersensitivity reaction [31]. Interestingly, both of these groups noted that TNF-α, along with several other cytokines, was decreased in the placenta treated group.…”

Section: Discussionmentioning

confidence: 99%

“…The demonstration that TNF-α is critically involved in the pathogenesis of some autoimmune diseases like arthritis [17] and Crohn-like ileitis [32] has paved the way for the development of TNF-α blocking therapies that have revolutionized the management of patients affected by rheumatoid arthritis [33, 34], Crohn disease [35], or psoriasis [36]. The same anti-TNF-α therapy, however, has proved deleterious in other autoimmune diseases like multiple sclerosis where it exacerbates [37, 38] or even induces demyelination-dependent manifestations [39, 40].…”

Section: Discussionmentioning

confidence: 99%

“…In systemic lupus erythematosus, repeated pregnancies improved skin lesions and decreased plasma IFN-γ levels but exacerbated nephritis [15]. In arthritis, pregnancy improved a proteoglycan-induced model of the disease [16], and placental culture supernatants ameliorated a collagen-induced model possibly via inhibition of TNF-α and IFN-γ [17]. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Placenta suppresses experimental autoimmune hypophysitis through soluble TNF receptor 1

Landek-Salgado

Rose

Caturegli

2012

Journal of Autoimmunity

View full text Add to dashboard Cite

Pregnancy modulates autoimmune diseases through diverse and still incompletely defined mechanisms, in part operating at the decidua-placenta interface. To assess the immunological contribution of placenta, we administered mouse placental proteins to a mouse model of autoimmune hypophysitis, a disease known to be strongly associated with pregnancy. Emulsified placental proteins suppressed both the cellular and humoral aspects of hypophysitis. Suppression was specific to self antigens and not seen when two foreign antigens, tetanus toxoid or tuberculin purified protein derivative, were used. Proteomic analysis revealed high levels of soluble TNF receptor 1 in placenta, suggesting that blockade of the TNF-α pathway was a mechanism of disease suppression. Placentas derived from mice deficient in TNF receptor 1 lost the ability to suppress hypophysitis. Notably, hypophysitis suppression was seen only when the TNF-α pathway was blocked locally, at the site of immunization, and not systemically. These findings provide evidence that placenta contributes to the immune tolerance of pregnancy by locally inhibiting the TNF-α pathway.

show abstract

“…Immunoglobulin preparation from the sera of arthritic mice has been shown to induce disease in other mice of the same strain [25] .To evaluate the role of CCK-8 treatment in the amelioration of CIA, we examined the levels of CII -speciWc Ab and its subtypes. CII-speciWc IgG level, particularly that of IgG2a, in sera from CCK-8 treated mice was signiWcantly lower a * than those from the control mice, whereas the levels of IgG1 were not diVerent between the two groups (Fig.…”

Section: Cck-8 Regulated Anti-cii Antibody and Its Subtypes In Ciamentioning

confidence: 99%

Cholecystokinin octapeptide exerts its therapeutic effects on collagen-induced arthritis by suppressing both inflammatory and Th17 responses

Cong

Shan

et al. 2010

Rheumatol Int

View full text Add to dashboard Cite

The purpose of this study was to evaluate the potential therapeutic effect of cholecystokinin octapeptide (CCK-8) on collagen-induced arthritis (CIA), an accepted murine experimental disease model with diverse histopathological features similar to human rheumatoid arthritis (RA). CIA was induced in DBA/1J mice by immunization with chicken collagen type II (CII). CCK-8 at different doses was intraperitoneally administered daily for 1 week. Mice treated with CCK-8 at doses of 5 and 10 nmol but not 1 nmol displayed much delayed onset of CIA and significantly lower incidence and decreased severity of arthritis. CCK-8 treatment significantly reduced the production of cytokines (IL-17, IL-23, IL-6 and TNF-α) and chemokines monocyte chemoattractant protein 1 in the joints of arthritic mice or in synovial cell culture supernatant, and increased the levels of IFN-γ and TGF-β. T cells from CCK-8 treated mice proliferated much less, produced low level of IL-17 and high levels of IFN-γ and TGF-β. Moreover, CCK-8 treated mice showed lower levels of CII-specific IgG, particularly that of IgG2a, in sera than those from control mice. These results indicate that CCK-8 is effective in suppressing both inflammatory and Th17 responses in CIA. CCK-8 may represent a new therapeutic modality for rheumatoid arthritis.

show abstract

Placental secreted factors: Their role in the regulation of anti-CII antibodies and amelioration of collagen induced arthritis in rats

Cited by 6 publications

References 54 publications

The use of cell conditioned medium for musculoskeletal tissue regeneration

The use of cell conditioned medium for musculoskeletal tissue regeneration

Placenta suppresses experimental autoimmune hypophysitis through soluble TNF receptor 1

Cholecystokinin octapeptide exerts its therapeutic effects on collagen-induced arthritis by suppressing both inflammatory and Th17 responses

Contact Info

Product

Resources

About