2019
DOI: 10.1016/j.ejogrb.2018.12.039
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Placental morphology, apoptosis, angiogenesis and epithelial mechanisms in early-onset preeclampsia

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Cited by 43 publications
(27 citation statements)
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“…Placental blood supply is associated with abnormal expression of VEGF and PIGF, and thus of Flt-1 [39]. The gene and protein expression of these markers is abnormal in placental vascular diseases [40]. We also saw this abnormal profile of Flt-1 and PIGF in placental villi, both of which were upregulated in the extracellular matrix.…”
Section: Discussionmentioning
confidence: 63%
See 1 more Smart Citation
“…Placental blood supply is associated with abnormal expression of VEGF and PIGF, and thus of Flt-1 [39]. The gene and protein expression of these markers is abnormal in placental vascular diseases [40]. We also saw this abnormal profile of Flt-1 and PIGF in placental villi, both of which were upregulated in the extracellular matrix.…”
Section: Discussionmentioning
confidence: 63%
“…Sixty-two were clinically diagnosed with CVD, with a median age of 33 years (22-40) and median gestational age (weeks) of 40.5 (39-41.5). In parallel, 52 controls with no history of CVD (HC) were studied, with a median age of 34 years (27-41) and median gestational age (weeks) of 41 (39)(40)(41)(42). This study was conducted according to the basic ethical principles of autonomy, beneficence, non-maleficence, and distributive justice.…”
Section: Study Populationmentioning
confidence: 99%
“…Many studies have confirmed that the normal development of the placenta depends on the precise temporal and spatial regulation by apoptosis and its normal function rests on the balance between the proliferation, differentiation, and apoptosis of trophoblasts. Abnormal placental function is closely related to the abnormal apoptosis of the placenta (Shahid, Khalid, & Fatima, ; Travaglino et al, ).…”
Section: Introductionmentioning
confidence: 99%
“…In developed countries, postponement of childbearing increases the risks associated with PE, as delayed childbearing correlates with obesity and vascular diseases [ 2 ]. PE is also characterized by placental dysfunction, which is closely associated with the abnormal invasion and remodeling of maternal uterine arteries by trophoblasts [ 3 ]. Determining the molecular mechanisms associated with inadequate trophoblastic invasion and growth may help in understanding the pathogenesis of PE [ 4 ].…”
Section: Introductionmentioning
confidence: 99%