Placental morphology, apoptosis, angiogenesis and epithelial mechanisms in early-onset preeclampsia

Travaglino, Antonio; Raffone, Antonio; Saccone, Gabriele; Migliorini, Sonia; Maruotti, Giuseppe Maria; Esposito, G.; Mollo, Antonio; Martinelli, Pasquale; Zullo, Fulvio; D’Armiento, Maria

doi:10.1016/j.ejogrb.2018.12.039

Cited by 41 publications

(25 citation statements)

References 30 publications

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“…Placental blood supply is associated with abnormal expression of VEGF and PIGF, and thus of Flt-1 [39]. The gene and protein expression of these markers is abnormal in placental vascular diseases [40]. We also saw this abnormal profile of Flt-1 and PIGF in placental villi, both of which were upregulated in the extracellular matrix.…”

Section: Discussionmentioning

confidence: 63%

“…Sixty-two were clinically diagnosed with CVD, with a median age of 33 years (22-40) and median gestational age (weeks) of 40.5 (39-41.5). In parallel, 52 controls with no history of CVD (HC) were studied, with a median age of 34 years (27-41) and median gestational age (weeks) of 41 (39)(40)(41)(42). This study was conducted according to the basic ethical principles of autonomy, beneficence, non-maleficence, and distributive justice.…”

Section: Study Populationmentioning

confidence: 99%

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Increased Angiogenesis and Lymphangiogenesis in the Placental Villi of Women with Chronic Venous Disease during Pregnancy

Ortega

Sáez

Fraile-Martínez

et al. 2020

IJMS

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Pregnancy is a period in a woman’s life associated with an increased risk of developing lower extremity chronic venous disease (CVD). Pregnancy-associated CVD is associated with changes in placental villi. We investigated angiogenesis and lymphangiogenesis in the placental villi of women with CVD during pregnancy compared with healthy controls with no history of CVD (HC). An observational, analytical, and prospective cohort study was conducted on 114 women in their third trimester of pregnancy (32 weeks). Sixty-two participants were clinically diagnosed with CVD. In parallel, 52 controls with no history of CVD (HC) were studied. Gene and protein expression of CD31, podoplanin (D2-40), Flt-1, and placental growth factor (PIGF) was analysed by real-time polymerase chain reaction (RT-qPCR) and immunohistochemistry. CD31 and D2-40 gene expression was significantly greater in the placental villi of women with CVD, as were the numbers of vessels positive for CD31 and D2-40. Significantly higher gene and protein expression of Flt-1 and PIGF was observed in the placental villi of women with CVD. Histological analysis showed more placental villi with periodic acid of Schiff (PAS)-positive material in women with CVD. Our results show a connection between pregnancy-associated CVD and leading to higher proangiogenic and lymphangiogenic activity in placental villi.

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Section: Discussionmentioning

confidence: 63%

Section: Study Populationmentioning

confidence: 99%

Increased Angiogenesis and Lymphangiogenesis in the Placental Villi of Women with Chronic Venous Disease during Pregnancy

Ortega

Sáez

Fraile-Martínez

et al. 2020

IJMS

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“…Many studies have confirmed that the normal development of the placenta depends on the precise temporal and spatial regulation by apoptosis and its normal function rests on the balance between the proliferation, differentiation, and apoptosis of trophoblasts. Abnormal placental function is closely related to the abnormal apoptosis of the placenta (Shahid, Khalid, & Fatima, ; Travaglino et al, ).…”

Section: Introductionmentioning

confidence: 99%

Gastrodin improves preeclampsia‐induced cell apoptosis by regulation of TLR4/NF‐κB in rats

Mei

Huang

Qian

et al. 2020

Food Science & Nutrition

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To explain gastrodin improved cell apoptosis induced by preeclampsia in vivo and in vitro study. The PE and normal rats were injected with normal saline (Model), low‐dose gastrodin (Gas‐L), medium‐dose gastrodin (Gas‐M), and high‐dose gastrodin (Gas‐H) groups at 50, 100, or 200 mg/kg per day. The rat blood pressure and 24‐hr urine protein level were measured at pregnant days 10, 16, and 20. Evaluating pathology by H&E staining, the cell apoptosis by TUNEL, and MyD88 and NF‐κB (p65) proteins by IHC assay using H/R to simulate PE cell model. Measuring cell proliferation, apoptosis, and MyD88 and NF‐κB (p65) protein expression by MTT, flow cytometry, and WB assay. The SBP, DBP, and 24‐hr urine protein levels were significantly different in PE rats (p < .05). The SBP, DBP, and 24‐hr urine protein levels were significantly improved (p < .05) in vivo and in vitro. The positive apoptosis cells and apoptosis rate were significantly increased with MyD88 and NF‐κB (p65) proteins upregulation (p < .05). The positive apoptosis cells and apoptosis rate were significantly decreased with MyD88 and NF‐κB (p65) proteins depressing in gastrodin‐treated groups with dose‐dependent (p < .05). Gastrodin improves PE‐induced cell apoptosis and pathology changed via MyD88/NF‐κB pathway in vitro and in vivo study.

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“…In developed countries, postponement of childbearing increases the risks associated with PE, as delayed childbearing correlates with obesity and vascular diseases [ 2 ]. PE is also characterized by placental dysfunction, which is closely associated with the abnormal invasion and remodeling of maternal uterine arteries by trophoblasts [ 3 ]. Determining the molecular mechanisms associated with inadequate trophoblastic invasion and growth may help in understanding the pathogenesis of PE [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNA Nuclear-Enriched Abundant Transcript 1 (NEAT1) Represses Proliferation of Trophoblast Cells in Rats with Preeclampsia via the MicroRNA-373/FLT1 Axis

Teng

Song³

et al. 2020

Med Sci Monit

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Placental morphology, apoptosis, angiogenesis and epithelial mechanisms in early-onset preeclampsia

Cited by 41 publications

References 30 publications

Increased Angiogenesis and Lymphangiogenesis in the Placental Villi of Women with Chronic Venous Disease during Pregnancy

Increased Angiogenesis and Lymphangiogenesis in the Placental Villi of Women with Chronic Venous Disease during Pregnancy

Gastrodin improves preeclampsia‐induced cell apoptosis by regulation of TLR4/NF‐κB in rats

Long Non-Coding RNA Nuclear-Enriched Abundant Transcript 1 (NEAT1) Represses Proliferation of Trophoblast Cells in Rats with Preeclampsia via the MicroRNA-373/FLT1 Axis

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