Placental alpha microglobulin‐1 (AmniSure test) versus insulin‐like growth factor binding protein‐1 (Actim PROM test) for detection of premature rupture of fetal membranes

Abstract

Although AmniSure test seems to be the most accurate test to diagnose rupture of the fetal membranes with high sensitivity and specificity, in this study the sensitivity, specificity and accuracy of AmniSure test to diagnose PROM were statistically insignificant compared with the sensitivity, specificity and accuracy of Actim PROM test.

Diagnostic Modalities in Premature Rupture of Membranes

“…However, it was emphasized that there was not any significant difference between IG-FBP-1 and PAMG-1 in studies done during the period following meta-analysis. It was reported that they both were easy, rapid and simple bedside tests (21,22). Cut off values and diagnostic performances of noninvasive diagnostic tests used in PROM diagnosis by some investigators are presented in Table 1.…”

“…Recently IGFBP-1 and PAMG-1 are included in popular diagnostic methods as simple bedside tests. These tests are based on detection of relevant proteins in cervicovaginal fluids (21)(22)(23). IGFBP-1 is a major insulin-like growth factor binding protein.…”

AmnioQuick Duo+ for diagnosis of premature fetal membranes rupture

“…4,12,21 In this study, the AmnioQuick ® Duo + test had 93.6% sensitivity, 86.4% specificity, 87.3% PPV, 93.1% NPV and 90% accuracy.…”

“…4 These markers include; human chorionic gonadotropin, alpha-fetoprotein (AFP), fetal fibronectin, Placental alpha microglobulin-1 and insulin-like growth factor binding protein-1 (IGFBP-1). [7][8][9][10][11][12][13][14][15][16][17][18] Recently, a new, rapid immunoassay test AmnioQuick ® Duo + test can detect IGFBP-1/ AFP in the amnion. 4 This study designed to evaluate the accuracy of IGFBP-1/ AFP (AmnioQuick ® Duo + ) test to detect premature fetal membranes rupture compared to conventional diagnostic tests.…”

Antenatal Magnesium Sulphate (Mgso4) for Fetal NeuroProtection Prior to Preterm Labor: Mini-Review

“…b) Confirm the gestational age using; early ultrasound scan done before 20 weeks` gestation, and first day of last menstrual (LMP) [10][11][12] . c) Determine imminent labor; evidence of cervical effacement, and dilatation, ongoing contractions which are not relieved with tocolysis in women less than 30 gestational weeks`.…”