Placenta in pregnancy induced hypertension

Bandekar, Pooja; Kale, Prashant Bhimrao

doi:10.18203/2320-1770.ijrcog20180156

Cited by 3 publications

(7 citation statements)

References 5 publications

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“…Gestational age at delivery of GH groups was less than that of the control group. This result goes with that of other studies 21,22,23,24 .…”

Section: Maternal and Neonatalsupporting

confidence: 93%

“…The fibrinoid necroses were increased very high significantly in GH group when compared to normal term pregnancy. This result agrees the finding of other reaserches 21,37,24 . Fibrinoid necrosis has been considered as a hallmark of an immunological reaction within the trophoblastic tissue.…”

Section: Microscopic Observationssupporting

confidence: 93%

“…In the present study, the syncytial knots formation "and gestational age" in GH groups weredecreased. Similar findings observed by Bandekar and Kale 24 . Kristinal et al, reported that increased number of syncytial knots in placentas of mothers with GH lead to fetal growth restriction induced by hypoxia 36 .…”

Section: Microscopic Observationssupporting

confidence: 91%

“…Calcification area in this study was significantly increased in GH group. The stromal fibrosis increased high significantly in GH which corresponds with the study of other researchers found a significant increase in the stromal fibrosis 21,37,24 .…”

Section: Microscopic Observationssupporting

confidence: 89%

“…The current study showed that the mean number of hyalinization area was increased in GH cases. Similarly, the histopathological studies done by Ahmed et al, Ranga et al, and Bandekar and Kale showed significant increase in hyalinization area of hypertensive cases when compared to control cases 8, 16,24 . The mean number of calcified areas seen microscopy were more in GH groups than in normal placenta which corresponds with other studies 13 .…”

Section: Microscopic Observationssupporting

confidence: 51%

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Placentas Changes in Gestational Hypertensive Women in Duhok

Khaleel

Barwari

2019

DMJ

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Background: Placentas impact by hypertensive disorders and contribute significantly to maternal and fetal morbidity and mortality. This study was designed to investigate the gross and histological changes in the placentas of gestational hypertensive women. Patients and Methods: The samples of this cross sectional study were collected from Duhok Obstetrics and Gynecology Hospital, Duhok city, Kurdistan region, Iraq. Total 73 placentas were collected from 20-40 years old women with full-term singleton pregnancies, 25 placentas from normo-tensive mothers having no hypertension before as control group and 48 from gestational hypertension women as gestational hypertension group. The maternal and neonatal data were recorded. Immediately after delivery, the placenta was washed, dried, photographed then weighted and dimensions were measured. Morphological features were recorded. Central biopsies were taken for qualitative and quantitative histopathological examination which included: terminal villi, stromal fibrosis, fibrinoid necrosis, calcification, syncytial knots, hyalinization, medial coat proliferation of medium sized blood vessel, avascular villi, congestion, chorangiosisandvasculosyncytial membrane. Statistical analyses were done by using student t-test and chi-square test. Results: In the gestational hypertension, macroscopically, there was no statistical difference. Microscopic finding revealed a significant increase in calcification, fibrinoid necrosis, stromal fibrosesand congestion; whereas vasculosyncytial membrane and avascular villi increased insignificantly and chorangiosiswas not impacted. The gross and histological qualitative results coincided with the quantitative results. Conclusions: The placentas were significantly and adversely affected by the gestational hypertension.

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“…Gestational age at delivery of GH groups was less than that of the control group. This result goes with that of other studies 21,22,23,24 .…”

Section: Maternal and Neonatalsupporting

confidence: 93%

Section: Microscopic Observationssupporting

confidence: 93%

Section: Microscopic Observationssupporting

confidence: 91%

Section: Microscopic Observationssupporting

confidence: 89%

Section: Microscopic Observationssupporting

confidence: 51%

See 3 more Smart Citations

Placentas Changes in Gestational Hypertensive Women in Duhok

Khaleel

Barwari

2019

DMJ

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Histomorphometric Variations of the Placenta in Normal and Hypertensive Pregnancies

Talpur

Siddiqui

Khowaja

et al. 2020

J Islamabad Med Dental Coll

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Background: Pregnancy-induced hypertension is a leading cause of deleterious changes in the placenta resulting in decreased blood supply towards the placenta. The objective of the current study was to analyze the histo-morphometric variations in the placenta of women with or without known pregnancy-induced hypertension. Methods: Cross-sectional study was carried out in the Gynecology and obstetrics section of Nazeer Hussain Medical Complex, Hyderabad in collaboration with Isra University, Hyderabad from March 2019 to August 2019. A total of 100 placentae were selected and divided into two groups (control and study groups) based on the presence or absence of hypertension in pregnancy. The observations of the control group placenta were compared with the study group placentas. All placentae were observed for morphometric and histological changes. SPSS ver. 22 was used to analyze the collected data. Results: There was an increase in the mean weight of placentae among the control group as compared to the group having known hypertension cases and the difference was statistically significant (p-value <0.05). The fetoplacental weight ratio was increased among the hypertension group when compared to the statistically insignificant control group (p-value <0.05). Various gross (infarction, calcification) and histological changes (hyalinised villi, intervillous hemorrhage, decreased villous vascularity) were observed in the placentae of the hypertensive group as compared to the normal group. Conclusion: The findings of the study concluded that Preeclampsia/PIH poses harmful and serious histo-morphometric variations in the placental tissues that affect fetal outcome.

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Histology of Placenta in Normotensive and Hypertensive Cases in Khyber Pakhtunkhwa: A Comparative Study

Khan¹,

Khan

Amir

et al. 2022

PBMJ

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One of the most common pregnancy complications is Hypertension. It has a major effect on maternal and neonatal morbidities and fatalities. The placenta is an important organ for the maintenance of pregnancy and the nourishment of the fetus. Objective: To compare the morbid variations in the placenta of hypertensive and normotensive mothers. Methods: From the obstetrics and gynecology department, a hundred placentae of hypertension and normotensive females were collected. The placentae were preserved in formalin and sectioned. Blocks prepared were stained with hematoxylin and eosin. Results: The placentae from 50 normotensive mothers with 26±3.1 years (mean age) and 50 hypertensive mothers with 26± 2 years (mean age). In normotensive patients 12% Infarction was seen and 70% of severe hypertensive patients while syncytial knots were found in 70% of cases of severe hypertension, while calcification was observed in 90%. In severe hypertension, stroma fibrosis and hypervascularity increase in proportion to the degree of hypertension, with 50% and 30% cases seen in severe hypertension, respectively. Conclusions: In pregnancy hypertension causes, Stromal fibrosis syncytial knots, calcified, hypervascularity, all of which impair the uteroplacental flow of blood and lower newborn weight.

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Placenta in pregnancy induced hypertension

Cited by 3 publications

References 5 publications

Placentas Changes in Gestational Hypertensive Women in Duhok

Placentas Changes in Gestational Hypertensive Women in Duhok

Histomorphometric Variations of the Placenta in Normal and Hypertensive Pregnancies

Histology of Placenta in Normotensive and Hypertensive Cases in Khyber Pakhtunkhwa: A Comparative Study

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