Placement of Sticky Bone™ in Patients with Generalized Periodontitis Previously Treated with Coenzyme Q10

Abstract

Aim:The aim of this study was to observe the effects of coenzyme Q10 (CoQ10) in patients with localized periodontitis and place Sticky Bone™ in defects not resolved in the test or control group. Materials and methods: A total of 30 patients with periodontitis of pocket depth ≥5 mm were randomly divided into test and control groups, each comprising 25 sites, where CoQ10 was placed in the test group and methyl cellulose in the control group; all the parameters were recorded, and patients were followed up for 12 months. At the end of 12 months, patients who did not respond to subgingival placement of CoQ10 were treated surgically where Sticky Bone™ was placed and further followed up for 6 months. Results: There was significant difference between plaque index (PI), gingival index (GI), and probing pocket depth (PPD) at baseline and 1 month, and there was an increase in values of PI and PPD seen at 6 months and significant increase in values of GI, PI, and PPD seen at 12 months, and no significant difference in values was seen at 12 months and baseline. Conclusion: Coenzyme Q10 does not aid in the treatment of periodontitis. Clinical significance: Clinically, it shows that CoQ10 has no role to play in the cases of periodontitis. In such cases, without delay patients should be taken up for periodontal flap surgery after complete scaling and root planning (SRP), if the pocket does not resolve.

Evaluation of Efficacy of Coenzyme Q10 as an Adjunct to Nonsurgical Periodontal Therapy and Its Effect on Crevicular Superoxide Dismutase in Patients with Chronic Periodontitis

“…The study period for Sale et al (2014) 17 and Raut and Sethi (2016) 18 was a 4-week/1-month period and Manthena et al 19 had used CoQ10 as oral supplement. Chug and Shukla (2020) 20 corroborated the same as found by this study that CoQ10 has no beneficial effect in the treatment of periodontitis and earlier studies that supported the notion that CoQ10 had beneficial effects were studies of short duration.…”

“…10 Antioxidant therapy for treatment of periodontitis has given positive results as stated in a systemic review by Castro et al 11 CoQ10, which is also known as ubiquinone, because of its ubiquitous presence, is an antioxidant enzyme and has been studied widely for its effect in treatment of periodontal disease. [12][13][14][15][16][17][18][19][20] In the present study, an attempt had been made to evaluate the efficacy of CoQ10 in reduction of clinical parameters (GI, PI, PPD, and CAL) and its effect on SOD in GCF as an adjunct to Phase 1 periodontal therapy.…”

“… 10 Antioxidant therapy for treatment of periodontitis has given positive results as stated in a systemic review by Castro et al 11 CoQ10, which is also known as ubiquinone, because of its ubiquitous presence, is an antioxidant enzyme and has been studied widely for its effect in treatment of periodontal disease. 12 13 14 15 16 17 18 19 20 …”

“…Previous studies conducted with CoQ10 by various authors 12 13 14 15 16 17 18 19 20 did not use any biochemical parameter to assess its efficacy and the results were assessed by the clinical parameters alone.…”

Systematic Review on Protocols of Coenzyme Q10 Supplementation in Non-Surgical Periodontitis Therapy

“…The following supporting information can be downloaded at: , Table S1: Reasons for exclusions of studies in full-text screening. References [ 27 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ] are cited in the Supplementary Materials .…”