Evaluation of Efficacy of Coenzyme Q10 as an Adjunct to Nonsurgical Periodontal Therapy and Its Effect on Crevicular Superoxide Dismutase in Patients with Chronic Periodontitis

Pranam, Swagat; Palwankar, Pooja; Pandey, Ruchi; Goyal, Arvind Kumar

doi:10.1055/s-0040-1716596

Cited by 15 publications

(26 citation statements)

References 19 publications

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“…Similarly, a study by Shaheen et al [78] reported topical application of CoQ10 resulted in a significant improvement in periodontal parameters compared to scaling and root planing alone. In contrast, in a study of 16 patients with periodontitis, topical application of CoQ10 significantly increased crevicular antioxidant status (quantified as superoxide dismutase), but did not significantly affect periodontal parameters (pocket depth, plaque index, gingival index) compared to scaling and root planing alone [79].…”

Section: Periodontal Diseasementioning

confidence: 75%

Depletion and Supplementation of Coenzyme Q10 in Secondary Deficiency Disorders

Mantle¹,

Turton²,

Hargreaves³

2022

Front. Biosci. (Landmark Ed)

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Coenzyme Q10 (CoQ10) deficiency is broadly divided into two types, primary and secondary. Primary CoQ10 deficiencies are relatively rare disorders resulting from mutations in genes directly involved in the CoQ10 biosynthetic pathway, and are not a subject of this article. Secondary CoQ10 disorders are relatively common, and may occur for a variety of reasons; these include mutations in genes not directly related to the synthetic pathway, oxidative stress induced reduction of CoQ10, and the effects of pharmacological agents such as statins. CoQ10 is of key importance in cell metabolism; in addition to its role in mitochondrial oxidative phosphorylation, it is a major endogenous antioxidant, and has a role in the metabolism of sulphides, lipids and amino acids. Given its importance in cell metabolism, it is unsurprising that secondary CoQ10 deficiency has been linked with a wide range of disorders. In this article, we have reviewed evidence of secondary CoQ10 deficiency in both common and less common disorders, and highlighted those disorders in which CoQ10 supplementation has been shown to be of significant clinical benefit.

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Section: Periodontal Diseasementioning

confidence: 75%

Depletion and Supplementation of Coenzyme Q10 in Secondary Deficiency Disorders

Mantle¹,

Turton²,

Hargreaves³

2022

Front. Biosci. (Landmark Ed)

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“…[ 12 ] to test the efficacy of intrasulcular CoQ gel revealed a nonsignificant reduction for each clinical parameter on intergroup analysis between intrasulcular gel application combined with SRP and SRP alone. These results were also supported by Pranam et al .,[ 13 ] in which no statistically significant difference between clinical parameters was observed in both groups at all time intervals. They concluded that adjunctive use of CoQ 10 is not superior to SRP in the treatment of chronic periodontitis.…”

Section: Discussionmentioning

confidence: 87%

Comparative evaluation of efficacy of topical and intra-sulcular application of Co-enzyme Q10 in the non-surgical treatment of periodontal diseases

Dahiya

Malhotra

Pajnoo

et al. 2022

Journal of Indian Society of Periodontology

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Background: Periodontitis is a ubiquitous and irreversible inflammatory condition that affects the supporting structures of teeth, which could lead to tooth loss as well as contribute to systemic inflammation. During the inflammatory phase, there is a release of superoxide ions and reactive oxygen species, which causes an increase in the oxidative stress. To combat this stress, the use of certain antioxidants has been proposed, which will help in maintaining the harmonious equilibrium. Aim: The aim of the present systematic review is to investigate the efficacy of topical and intrasulcular application of coenzyme Q10 in nonsurgical treatment of periodontal disease. Materials and Methods: We conducted a systematic review on the clinical studies which compared the use of coenzyme Q10 as an adjunct to nonsurgical periodontal therapy. The studies mentioned in this review were in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and met our inclusion criteria – only randomized control trials in humans and literature published between 2000 and 2020 were included. Results: Therapies with coenzyme Q10 as an adjunct to scaling and root planing (SRP) proved to show superior improvement by reduction in the clinical parameters (plaque index, gingival index, bleeding on probing, and clinical attachment loss) when compared to SRP alone. Conclusions: Adjunctive therapy with coenzyme Q10 provides longer-lasting therapeutic effects and better results when compared with SRP alone. The possibility to use the gel as a sole agent to support standard treatment procedures in periodontitis is also suggested.

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“…The total observation period ranged from one to six months. Eight studies tested CoQ10 in an FM [ 35 , 36 , 37 , 39 , 42 , 44 , 45 , 46 ], eight in an SM study design [ 38 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ], and one did not clearly report the design [ 43 ]. Only three studies applied a placebo [ 45 , 48 , 49 ], and all other studies were controlled against SRP alone.…”

Section: Resultsmentioning

confidence: 99%

Systematic Review on Protocols of Coenzyme Q10 Supplementation in Non-Surgical Periodontitis Therapy

et al. 2023

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This systematic review focuses on the different study protocols on CoQ10 as an adjunct in non-surgical periodontitis therapy. The study protocol was developed following PRISMA guidelines and was registered in PROSPERO (CRD42021156887). A sensitive search up to January 2022 considered MEDLINE via PubMed and Web of Science, Embase, Web of Science Core Collection via Web of Science, Google Scholar, Cochrane CENTRAL, WHO (ICTRP), ClinicalTrials.gov, and grey literature. Randomized controlled (SRP with/without placebo) clinical trials (RCTs) on all types of CoQ10 administration were included. The primary outcome was probing pocket depth (PPD). Secondary outcomes were bleeding on probing, clinical attachment loss, and gingival and plaque indices. Twelve RCTs with local and five with systemic CoQ10 administration were included. The study protocols were heterogeneous. Local CoQ10 administration was performed once or several times in a period up to 15 days. Systemic CoQ10 was applied twice or three times daily for six weeks up to four months. The reporting quality was low, including missing information about CoQ10 doses. Risk of bias was high or unclear. About half of the studies reported significant group differences for PPD. Until now, no statement on the effectiveness of CoQ10 in non-surgical periodontitis therapy is possible. Further high-quality RCTs are necessary and should consider the protocol recommendations of this review.

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Evaluation of Efficacy of Coenzyme Q10 as an Adjunct to Nonsurgical Periodontal Therapy and Its Effect on Crevicular Superoxide Dismutase in Patients with Chronic Periodontitis

Cited by 15 publications

References 19 publications

Depletion and Supplementation of Coenzyme Q10 in Secondary Deficiency Disorders

Depletion and Supplementation of Coenzyme Q10 in Secondary Deficiency Disorders

Comparative evaluation of efficacy of topical and intra-sulcular application of Co-enzyme Q10 in the non-surgical treatment of periodontal diseases

Systematic Review on Protocols of Coenzyme Q10 Supplementation in Non-Surgical Periodontitis Therapy

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