Placebo controlled trial of fusidic acid gel and oxytetracycline for recurrent blepharitis and rosacea.

Abstract

(Br_J Ophthalmol 1995; 79: 42-45)

People and eyes: statistical approaches in ophthalmology

“…For example, this method was used in the study of therapies for blepharitis3 and in the investigation of the effect of smoking beedies on cataract development 8. In a further six reports the average result for the two eyes was taken.…”

“…At the other extreme are conditions such as blepharitis which almost always affect both eyes (proportion bilateral 95%3). The finding in the right eye almost perfectly predicts the finding in the left eye (fellow eye).…”

Systematic review of rosacea treatments

“…27,66,79,91 Although often mild, the ocular presentation can be both severe and debilitating. There was insufficient evidence for the efficacy of topical metronidazole.…”

Rationale for anti-inflammatory therapy in dry eye syndrome

“…A prospective, randomized, double-blind, placebo-controlled, partial crossover trial compared the effect of oxytetracycline to provide symptomatic relief of blepharitis with or without rosacea. Only 25% of the patients with blepharitis without rosacea responded to the antibiotic, whereas 50% responded when both diseases were present (92) . In another trial of 10 patients with both acne rosacea and concomitant meibomianitis, acne rosacea without concomitant ocular involvement, or seborrheic blepharitis, minocycline 50 mg daily for 2 weeks followed by 100 mg daily for a total of 3 months significantly decreased bacterial flora.…”