People and eyes: statistical approaches in ophthalmology

Murdoch, Ian; Morris, Saul S.; Cousens, Simon

doi:10.1136/bjo.82.8.971

Cited by 277 publications

(230 citation statements)

References 16 publications

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“…Our interest was in examining the relation between pulsatile ocular blood flow and the degree of diabetic retinopathy in an eye. Therefore, if the extent of pathology differed, we used each eye of a patient in an appropriate grouping and the average of two eyes if the ocular condition was the same in both eyes, providing an optimal use of the available data (Murdoch et al 1998). Excluded from the study were patients with ocular disease other than diabetes and those with a refractive error ±4 diopters.…”

Section: Methodsmentioning

confidence: 99%

Pulsatile ocular blood flow in diabetic retinopathy

Geyer

Neudorfer

Snir

et al. 1999

Acta Ophthalmologica Scandinavica

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Section: Methodsmentioning

confidence: 99%

Pulsatile ocular blood flow in diabetic retinopathy

Geyer

Neudorfer

Snir

et al. 1999

Acta Ophthalmologica Scandinavica

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“…20,21 Moreover, the inclusion of bilateral data from thirteen patients necessitated a statistical correction for potential inter-eye correlation within a subject. 22,23 To account for variable follow-up time and inter-eye correlation, an exact logistic regression analysis was performed. Using this method, a correction for bilateral cases was applied by explicitly identifying these cases and setting the case number as a conditional variable during the entire regression analysis.…”

Section: Quantitative Analysis and Statisticsmentioning

confidence: 99%

Clinical Outcome and Recurrence of Epithelial Basement Membrane Dystrophy after Phototherapeutic Keratectomy

2011

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“…VF data were treated as dependent variables and FD-OCT measurements as independent variables in all regressions. To evaluate the dependence between variables from a same patient and to provide valid statistical inferences, intraclass correlation coefficient (ICC) was performed (16) . Values of ICC lower than 0.3 were considered as a weak association (17) .…”

Section: Methodsmentioning

confidence: 99%

Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome

Moura¹,

Costa-Cunha²,

Malta³

et al. 2010

Arq. Bras. Oftalmol.

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Purpose: To correlate visual field sensitivity (VFS) loss on standard automated perimetry (SAP) and quadrantic macular thickness on optical coherence tomography (OCT) in patients with permanent temporal hemianopia from chiasmal compression. Methods: Forty eyes from 40 patients with chiasmal compression and 40 healthy eyes were submitted to standard automated perimetry and Stratus-OCT scanning. Raw data of the fast macular thickness scanning protocol were exported and macular thickness measurements were recorded and averaged for each quadrant and half of the central area. The correlation between visual field sensitivity loss and optical coherence tomography measurements was tested with Pearson's correlation coefficients and with linear regression analysis. Results: A significant association was found between each macular thickness parameter and the corresponding central VF mean sensitivity. The strongest association was observed between superonasal macular thickness and the inferotemporal mean defect measured both in decibel (R=0.47; p=0.001) and in 1/Lambert (R=0.59; p<0.0001) units. Conclusion: Stratus-OCT-measured macular thickness was topographically related with visual field sensitivity loss in patients with temporal hemianopia from chiasmal compression. Such measurements could prove clinically useful in the diagnosis and follow-up of patients with chiasmal compression. ClinicalTrial.gov identifier number: NCT0039122.Keywords: Tomography, optical coherence; Perimetry; Optic atrophy; Optic chiasm; Hemianopsia; Visual fields RESUMO Objetivo: Avaliar a correlação entre o defeito de campo visual ao exame de perimetria computadorizada e a espessura macular quadrântica ao exame de tomografia de coerência óptica (OCT) em pacientes com hemianopsia temporal permanente causada por compressão quiasmática. Métodos: Quarenta olhos de 40 pacientes com compressão quiasmática e 40 olhos de 40 indivíduos controles foram submetidos aos exames de perimetria computadorizada e tomografia de coerência óptica. Dados não processados foram exportados e as medidas de espessura macular foram calculadas para cada quadrante e metade da área macular central. A correlação entre o defeito campimétrico e as medidas de espessura macular foi avaliada por coeficiente de correlação de Pearson e por análise de regressão linear. Resultados: Associação significante foi encontrada entre os parâmetros de espessura macular e seus respectivos defeitos campimétricos. A correlação mais forte foi encontrada entre o parâmetro espessura macular nasal superior e o defeito campimétrico médio temporal inferior medido em decibel (R=0,47; p=0,001) e em 1/Lambert (R=0,59; p<0,0001). Conclusão: Medidas de espessura macular avaliada através da tomografia de coerência óptica foi topograficamente relacionada ao defeito campimétrico em pacientes com hemianopsia temporal por compressão quiasmática. Estas medidas podem provar a importância clínica no diagnóstico e seguimento dos pacientes com compressão quiasmática. ClinicalTrial.gov identifier number: NCT00391...

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People and eyes: statistical approaches in ophthalmology

Cited by 277 publications

References 16 publications

Pulsatile ocular blood flow in diabetic retinopathy

Pulsatile ocular blood flow in diabetic retinopathy

Clinical Outcome and Recurrence of Epithelial Basement Membrane Dystrophy after Phototherapeutic Keratectomy

Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome

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