Placebo and Other Interventions in Asthma

Straumann, Alex; Safroneeva, Ekaterina; Schoepfer, Alain

doi:10.1056/nejmc1109235

N Engl J Med

2011

DOI: 10.1056/nejmc1109235

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Placebo and Other Interventions in Asthma

Alex Straumann¹,

Ekaterina Safroneeva²,

Alain Schoepfer³

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Cited by 8 publications

(1 citation statement)

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“…Nowadays, this traditional technique has become very popular worldwide as a complementary medicine 3 4 . It has been widely used to reduce some symptoms or to treat diseases in clinical practice 5 6 7 . Human studies have found a physiological basis for acupuncture needling that involves both central and peripheral networks 8 .…”

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Deciphering the biological effects of acupuncture treatment modulating multiple metabolism pathways

Zhang

Sun

et al. 2016

Sci Rep

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Acupuncture is an alternative therapy that is widely used to treat various diseases. However, detailed biological interpretation of the acupuncture stimulations is limited. We here used metabolomics and proteomics technology, thereby identifying the serum small molecular metabolites into the effect and mechanism pathways of standardized acupuncture treatments at ‘Zusanli’ acupoint which was the most often used acupoint in previous reports. Comprehensive overview of serum metabolic profiles during acupuncture stimulation was investigated. Thirty-four differential metabolites were identified in serum metabolome and associated with ten metabolism pathways. Importantly, we have found that high impact glycerophospholipid metabolism, fatty acid metabolism, ether lipid metabolism were acutely perturbed by acupuncture stimulation. As such, these alterations may be useful to clarify the biological mechanism of acupuncture stimulation. A series of differentially expressed proteins were identified and such effects of acupuncture stimulation were found to play a role in transport, enzymatic activity, signaling pathway or receptor interaction. Pathway analysis further revealed that most of these proteins were found to play a pivotal role in the regulation of multiple metabolism pathways. It demonstrated that the metabolomics coupled with proteomics as a powerful approach for potential applications in understanding the biological effects of acupuncture stimulation.

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Deciphering the biological effects of acupuncture treatment modulating multiple metabolism pathways

Zhang

Sun

et al. 2016

Sci Rep

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Pharmacologic Treatment of Eosinophilic Esophagitis

Straumann¹,

Safroneeva²

2015

Curr Treat Options Allergy

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Eosinophilic esophagitis I Natural history I Esophageal remodeling I Food impaction I Indications for treatment I Corticosteroids I Immunosuppressants I Biologic therapy I Unmet needs Opinion statement Eosinophilic esophagitis (EoE) is an immune-mediated, chronic inflammatory disease of the esophagus. If left untreated, eosinophilic inflammation induces esophageal remodeling with fibrosis and stricture formation, and patients are permanently at risk of experiencing food impactions. Therefore, it is widely accepted that active EoE should be treated. An ideal EoE therapy should achieve two therapeutic goals: first, to resolve symptoms and, second, to control inflammation. Avoidance of food allergens by the means of food elimination diets as well as anti-inflammatory drugs has the ability to achieve both of these goals. Among the pharmacologic options, only corticosteroids have documented efficacy, whereas alternatives have shown rather disappointing results or are still under evaluation. Swallowed topical corticosteroids (TCS) are at least as efficient as systemically administered corticosteroids (SCS) and have fewer side effects. As such, TCS are widely used as a first-line drug in the treatment of EoE, even though this compound is not approved for this indication by regulatory authorities. Unfortunately, the therapeutic goals cannot be achieved in approximately 30 % of EoE patients, despite appropriate treatment with corticosteroids. For this Bdifficult-to-treat^patient category, therapeutic alternatives are urgently needed. Key points 1. Clinically and histologically active eosinophilic esophagitis must be treated, even when patients effectively cope with their symptoms. 2. Swallowed topical corticosteroids have proven efficacy, a good safety profile and are currently used as a first-line pharmacologic treatment of eosinophilic esophagitis. 3. Eosinophilic esophagitis is a chronic disease; as such, a long-term follow-up and therapeutic strategy is needed.

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Acupuncture targeting and regulating multiple signaling pathways related to Zusanli acupoint using iTRAQ-based quantitative proteomic analysis

Sun

Zhang

et al. 2014

Acupuncture and Related Therapies

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Placebo and Other Interventions in Asthma

Cited by 8 publications

References 11 publications

Deciphering the biological effects of acupuncture treatment modulating multiple metabolism pathways

Deciphering the biological effects of acupuncture treatment modulating multiple metabolism pathways

Pharmacologic Treatment of Eosinophilic Esophagitis

Acupuncture targeting and regulating multiple signaling pathways related to Zusanli acupoint using iTRAQ-based quantitative proteomic analysis

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