Acupuncture targeting and regulating multiple signaling pathways related to Zusanli acupoint using iTRAQ-based quantitative proteomic analysis

Sun, Hui; Zhang, Aihua; Ge, Yan; Zhang, Yingzhi; Meng, Xiangcai; Liu, Li; Xie, Ning; Cheng, Weiping; Wang, Xijun

doi:10.1016/j.arthe.2014.03.002

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…The overall effects of acupuncture include non-specific physiological effects and pathology-specific effects. Several studies have shown that acupuncture altered protein expression in humans and rats in healthy states produces [ 37 , 38 ]. It was suggested that the non-specific physiological changes of acupuncture were achieved through multiple biological pathways involving DEPs.…”

Section: Application Of Proteomics In Acupuncture Researchmentioning

confidence: 99%

Proteomics and its application in the research of acupuncture: An updated review

Zhong,

Sun,

et al. 2024

Heliyon

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Section: Application Of Proteomics In Acupuncture Researchmentioning

confidence: 99%

Proteomics and its application in the research of acupuncture: An updated review

Zhong,

Sun,

et al. 2024

Heliyon

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“…iTRAQ-based quantitative proteomics was performed to identify key proteins in the blood sample for acupuncture at “Zusanli” acupoint (ST-36) in patients, and a total of seven related proteins were identified. These proteins, aldolase A protein, hCG2008184, ATP synthase, ATP5A1 protein, and hexokinase type 1, were involved in the regulation of multiple metabolism pathways, which may help elucidate the action mechanism of ST-36 acupuncture [ 78 ].…”

Section: Proteomic Studies Of Clinical Tcm Treatments Using Chinesmentioning

confidence: 99%

Recent Advance in Applications of Proteomics Technologies on Traditional Chinese Medicine Research

Zhu

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Proteomics technology, a major component of system biology, has gained comprehensive attention in the area of medical diagnosis, drug development, and mechanism research. On the holistic and systemic theory, proteomics has a convergence with traditional Chinese medicine (TCM). In this review, we discussed the applications of proteomic technologies in diseases-TCM syndrome combination researches. We also introduced the proteomic studies on the in vivo and in vitro effects and underlying mechanisms of TCM treatments using Chinese herbal medicine (CHM), Chinese herbal formula (CHF), and acupuncture. Furthermore, the combined studies of proteomics with other “-omics” technologies in TCM were also discussed. In summary, this report presents an overview of the recent advances in the application of proteomic technologies in TCM studies and sheds a light on the future global and further research on TCM.

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“…The series of proteins comprising the electron transport chain in the inner mitochondrial matrix. The target binding site for Antimycin-A is the Qi subunit within cytochrome b (complex III).Image by M. Martinez as modified from[42].…”

mentioning

confidence: 99%

Amino Acid Variation at the Mitochondrial Binding Site of Antimycin A is Proposed to Reflect Sensitivity and Toxicity Differences among Fish Species

Baudoin

Brown

Calfee

et al. 2023

Fishes

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To better understand differential sensitivities among fish species to the piscicidal compound Antimycin-A (ANT-A), we hypothesized that variations in amino acids at the ANT-A binding site may reflect toxicity differences. Protein sequences for six motifs comprising the ANT-A binding site were obtained and compared for invasive carp species (N = 515) and seven non-target species (N = 277); a consensus was delineated from each species. The carp species, Common Carp (Cyprinus carpio), Silver Carp (Hypophthalmichthys molitrix), Bighead Carp (Hypophthalmichthys nobilis), Grass Carp (Ctenopharyngodon idella), and Black Carp (Mylopharyngodon piceus), showed the same amino acids at the site; thus, it was termed the carp consensus motif sequence (CCM). Channel Catfish (Ictalurus punctatus) showed the most amino acid polymorphisms, with three motifs 96–100% different from CCM. Within a species, Bluegill (Lepomis macrochirus) and Fathead Minnow (Pimephales promelas) variation per motif was most dissimilar (46.7% and 21.6%, respectively). Organismal mortality data from the literature indicated Yellow Perch (Perca flavescens), Walleye (Sander vitreus), and American Gizzard Shad (Dorosoma cepedianum) to be most sensitive to the piscicide, Catfish least sensitive, and all others intermediate. The protein sequence variations of the binding site appeared to be in accord with organismal sensitivity categories when they differed from the CCM; the motifs in Gizzard Shad and Walleye were the same as in CCM. The physical/chemical nature of ANT-A is important to consider in organismal response comparisons. This cellular approach of studying ANT-A binding at its target enzyme is a non-destructive way to predict piscicidal efficacy of ANT-A against fishes of interest, informs management decisions in control efforts for invasives, and can be used to forecast effects on sympatric species.

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Acupuncture targeting and regulating multiple signaling pathways related to Zusanli acupoint using iTRAQ-based quantitative proteomic analysis

Cited by 4 publications

References 21 publications

Proteomics and its application in the research of acupuncture: An updated review

Proteomics and its application in the research of acupuncture: An updated review

Recent Advance in Applications of Proteomics Technologies on Traditional Chinese Medicine Research

Amino Acid Variation at the Mitochondrial Binding Site of Antimycin A is Proposed to Reflect Sensitivity and Toxicity Differences among Fish Species

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