Place of low-dose total body irradiation in the treatment of localized follicular non-Hodgkin's lymphoma: Results of a pilot study

A Systematic Overview of Radiation Therapy Effects in Non-Hodgkin's Lymphoma

“…Twenty-four patients achieved complete remission after TBI, and after a median follow-up of 53 months, 19 patients remained alive and disease free (30). These results initiated an EORTC (European Organization for Research and Treatment of Cancer) trial comparing radiotherapy to involved fields with TBI plus involved fields in indolent lymphomas in stage I Á/II.…”

Nodal Follicular Lymphoma

“…The EORTC initiated a randomized phase III trial with low-dose total-body irradiation (TBI, 1,5 Gy) and IFI (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) Gy) versus IFI (26-40 Gy) alone based on promising phase II data [44]. This study aims to confirm the postulated direct or indirect influence of low-dose TBI on apoptosis and bcl-2 regulation potentially leading to enhanced OS.…”

Research of the adaptive response induced by low-dose radiation: where have we been and where should we go?

“…They live without any acute nonlymphoblastic leukemia or myelodysplasic syndrome with a median follow-up of 88 months, 42 and 56.2 months. 43 Although they did not discuss any issues related to LDR-induced AR or hormesis for the mechanism of this bene®cial effect, this may suggest a role of LDR hormesis in immunity and AR in the hematopoietic tolerance in this ef®cient treatment. LDR-induced AR showed a wide cross-resistance of oxidative damage from other clastogens as shown in Figure 1.…”