Place de la distension pulmonaire dans l’exploration des gros fumeurs de cigarettes

Saad, Helmi Ben; Amor, Leïla Ben; Mdalla, S. Ben; Ghannouchi, I.; Essghair, M. Ben; Sfaxi, R.; Garrouche, A.; Rouatbi, N.; Rouatbi, Sonia

doi:10.1016/j.rmr.2013.05.009

Cited by 20 publications

(9 citation statements)

References 53 publications

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“…Second, the present study COPD sample was also representative of COPD population where obesity prevalence is around 18% (48). In a recent local study (42), it was found that 13% of the 366 COPD smokers have obesity. Third, the two groups of Non-COPD and COPD contain statistically similar percentages of obese smokers.…”

Section: Discussionmentioning

confidence: 99%

“…This index selection is the most widely used among the indices of forced expiration to study the variations of lung obstruction after bronchodilator use (40). TLC and RV are two volumes often used in practice to evaluate lung hyperinflation, a pattern frequently seen in smokers (42). Lung hyperinflation, a major functional consequence of COPD, is well correlated with dyspnea (45).…”

Section: Discussionmentioning

confidence: 99%

“…Lung hyperinflation was defined as an abnormal increase in RV higher than the upper limit of normal (42). COPD diagnosis was retained when the post-bronchodilator FEV 1 /FVC ratio was lower than 0.70 (3, 4).…”

Section: Populations and Methodsmentioning

confidence: 99%

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Oxidative stress and lung function profiles of male smokers free from COPD compared to those with COPD: a case-control study

Moussa

Sfaxi

Tabka

et al. 2014

Libyan Journal of Medicine

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BackgroundThe mechanisms of smoking tobacco leading to chronic obstructive pulmonary disease (COPD) are beginning to be understood. However, conclusions about the role of blood or lung oxidative stress markers were disparate.AimsTo investigate the oxidative stress in blood or lung associated with tobacco smoke and to evaluate its effect on pulmonary function data and its relation with physical activity.MethodsIt is a case-control study. Fifty-four male-smokers of more than five pack-years (PY) and aged 40–60 years were included (29 Non-COPD, 16 COPD). Physical activity score was determined. Blood sample levels of malondialdehyde (MDA), protein-cys-SH (PSH), and Glutathione (GSH) were measured. Fractional exhaled nitric oxide (FeNO) and plethysmographic measurements were performed. Correlation coefficients (r) evaluated the association between oxidative stress markers and independent variables (plethysmographic data and physical activity score).ResultsNon-COPD (48±6 years) and COPD (49±5 years) groups had similar tobacco consumption patterns, that is, 27±14 PY versus 30±19 PY, respectively. Compared to the Non-COPD group, the COPD group had significantly lower levels of GSH and PSH, that is, mean±SE were 40±6 versus 25±5 µg/mL and 54±10 versus 26±5 µg/g of hemoglobin, respectively. However, MDA level and FeNO values were similar. In the COPD group, none of the oxidative stress markers was significantly correlated with plethysmographic data or physical activity score. In the Non-COPD group, GSH was significantly correlated with physical activity score (r = 0.47) and PSH was significantly correlated with total lung capacity (TLC) (r=−0.50), residual volume (r = 0.41), and physical activity score (r = 0.62). FeNO was significantly correlated with TLC of the COPD group (r=−0.48).ConclusionCompared to the Non-COPD group, the COPD group had a marked decrease in blood antioxidant markers (GSH and PSH) but similar blood oxidant (MDA) or lung (FeNO) burden.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Oxidative stress and lung function profiles of male smokers free from COPD compared to those with COPD: a case-control study

Moussa

Sfaxi

Tabka

et al. 2014

Libyan Journal of Medicine

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“…To our knowledge, the present study is the first that measured lung volumes, which are important data for the diagnosis of restrictive defect and lung hyperinflation [27, 47]. …”

Section: Discussionmentioning

confidence: 99%

Fraction of Exhaled Nitric Oxide (Fe_NO) Norms in Healthy Tunisian Adults

Rouatbi

Chouchène

Sfaxi

et al. 2014

BioMed Research International

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Aims. To establish FeNO norms for healthy Tunisian adults aged 18–60 years and to prospectively assess their reliability. Methods. This was a cross-sectional analytical study. A convenience sample of healthy Tunisian adults was recruited. Subjects responded to a medical questionnaire, and then FeNO levels were measured by an online method (Medisoft, Sorinnes (Dinant), Belgium). Clinical, anthropometric, and plethysmographic data were collected. All analyses were performed on natural logarithm values of FeNO. Results. 257 adults (145 males) were retained. The proposed reference equation to predict FeNO value is lnFeNO (ppb) = 3.47−0.56× height (m). After the predicted FeNO value for a given adult was computed, the upper limit of normal could be obtained by adding 0.60 ppb. The mean ± SD (minimum-maximum) of FeNO (ppb) for the total sample was 13.54 ± 4.87 (5.00–26.00). For Tunisian and Arab adults of any age and height, any FeNO value greater than 26.00 ppb may be considered abnormal. Finally, in an additional group of adults prospectively assessed, we found no adult with a FeNO higher than 26.00 ppb. Conclusion. The present FeNO norms enrich the global repository of FeNO norms that the clinician can use to choose the most appropriate norms.

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“…The spirometer was calibrated daily with a 3-L syringe. The plethysmographic technique and especially the FVC maneuver, were previously described [15,[31][32][33][34][35][36]. Briefly, at least three reproducible FVC measurements were obtained [31].…”

Section: Data Collection Proceduresmentioning

confidence: 99%

The multi-ethnic global lung initiative 2012 (GLI-2012) norms reflect contemporary adult's algerian spirometry

Ketfi

Gharnaout

Bougrida

et al. 2018

Respiratory Function Technologists/Scient

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Background The validation of the multi-ethnic GLI-2012 spirometric norms has been debated in several countries. However, its applicability in Algeria has not been verified. Aim To ascertain how well the GLI-2012 norms fit contemporary adult Algerian spirometric data. Methods This was a cross-sectional study of a convenience sample of 300 healthy non-smoker adults (50% men, age range: 18-85 years) recruited from the Algiers region general population. All participants underwent a clinical examination and a plethysmography measurement. Zscores for some spirometric data [FEV 1 , FVC, FEV 1 /FVC and forced expiratory flow at 25-75% of FVC (FEF 25-75%)] were calculated. If the average Z-score deviated by "< ± 0.5" from the overall mean, the GLI-2012 norms would be considered as reflective of contemporary Algerian spirometry. Results The means±SDs of age, height, weight, FVC, FEV 1 , FEV 1 /FVC and FEF 25-75% of the participants were, respectively, 48±17 years, 1.65±0.10 m, 73±14 kg, 4.04±1.04 L, 3.18±0.82 L, 0.79±0.05 and 4.09±1.09 L/s. Almost the quarter of participants were obese. The total sample means±SDs Z-scores were 0.22±0.87 for FVC, 0.04±0.88 for FEV 1 ,-0.34±0.67 for FEV 1 /FVC and 0.93±0.79 for FEF 25-75%. For men and women, only the means±SDs of the FEF 25-75% Z-scores exceeded the threshold of "± 0.5", respectively, 1.13±0.77 and 0.73± 0.76.

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Place de la distension pulmonaire dans l’exploration des gros fumeurs de cigarettes

Cited by 20 publications

References 53 publications

Oxidative stress and lung function profiles of male smokers free from COPD compared to those with COPD: a case-control study

Oxidative stress and lung function profiles of male smokers free from COPD compared to those with COPD: a case-control study

Fraction of Exhaled Nitric Oxide (Fe_NO) Norms in Healthy Tunisian Adults

The multi-ethnic global lung initiative 2012 (GLI-2012) norms reflect contemporary adult's algerian spirometry

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Place de la distension pulmonaire dans l’exploration des gros fumeurs de cigarettes

Cited by 20 publications

References 53 publications

Oxidative stress and lung function profiles of male smokers free from COPD compared to those with COPD: a case-control study

Oxidative stress and lung function profiles of male smokers free from COPD compared to those with COPD: a case-control study

Fraction of Exhaled Nitric Oxide (FeNO) Norms in Healthy Tunisian Adults

The multi-ethnic global lung initiative 2012 (GLI-2012) norms reflect contemporary adult's algerian spirometry

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Fraction of Exhaled Nitric Oxide (Fe_NO) Norms in Healthy Tunisian Adults